The Role of MicroRNAs in Recurrence and Metastasis of Head and Neck Squamous Cell Carcinoma
Head and neck squamous cell carcinoma (HNSCC) affects 650,000 people worldwide and has a dismal 50% 5-year survival rate. Recurrence and metastasis are believed the two most important factors causing this high mortality. Understanding the biological process and the underlying mechanisms of recurrenc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-03-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/11/3/395 |
| _version_ | 1797709007952019456 |
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| author | Chris X. Yang Wafik Sedhom John Song Shi-Long Lu |
| author_facet | Chris X. Yang Wafik Sedhom John Song Shi-Long Lu |
| author_sort | Chris X. Yang |
| collection | DOAJ |
| description | Head and neck squamous cell carcinoma (HNSCC) affects 650,000 people worldwide and has a dismal 50% 5-year survival rate. Recurrence and metastasis are believed the two most important factors causing this high mortality. Understanding the biological process and the underlying mechanisms of recurrence and metastasis is critical to develop novel and effective treatment, which is expected to improve patients’ survival of HNSCC. MicroRNAs are small, non-coding nucleotides that regulate gene expression at the transcriptional and post-transcriptional level. Oncogenic and tumor-suppressive microRNAs have shown to regulate nearly every step of recurrence and metastasis, ranging from migration and invasion, epithelial-mesenchymal transition (EMT), anoikis, to gain of cancer stem cell property. This review encompasses an overview of microRNAs involved in these processes. The recent advances of utilizing microRNA as biomarkers and targets for treatment, particularly on controlling recurrence and metastasis are also reviewed. |
| first_indexed | 2024-03-12T06:31:03Z |
| format | Article |
| id | doaj.art-6d03be35b76e41b5ad670fc7d0f72cb2 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T06:31:03Z |
| publishDate | 2019-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-6d03be35b76e41b5ad670fc7d0f72cb22023-09-03T01:37:57ZengMDPI AGCancers2072-66942019-03-0111339510.3390/cancers11030395cancers11030395The Role of MicroRNAs in Recurrence and Metastasis of Head and Neck Squamous Cell CarcinomaChris X. Yang0Wafik Sedhom1John Song2Shi-Long Lu3Department of Otolaryngology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADepartment of Otolaryngology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADepartment of Otolaryngology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADepartment of Otolaryngology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USAHead and neck squamous cell carcinoma (HNSCC) affects 650,000 people worldwide and has a dismal 50% 5-year survival rate. Recurrence and metastasis are believed the two most important factors causing this high mortality. Understanding the biological process and the underlying mechanisms of recurrence and metastasis is critical to develop novel and effective treatment, which is expected to improve patients’ survival of HNSCC. MicroRNAs are small, non-coding nucleotides that regulate gene expression at the transcriptional and post-transcriptional level. Oncogenic and tumor-suppressive microRNAs have shown to regulate nearly every step of recurrence and metastasis, ranging from migration and invasion, epithelial-mesenchymal transition (EMT), anoikis, to gain of cancer stem cell property. This review encompasses an overview of microRNAs involved in these processes. The recent advances of utilizing microRNA as biomarkers and targets for treatment, particularly on controlling recurrence and metastasis are also reviewed.https://www.mdpi.com/2072-6694/11/3/395HNSCCmicroRNAmetastasisEMTCSC |
| spellingShingle | Chris X. Yang Wafik Sedhom John Song Shi-Long Lu The Role of MicroRNAs in Recurrence and Metastasis of Head and Neck Squamous Cell Carcinoma Cancers HNSCC microRNA metastasis EMT CSC |
| title | The Role of MicroRNAs in Recurrence and Metastasis of Head and Neck Squamous Cell Carcinoma |
| title_full | The Role of MicroRNAs in Recurrence and Metastasis of Head and Neck Squamous Cell Carcinoma |
| title_fullStr | The Role of MicroRNAs in Recurrence and Metastasis of Head and Neck Squamous Cell Carcinoma |
| title_full_unstemmed | The Role of MicroRNAs in Recurrence and Metastasis of Head and Neck Squamous Cell Carcinoma |
| title_short | The Role of MicroRNAs in Recurrence and Metastasis of Head and Neck Squamous Cell Carcinoma |
| title_sort | role of micrornas in recurrence and metastasis of head and neck squamous cell carcinoma |
| topic | HNSCC microRNA metastasis EMT CSC |
| url | https://www.mdpi.com/2072-6694/11/3/395 |
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