A Pipeline for Volume Electron Microscopy of the Caenorhabditis elegans Nervous System

A Pipeline for Volume Electron Microscopy of the Caenorhabditis elegans Nervous System

The “connectome,” a comprehensive wiring diagram of synaptic connectivity, is achieved through volume electron microscopy (vEM) analysis of an entire nervous system and all associated non-neuronal tissues. White et al. (1986) pioneered the fully manual reconstruction of a connectome using Caenorhabd...

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Bibliographic Details
Main Authors: Ben Mulcahy, Daniel Witvliet, Douglas Holmyard, James Mitchell, Andrew D. Chisholm, Yaron Meirovitch, Aravinthan D. T. Samuel, Mei Zhen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Neural Circuits
Subjects:
C. elegans
volume electron microscopy
connectome
nervous system
high-pressure freezing
Online Access:https://www.frontiersin.org/article/10.3389/fncir.2018.00094/full

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