The prognostic value of procalcitonin, C-reactive protein and cholesterol in patients with an infection and multiple organ dysfunction
BackgroundTo establish the prognostic value of procalcitonin, C-reactive protein and cholesterol levels for mortality in patients with an infection and multiple organ dysfunction.MethodsA prospective case-control study was performed, including 67 patients admitted to the intensive care unit with an...
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| Format: | Article |
| Language: | English |
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Korean Society of Anesthesiologists
2017-06-01
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| Series: | Korean Journal of Anesthesiology |
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| Online Access: | http://ekja.org/upload/pdf/kjae-70-305.pdf |
| _version_ | 1819008410734034944 |
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| author | Siarhei Anatolevich Tachyla Alexey Viktorovich Marochkov Artur Leonidovich Lipnitski Yulia Gennadevna Nikiforova |
| author_facet | Siarhei Anatolevich Tachyla Alexey Viktorovich Marochkov Artur Leonidovich Lipnitski Yulia Gennadevna Nikiforova |
| author_sort | Siarhei Anatolevich Tachyla |
| collection | DOAJ |
| description | BackgroundTo establish the prognostic value of procalcitonin, C-reactive protein and cholesterol levels for mortality in patients with an infection and multiple organ dysfunction.MethodsA prospective case-control study was performed, including 67 patients admitted to the intensive care unit with an infection and multiple organ dysfunction in whom cholesterol, procalcitonin, and C-reactive protein levels were measured on admission and during the course of treatment.ResultsThe associations between in-hospital mortality and procalcitonin, C-reactive protein, and cholesterol levels were analyzed. Logistic regression analysis showed that cholesterol (odds ratio [OR], 1.858; 95% CI, 1.170–2.949; P = 0.009) and C-reactive protein (OR, 4.408; 95% CI, 2.019–9.624; P < 0.001) levels were predictors of mortality. A receiver operating characteristic curve analysis yielded an area under the curve (AUC) of 0.774 and 95% CI of 0.693–0.855 (P < 0.001) for C-reactive protein, an AUC of 0.66 and 95% CI of 0.535–0.784 (P = 0.019) for procalcitonin, and an AUC of 0.654 and 95% CI of 0.593–0.715 (P < 0.001) for cholesterol as predictors of mortality. When combined with the bioscore system for mortality, these markers yielded an AUC of 0.845 and 95% CI of 0.770–0.921 (P < 0.001), with sensitivity of 89.1% and specificity of 83.1%.ConclusionsThe combination of procalcitonin, C-reactive protein, and cholesterol levels in a single scoring system yielded high predictive value for mortality. |
| first_indexed | 2024-12-21T00:40:02Z |
| format | Article |
| id | doaj.art-6d092076876f4c58a7ee752640581f23 |
| institution | Directory Open Access Journal |
| issn | 2005-6419 2005-7563 |
| language | English |
| last_indexed | 2024-12-21T00:40:02Z |
| publishDate | 2017-06-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Korean Journal of Anesthesiology |
| spelling | doaj.art-6d092076876f4c58a7ee752640581f232022-12-21T19:21:43ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632017-06-0170330531010.4097/kjae.2017.70.3.3058301The prognostic value of procalcitonin, C-reactive protein and cholesterol in patients with an infection and multiple organ dysfunctionSiarhei Anatolevich Tachyla0Alexey Viktorovich Marochkov1Artur Leonidovich Lipnitski2Yulia Gennadevna Nikiforova3Department of Anesthesiology and Intensive Care, Mogilev Regional Hospital, Mogilev, Belarus.Department of Anesthesiology and Intensive Care, Mogilev Regional Hospital, Mogilev, Belarus.Department of Anesthesiology and Intensive Care, Mogilev Regional Hospital, Mogilev, Belarus.Department of Anesthesiology and Intensive Care, Mogilev Regional Hospital, Mogilev, Belarus.BackgroundTo establish the prognostic value of procalcitonin, C-reactive protein and cholesterol levels for mortality in patients with an infection and multiple organ dysfunction.MethodsA prospective case-control study was performed, including 67 patients admitted to the intensive care unit with an infection and multiple organ dysfunction in whom cholesterol, procalcitonin, and C-reactive protein levels were measured on admission and during the course of treatment.ResultsThe associations between in-hospital mortality and procalcitonin, C-reactive protein, and cholesterol levels were analyzed. Logistic regression analysis showed that cholesterol (odds ratio [OR], 1.858; 95% CI, 1.170–2.949; P = 0.009) and C-reactive protein (OR, 4.408; 95% CI, 2.019–9.624; P < 0.001) levels were predictors of mortality. A receiver operating characteristic curve analysis yielded an area under the curve (AUC) of 0.774 and 95% CI of 0.693–0.855 (P < 0.001) for C-reactive protein, an AUC of 0.66 and 95% CI of 0.535–0.784 (P = 0.019) for procalcitonin, and an AUC of 0.654 and 95% CI of 0.593–0.715 (P < 0.001) for cholesterol as predictors of mortality. When combined with the bioscore system for mortality, these markers yielded an AUC of 0.845 and 95% CI of 0.770–0.921 (P < 0.001), with sensitivity of 89.1% and specificity of 83.1%.ConclusionsThe combination of procalcitonin, C-reactive protein, and cholesterol levels in a single scoring system yielded high predictive value for mortality.http://ekja.org/upload/pdf/kjae-70-305.pdfcholesterolc-reactive proteininfectionmortalitymultiple organ dysfunctionprocalcitonin |
| spellingShingle | Siarhei Anatolevich Tachyla Alexey Viktorovich Marochkov Artur Leonidovich Lipnitski Yulia Gennadevna Nikiforova The prognostic value of procalcitonin, C-reactive protein and cholesterol in patients with an infection and multiple organ dysfunction Korean Journal of Anesthesiology cholesterol c-reactive protein infection mortality multiple organ dysfunction procalcitonin |
| title | The prognostic value of procalcitonin, C-reactive protein and cholesterol in patients with an infection and multiple organ dysfunction |
| title_full | The prognostic value of procalcitonin, C-reactive protein and cholesterol in patients with an infection and multiple organ dysfunction |
| title_fullStr | The prognostic value of procalcitonin, C-reactive protein and cholesterol in patients with an infection and multiple organ dysfunction |
| title_full_unstemmed | The prognostic value of procalcitonin, C-reactive protein and cholesterol in patients with an infection and multiple organ dysfunction |
| title_short | The prognostic value of procalcitonin, C-reactive protein and cholesterol in patients with an infection and multiple organ dysfunction |
| title_sort | prognostic value of procalcitonin c reactive protein and cholesterol in patients with an infection and multiple organ dysfunction |
| topic | cholesterol c-reactive protein infection mortality multiple organ dysfunction procalcitonin |
| url | http://ekja.org/upload/pdf/kjae-70-305.pdf |
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