Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients?
Abstract Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is known to suppress the antioxidant system and is likely to aggravate severity of COVID-19, which results in a pro-oxidant response. This possible association has not been explored adequately in human studies. In this research, we report...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-98712-3 |
| _version_ | 1818845242109984768 |
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| author | Nitya Kumar AbdulKarim AbdulRahman Abdulla Ismaeel AlAwadhi Manaf AlQahtani |
| author_facet | Nitya Kumar AbdulKarim AbdulRahman Abdulla Ismaeel AlAwadhi Manaf AlQahtani |
| author_sort | Nitya Kumar |
| collection | DOAJ |
| description | Abstract Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is known to suppress the antioxidant system and is likely to aggravate severity of COVID-19, which results in a pro-oxidant response. This possible association has not been explored adequately in human studies. In this research, we report that the occurrence of non-invasive ventilation, intubation or death—all of which are indicative of severe COVID-19, are not significantly different in hospitalized COVID-19 patients with and without G6PDd (4.6 vs. 6.4%, p = 0.33). The likelihood of developing any of these severe outcomes were slightly lower in patients with G6PDd after accounting for age, nationality, presence of comorbidities and drug interventions (Odds ratio 0.40, 95% confidence intervals 0.142, 1.148). Further investigation that extends to both, hospitalized and non-hospitalized COVID-19 patients, is warranted to study this potential association. |
| first_indexed | 2024-12-19T05:26:32Z |
| format | Article |
| id | doaj.art-6d06403b22444337b64d678cb4f75700 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T05:26:32Z |
| publishDate | 2021-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6d06403b22444337b64d678cb4f757002022-12-21T20:34:21ZengNature PortfolioScientific Reports2045-23222021-09-011111710.1038/s41598-021-98712-3Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients?Nitya Kumar0AbdulKarim AbdulRahman1Abdulla Ismaeel AlAwadhi2Manaf AlQahtani3Royal College of Surgeons in IrelandMohammed Bin Khalifa Cardiac CentreBahrain Defense Force Hospital - Royal Medical ServicesRoyal College of Surgeons in IrelandAbstract Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is known to suppress the antioxidant system and is likely to aggravate severity of COVID-19, which results in a pro-oxidant response. This possible association has not been explored adequately in human studies. In this research, we report that the occurrence of non-invasive ventilation, intubation or death—all of which are indicative of severe COVID-19, are not significantly different in hospitalized COVID-19 patients with and without G6PDd (4.6 vs. 6.4%, p = 0.33). The likelihood of developing any of these severe outcomes were slightly lower in patients with G6PDd after accounting for age, nationality, presence of comorbidities and drug interventions (Odds ratio 0.40, 95% confidence intervals 0.142, 1.148). Further investigation that extends to both, hospitalized and non-hospitalized COVID-19 patients, is warranted to study this potential association.https://doi.org/10.1038/s41598-021-98712-3 |
| spellingShingle | Nitya Kumar AbdulKarim AbdulRahman Abdulla Ismaeel AlAwadhi Manaf AlQahtani Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients? Scientific Reports |
| title | Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients? |
| title_full | Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients? |
| title_fullStr | Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients? |
| title_full_unstemmed | Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients? |
| title_short | Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients? |
| title_sort | is glucose 6 phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized covid 19 patients |
| url | https://doi.org/10.1038/s41598-021-98712-3 |
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