4-(2,5-Dimethyl-1<i>H</i>-pyrrol-1-yl)-1,2,5-oxadiazol-3-amine

4-(2,5-Dimethyl-1<i>H</i>-pyrrol-1-yl)-1,2,5-oxadiazol-3-amine

1,2,5-Oxadiazol-3-amines with a heterocyclic substituent in the 4-position are being intensively investigated as compounds with valuable pharmacological activity. In this communication, the reaction of 1,2,5-oxadiazole-3,4-diamine with 2,5-hexanedione was shown to selectively give 4-(2,5-dimethyl-1&...

Full description

Bibliographic Details
Main Authors:	Natalia V. Obruchnikova, Oleg A. Rakitin
Format:	Article
Language:	English
Published:	MDPI AG 2023-07-01
Series:	Molbank
Subjects:	1,2,5-oxadiazoles 1,2,5-oxadiazole-3,4-diamine Paal–Knorr reaction 2,5-hexanedione
Online Access:	https://www.mdpi.com/1422-8599/2023/3/M1700

Similar Items

4,4′-Difluoro-[3,3′-bi(1,2,5-oxadiazole)] 2,2′-Dioxide
by: Natalia V. Obruchnikova, et al.
Published: (2023-02-01)

Design and Synthesis of New Boron-Based Benzo[c][1,2,5]oxadiazoles and Benzo[c][1,2,5]thiadiazoles as Potential Hypoxia Inhibitors
by: Sasmita Das, et al.
Published: (2023-01-01)

Anions Containing Tripoid Conjugated N<sub>4</sub><sup>−</sup> System: Salts of 5-(Substituted Amino)-[1,2,3]triazolo[4,5-<i>c</i>][1,2,5]oxadiazol-5-ium-4-ides, as well as Their Synthesis, Structure, and Thermal Stability
by: Alexey A. Voronin, et al.
Published: (2022-09-01)

3,3′-(Diazene-1,2-diyl)bis[4-(nitroamino)-1,2,5-oxadiazole 2-oxide]
by: Alexander Larin, et al.
Published: (2018-07-01)

Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review
by: Jing-Jing Wang, et al.
Published: (2022-12-01)

Simple and energetic: Novel combination of furoxan and 1,2,4-triazole rings in the synthesis of energetic materials
by: Alexander A. Larin, et al.
Published: (2022-09-01)

7-Bromo-[1,2,5]selenadiazolo[3,4-<i>d</i>]pyridazin-4(5<i>H</i>)-one
by: Timofey N. Chmovzh, et al.
Published: (2021-06-01)

Composite Sorbents Based on Chitosan Polymer Matrix and Derivatives of 4-Amino-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide for Uranium Removal from Liquid Mineralized Media
by: Anna I. Matskevich, et al.
Published: (2025-01-01)

5,6-Dihydro-[1,2,5]oxadiazolo[3,4-<i>d</i>]pyridazine-4,7-dione
by: Timofey N. Chmovzh, et al.
Published: (2023-05-01)

Tandem diazotization/cyclization approach for the synthesis of a fused 1,2,3-triazinone-furazan/furoxan heterocyclic system
by: Yuri A. Sidunets, et al.
Published: (2024-09-01)

Nitro-, Cyano-, and Methylfuroxans, and Their Bis-Derivatives: From Green Primary to Melt-Cast Explosives
by: Alexander A. Larin, et al.
Published: (2020-12-01)

4,7-Dichloro[1,2,5]oxadiazolo[3,4-d]pyridazine 1-oxide
by: Timofey Chmovzh, et al.
Published: (2018-02-01)

Synthesis of energetic coordination polymers based on 4-nitropyrazole by solid-melt crystallization in non-ionization condition
by: Ting-wei Wang, et al.
Published: (2023-10-01)

Synthesis, Characterization and Biological Investigation of Some New Hydroxy – 1,3,4 – Oxadiazole Derivatives
by: Afraa S. S, et al.
Published: (2016-09-01)

Synthesis, Characterization and study biologicalactivity of several 1-cyclopentene-1,2-dicarboxylimidyl Containing oxadiazole and Benzothiazole
by: Baghdad Science Journal
Published: (2014-06-01)

Antimicrobial activities of pyridinium-tailored pyrazoles bearing 1,3,4-oxadiazole scaffolds
by: Lei Zhou, et al.
Published: (2017-11-01)

Synthesis of Some New Heterocyclic Fused Rings Compounds Based on 5-Aryl-1,3,4-Oxadiazole
by: Zahra Mohammed Abbas, et al.
Published: (2017-09-01)

Transformation of 3-(Furan-2-yl)-1,3-di(het)arylpropan-1-ones to Prop-2-en-1-ones via Oxidative Furan Dearomatization/2-Ene-1,4,7-triones Cyclization
by: Roman O. Shcherbakov, et al.
Published: (2021-04-01)

3-(3,4-Dichlorophenyl)-5-(1<i>H</i>-indol-5-yl)-1,2,4-oxadiazole
by: Julia A. Efimova, et al.
Published: (2023-01-01)

(<i>E</i>)-2-(6-(4′-(Diphenylamino)-[1,1′-biphenyl]-2-yl)-[1,2,5]oxadiazolo[3,4-<i>b</i>]pyrazin-5(4<i>H</i>)-ylidene)-2-(6-(4′-(diphenylamino)-[1,1′-biphenyl]-2-yl)-[1,2,5]oxadiazolo[3,4-<i>b</i>]pyrazin-5-yl)acetonitrile
by: Yuriy A. Kvashnin, et al.
Published: (2023-08-01)

Novel benzodioxatriaza and dibenzodioxadiazacrown compounds carrying 1,2,4-oxadiazole moiety
by: Özer Besra, et al.
Published: (2022-09-01)

Tuning the Solubility Parameters of Carbon Nanotubes by Means of Their Adducts with <i>Janus</i> Pyrrole Compounds
by: Daniele Locatelli, et al.
Published: (2020-06-01)

Synthesis of New 1, 3, 4-Oxadiazole-Incorporated 1, 2, 3-Triazole Moieties as Potential Anticancer Agents Targeting Thymidylate Synthase and Their Docking Studies
by: Mohammad Mahboob Alam, et al.
Published: (2020-11-01)

2,5-Hexanedione Affects Ovarian Granulosa Cells in Swine by Regulating the <i>CDKN1A</i> Gene: A Transcriptome Analysis
by: Yige Chen, et al.
Published: (2023-03-01)

TiO2-coated graphene oxide-molybdate complex as a new separable nanocatalyst for the synthesis of pyrrole derivatives by Paal-Knorr reaction
by: Raziyeh Keshavarz, et al.
Published: (2022-05-01)

Synthesis of new 3-(4-methyl-2-arylthiazol-5-yl)-5-aryl-1,2,4-oxadiazole derivatives as potential cytotoxic and antimicrobial agents
by: Abdul Latif N. Shaikh, et al.
Published: (2022-12-01)

Synthesis of 1,2,4-Oxadiazoles Based on Diffractaic Acid
by: Aleksandr Filimonov, et al.
Published: (2024-11-01)

Discovery of Novel 1,2,4-Oxadiazole Derivatives as Potent Caspase-3 Activator for Cancer Treatment
by: Ankur Vaidya
Published: (2021-03-01)

In vitro antitumor and immunomodulatory activities of 1,2,4-oxadiazole derivatives
by: Héverton Mendes Araújo, et al.
Published: (2025-03-01)

DFT Study of Molecular and Electronic Structure of Y, La and Lu Complexes with Porphyrazine and Tetrakis(1,2,5-thiadiazole)porphyrazine
by: Yuriy A. Zhabanov, et al.
Published: (2020-12-01)

Donor-Acceptor Copolymers with 9-(2-Ethylhexyl)carbazole or Dibenzothiophene-5,5-dioxide Donor Units and 5,6-Difluorobenzo[<i>c</i>][1,2,5]thiadiazole Acceptor Units for Photonics
by: Věra Cimrová, et al.
Published: (2023-11-01)

1,2,5-Thiadiazole 1,1-dioxides and Their Radical Anions: Structure, Properties, Reactivity, and Potential Use in the Construction of Functional Molecular Materials
by: Paweł Pakulski, et al.
Published: (2021-08-01)

A Handy and Solventless Direct Route to Primary 3-[3-Aryl)-1,2,4-oxadiazol-5-yl]propionamides Using Microwave Irradiation
by: Rajendra M. Srivastava, et al.
Published: (2006-05-01)

Reverse-Phase Chromatographic Determination and Intrinsic Stability Behavior of 5-[(4-Chlorophenoxy)Methyl]-1,3,4-Oxadiazole-2-Thiol
by: Shehzadi Naureen, et al.
Published: (2018-12-01)

The synthesis and biological assessment of [[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides with an 1,2,4-oxadiazol cycle in positions 6, 7 and 8
by: V. R. Karpina, et al.
Published: (2019-02-01)

Synthesis and biological evaluation of aryl 1,2,4-oxadiazole incorporated (2-(oxazol)-1H-imidazoles as anticancer agents
by: Suresh Bairi, et al.
Published: (2022-01-01)

Composite Sorbents Based on Polymeric Se-Derivative of Amidoximes and SiO<sub>2</sub> for the Uranium Removal from Liquid Mineralized Media
by: Anna I. Matskevich, et al.
Published: (2024-12-01)

5-Nitrotetrazol and 1,2,4-Oxadiazole Methylene-Bridged Energetic Compounds: Synthesis, Crystal Structures and Performances
by: Jiarong Zhang, et al.
Published: (2021-11-01)

Unique mode of binding between angiotensin II type 1 receptor and its blockers
by: Yoshino Matsuo, et al.
Published: (2019-11-01)

Benzamides Substituted with Quinoline-Linked 1,2,4-Oxadiazole: Synthesis, Biological Activity and Toxicity to Zebrafish Embryo
by: Bin-Long Sun, et al.
Published: (2022-06-01)