Modelling of thrombus formation using smoothed particle hydrodynamics method.
In this paper a novel model, based on the smoothed particle hydrodynamics (SPH) method, is proposed to simulate thrombus formation. This describes the main phases of the coagulative cascade through the balance of four biochemical species and three type of platelets. SPH particles can switch from flu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0281424 |
| _version_ | 1811167179678154752 |
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| author | Alessandra Monteleone Alessia Viola Enrico Napoli Gaetano Burriesci |
| author_facet | Alessandra Monteleone Alessia Viola Enrico Napoli Gaetano Burriesci |
| author_sort | Alessandra Monteleone |
| collection | DOAJ |
| description | In this paper a novel model, based on the smoothed particle hydrodynamics (SPH) method, is proposed to simulate thrombus formation. This describes the main phases of the coagulative cascade through the balance of four biochemical species and three type of platelets. SPH particles can switch from fluid to solid phase when specific biochemical and physical conditions are satisfied. The interaction between blood and the forming blood clot is easily handled by an innovative monolithic FSI approach. Fluid-solid coupling is modelled by introducing elastic binds between solid particles, without requiring detention and management of the interface between the two media. The proposed model is able to realistically reproduce the thromboembolic process, as confirmed by the comparison of numerical results with experimental data available in the literature. |
| first_indexed | 2024-04-10T16:05:57Z |
| format | Article |
| id | doaj.art-6d03ebecd27a43d1af537f33668142a2 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T16:05:57Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6d03ebecd27a43d1af537f33668142a22023-02-10T05:31:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01182e028142410.1371/journal.pone.0281424Modelling of thrombus formation using smoothed particle hydrodynamics method.Alessandra MonteleoneAlessia ViolaEnrico NapoliGaetano BurriesciIn this paper a novel model, based on the smoothed particle hydrodynamics (SPH) method, is proposed to simulate thrombus formation. This describes the main phases of the coagulative cascade through the balance of four biochemical species and three type of platelets. SPH particles can switch from fluid to solid phase when specific biochemical and physical conditions are satisfied. The interaction between blood and the forming blood clot is easily handled by an innovative monolithic FSI approach. Fluid-solid coupling is modelled by introducing elastic binds between solid particles, without requiring detention and management of the interface between the two media. The proposed model is able to realistically reproduce the thromboembolic process, as confirmed by the comparison of numerical results with experimental data available in the literature.https://doi.org/10.1371/journal.pone.0281424 |
| spellingShingle | Alessandra Monteleone Alessia Viola Enrico Napoli Gaetano Burriesci Modelling of thrombus formation using smoothed particle hydrodynamics method. PLoS ONE |
| title | Modelling of thrombus formation using smoothed particle hydrodynamics method. |
| title_full | Modelling of thrombus formation using smoothed particle hydrodynamics method. |
| title_fullStr | Modelling of thrombus formation using smoothed particle hydrodynamics method. |
| title_full_unstemmed | Modelling of thrombus formation using smoothed particle hydrodynamics method. |
| title_short | Modelling of thrombus formation using smoothed particle hydrodynamics method. |
| title_sort | modelling of thrombus formation using smoothed particle hydrodynamics method |
| url | https://doi.org/10.1371/journal.pone.0281424 |
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