Effect of Side-Chain Functional Groups in the Immunogenicity of Bacterial Surface Glycans
Glycans on the surface of bacteria have diverse and essential biological functions and have widely been employed for treating various bacterial infectious diseases. Furthermore, these glycans comprise various functional groups, such as <i>O</i>-, <i>N</i>-, and carboxyl-modif...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/20/7112 |
| _version_ | 1797572776708538368 |
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| author | Guangzong Tian Chunjun Qin Jing Hu Xiaopeng Zou Jian Yin |
| author_facet | Guangzong Tian Chunjun Qin Jing Hu Xiaopeng Zou Jian Yin |
| author_sort | Guangzong Tian |
| collection | DOAJ |
| description | Glycans on the surface of bacteria have diverse and essential biological functions and have widely been employed for treating various bacterial infectious diseases. Furthermore, these glycans comprise various functional groups, such as <i>O</i>-, <i>N</i>-, and carboxyl-modified, which significantly increase the diversity of glycan structures. These functional groups are not only crucial for glycans’ structural identity but are also essential for their biological functions. Therefore, a clear understanding of the biological functions of these modified groups in corresponding bacterial glycans is crucial for their medical applications. Thus far, the activities of functional groups in some biomedical active carbohydrates have been elucidated. It has been shown that some functional groups are key constituents of biologically active bacterial glycans, while others are actually not essential and may even mask the functions of the glycans. This paper reviews the structures of naturally occurring side-chain functional groups in glycans located on the bacterial surface and their roles in immunological responses. |
| first_indexed | 2024-03-10T21:00:41Z |
| format | Article |
| id | doaj.art-6d041391099142e887f711a931f46ccf |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T21:00:41Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6d041391099142e887f711a931f46ccf2023-11-19T17:32:55ZengMDPI AGMolecules1420-30492023-10-012820711210.3390/molecules28207112Effect of Side-Chain Functional Groups in the Immunogenicity of Bacterial Surface GlycansGuangzong Tian0Chunjun Qin1Jing Hu2Xiaopeng Zou3Jian Yin4Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaWuxi School of Medicine, Jiangnan University, Wuxi 214122, ChinaKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaGlycans on the surface of bacteria have diverse and essential biological functions and have widely been employed for treating various bacterial infectious diseases. Furthermore, these glycans comprise various functional groups, such as <i>O</i>-, <i>N</i>-, and carboxyl-modified, which significantly increase the diversity of glycan structures. These functional groups are not only crucial for glycans’ structural identity but are also essential for their biological functions. Therefore, a clear understanding of the biological functions of these modified groups in corresponding bacterial glycans is crucial for their medical applications. Thus far, the activities of functional groups in some biomedical active carbohydrates have been elucidated. It has been shown that some functional groups are key constituents of biologically active bacterial glycans, while others are actually not essential and may even mask the functions of the glycans. This paper reviews the structures of naturally occurring side-chain functional groups in glycans located on the bacterial surface and their roles in immunological responses.https://www.mdpi.com/1420-3049/28/20/7112bacterial surface glycansfunctional groupscarbohydrate antigensbiological activitiesimmunogenicity |
| spellingShingle | Guangzong Tian Chunjun Qin Jing Hu Xiaopeng Zou Jian Yin Effect of Side-Chain Functional Groups in the Immunogenicity of Bacterial Surface Glycans Molecules bacterial surface glycans functional groups carbohydrate antigens biological activities immunogenicity |
| title | Effect of Side-Chain Functional Groups in the Immunogenicity of Bacterial Surface Glycans |
| title_full | Effect of Side-Chain Functional Groups in the Immunogenicity of Bacterial Surface Glycans |
| title_fullStr | Effect of Side-Chain Functional Groups in the Immunogenicity of Bacterial Surface Glycans |
| title_full_unstemmed | Effect of Side-Chain Functional Groups in the Immunogenicity of Bacterial Surface Glycans |
| title_short | Effect of Side-Chain Functional Groups in the Immunogenicity of Bacterial Surface Glycans |
| title_sort | effect of side chain functional groups in the immunogenicity of bacterial surface glycans |
| topic | bacterial surface glycans functional groups carbohydrate antigens biological activities immunogenicity |
| url | https://www.mdpi.com/1420-3049/28/20/7112 |
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