Prevalence of Co-existing Endometrial Carcinoma in Patients with Preoperative Diagnosis of Endometrial Hyperplasia
Introduction: Endometrial hyperplasia has been associated with the presence of concomitant endometrial carcinoma. In this study, patients who were diagnosed with endometrial hyperplasia and had hysterectomy, determination of the incidence of endometrial cancer accompanying postoperatively and cl...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/6618/12484_CE(RA1)_F(T)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Introduction: Endometrial hyperplasia has been associated with
the presence of concomitant endometrial carcinoma. In this study,
patients who were diagnosed with endometrial hyperplasia and
had hysterectomy, determination of the incidence of endometrial
cancer accompanying postoperatively and clinical parameters
associated with cancer are aimed.
Materials and Methods: Endometrial biopsies were taken
from patients for various reasons and among them 158 patients
diagnosed with endometrial hyperplasia from pathologic
examination results were retrospectively evaluated. All of the
patient’s age, parity, weight, transvaginal ultrasound measured
by endometrial thickness, concomitant systemic disease
(diabetes, hypertension, hypothyroidism), tamoxifen use, hormone
use and whether in reproductive age or menopause were all
questioned. Patients who applied with endometrial cancer, their
cervical stromal involvement, lymph node involvement, cytology
positivity and omental metastases were examined. Patients were
classified according to their stage and grade. Patients who had
intraoperative frozen were re-evaluated.
Results: Fifteen cases with preoperative endometrial hyperplasia
diagnosed with endometrial cancer postoperatively, 2 cases had
complex hyperplasia without atypia and 13 cases had complex
atypical hyperplasia. The rate of preoperative hyperplasia with
postoperative endometrial cancer was found to be 10.8% where
by 15 cases of patients diagnosed with endometrial cancer
postoperatively 11 cases were in postmenopausal period. In
patients diagnosed with endometrial cancer according to their
histologic types 14 cases had endometrioid adenocarcinoma
while one patient with preoperative complex hyperplasia
without atypia was diagnosed with serous papillary carcinoma
postoperatively. Evaluation of stages in patients diagnosed with
cancer, 7 cases of patients had stage IA, 7 cases of patients had
stage IB, and 7 cases cases of patients with serous papillary
carcinoma were evaluated as stage 3C.
Conclusion: The risk of endometrial cancer in patients
diagnosed with endometrial hyperplasia especially endometrial
hyperplasia ranges between 15% to 45% and among them
7.9%–51% are found to have myometrial inversion. Therefore,
preoperative ultrasound and magnetic resonance imaging
should be perfomed in patients diagnosed with complex atypical
hyperplasia. Even intraoperative frozen section examination can
provide useful information in selected cases. |
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| ISSN: | 2249-782X 0973-709X |