Phillyrin ameliorated collagen-induced arthritis through inhibition of NF-κB and MAPKs pathways in fibroblast-like synoviocytes

Phillyrin ameliorated collagen-induced arthritis through inhibition of NF-κB and MAPKs pathways in fibroblast-like synoviocytes

The discovery of alternative medicines with less adverse effects is extremely urgent for rheumatoid arthritis (RA). Phillyrin (Phil), the predominant lignan glycoside of Forsythia suspensa, has been reported to exert several pharmacological effects, such as antivirus, anti-inflammation, anti-oxidati...

Full description

Bibliographic Details
Main Authors:	Gang Chen, Yuhang Mao, Jing Wang, Junnan Zhou, Li Diao, Sirui Wang, Wenjuan Zhao, Xinyi Zhu, Xiaolu Yu, Fuli Zhao, Xuan Liu, Mei Liu
Format:	Article
Language:	English
Published:	Elsevier 2023-08-01
Series:	Arabian Journal of Chemistry
Subjects:	Phillyrin Rheumatoid arthritis Collagen-induced arthritis Fibroblast-like synoviocyte
Online Access:	http://www.sciencedirect.com/science/article/pii/S1878535223003064

Similar Items

Review on the Pharmacological Properties of Phillyrin
by: Chenyu Zhou, et al.
Published: (2022-06-01)

Comparative Transcriptome Analysis of MeJA Responsive Enzymes Involved in Phillyrin Biosynthesis of <i>Forsythia suspensa</i>
by: Xiaoran Liu, et al.
Published: (2022-11-01)

Production and Secretion of Gelsolin by Both Human Macrophage- and Fibroblast-like Synoviocytes and GSN Modulation in the Synovial Fluid of Patients with Various Forms of Arthritis
by: Jessica Feldt, et al.
Published: (2022-03-01)

Morphofunctional analysis of fibroblast-like synoviocytes in human rheumatoid arthritis and mouse collagen-induced arthritis
by: Camilla Ribeiro Lima Machado, et al.
Published: (2023-01-01)

Immunological Roles of Fibroblast-Like Synoviocyte Cells in Rheumatoid Arthritis
by: Mohammad Reza Royaei, et al.
Published: (2024-04-01)

PLD1 knockdown reduces metastasis and inflammation of fibroblast-like synoviocytes in rheumatoid arthritis by modulating NF-κB and Wnt/β-catenin pathways
by: Zhengyu Zhang, et al.
Published: (2021-10-01)

Dimethyl Sulfoxide: A Bio-Friendly or Bio-Hazard Chemical? The Effect of DMSO in Human Fibroblast-like Synoviocytes
by: Manuel Gallardo-Villagrán, et al.
Published: (2022-07-01)

Phillyrin attenuates airway inflammation and Th2 cell activities in a mouse asthma model
by: Wen-Chung Huang, et al.
Published: (2023-12-01)

Peficitinib Inhibits the Chemotactic Activity of Monocytes via Proinflammatory Cytokine Production in Rheumatoid Arthritis Fibroblast-Like Synoviocytes
by: Yuzo Ikari, et al.
Published: (2019-06-01)

Single-cell analysis reveals heterogeneity of juvenile idiopathic arthritis fibroblast-like synoviocytes with implications for disease subtype
by: Megan M. Simonds, et al.
Published: (2022-09-01)

Fermented Lettuce Extract Containing Nitric Oxide Metabolites Attenuates Inflammatory Parameters in Model Mice and in Human Fibroblast-Like Synoviocytes
by: Jisu Park, et al.
Published: (2023-02-01)

Phillyrin ameliorates influenza a virus-induced pulmonary inflammation by antagonizing CXCR2 and inhibiting NLRP3 inflammasome activation
by: Shanyu Zhang, et al.
Published: (2023-11-01)

Morphological and Mechanical Characterization of Extracellular Vesicles and Parent Human Synoviocytes under Physiological and Inflammatory Conditions
by: Samira Filali, et al.
Published: (2022-10-01)

LncRNA HOTAIR inhibits the progression of fibroblast-like synoviocytes by sponging miRNA-106b-5p in rheumatoid arthritis
by: Hongxia Qiu, et al.
Published: (2022-11-01)

2-Styrylchromones Inhibit IL-1β-Induced Inflammatory Mediators’ Production in Human Fibroblast-like Synoviocytes
by: Ana Teresa Rufino, et al.
Published: (2022-11-01)

Adalimumab Effectively Decreases Inflammation Downstream of TNFα Signaling in Synoviocytes from Extended Oligoarticular Juvenile Idiopathic Arthritis
by: Megan M. Simonds, et al.
Published: (2023-12-01)

LKB1 Regulates Inflammation of Fibroblast-like Synoviocytes from Patients with Rheumatoid Arthritis via AMPK-Dependent SLC7A11-NOX4-ROS Signaling
by: Ha-Reum Lee, et al.
Published: (2023-04-01)

Metabolic changes in fibroblast-like synoviocytes in rheumatoid arthritis: state of the art review
by: Zhipeng Hu, et al.
Published: (2024-02-01)

The Biological Effects of Forsythia Leaves Containing the Cyclic AMP Phosphodiesterase 4 Inhibitor Phillyrin
by: Sansei Nishibe, et al.
Published: (2021-04-01)

SMAD2 inhibits pyroptosis of fibroblast-like synoviocytes and secretion of inflammatory factors via the TGF-β pathway in rheumatoid arthritis
by: Xingxing Mao, et al.
Published: (2023-08-01)

PROBLEMS OF EPIGENOME IN RHEUMATOID ARTHRITIS
by: V A Kozlov
Published: (2011-06-01)

Artemisitene suppresses rheumatoid arthritis progression via modulating METTL3‐mediated N6‐methyladenosine modification of ICAM2 mRNA in fibroblast‐like synoviocytes
by: Jian Chen, et al.
Published: (2022-12-01)

Fatty Acid Fingerprints and Hyaluronic Acid in Extracellular Vesicles from Proliferating Human Fibroblast-like Synoviocytes
by: Anne-Mari Mustonen, et al.
Published: (2022-05-01)

Circ_0002984 promotes proliferation, migration and inflammatory cytokine secretion and inhibits apoptosis of rheumatoid arthritis fibroblast-like synoviocytes by inducing PCSK6 through miR-543
by: Jian-zuo Lu, et al.
Published: (2023-05-01)

LncRNA FOXD2-AS1 promotes cell proliferation and invasion of fibroblast-like synoviocytes by regulation of miR-331-3p/PIAS3 pathway in rheumatoid arthritis
by: Qirui Zhao, et al.
Published: (2021-07-01)

Benzylideneacetophenone Derivative Alleviates Arthritic Symptoms via Modulation of the MAPK Signaling Pathway
by: Bongjun Sur, et al.
Published: (2020-07-01)

MicroRNA-27a-3p enhances the inflammatory phenotype of Juvenile Idiopathic Arthritis fibroblast-like synoviocytes
by: Claire H. Bullock, et al.
Published: (2023-06-01)

Akuammiline alkaloid derivatives: divergent synthesis and effect on the proliferation of rheumatoid arthritis fibroblast-like synoviocytes
by: Xinye Bao, et al.
Published: (2023-04-01)

Effect of curcumin on the expression of NOD2 receptor and pro-inflammatory cytokines in fibroblast-like synoviocytes (FLSs) of rheumatoid arthritis (RA) patients
by: Fereshteh Akbari-Papkiadehi, et al.
Published: (2023-06-01)

Role and mechanism of fibroblast-activated protein-α expression on the surface of fibroblast-like synoviocytes in rheumatoid arthritis
by: Zihan Wang, et al.
Published: (2023-03-01)

Sodium propionate improves rheumatoid arthritis by inhibiting survivin mediated proliferation of fibroblast like synoviocytes by promoting miR-140-5p
by: Sha Ma, et al.
Published: (2022-08-01)

Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway
by: Dong Guo, et al.
Published: (2023-11-01)

14-3-3η Promotes Invadosome Formation via the FOXO3–Snail Axis in Rheumatoid Arthritis Fibroblast-like Synoviocytes
by: Maleck Kadiri, et al.
Published: (2021-12-01)

Protocatechuic acid reduces H2O2-induced migration and oxidative stress of fibroblast-like synoviocytes in rheumatoid arthritis by activating Nrf2-Keap1 signaling pathway
by: Yan Liu, et al.
Published: (2023-01-01)

2-Styrylchromones Prevent IL-1β-Induced Pro-Inflammatory Activation of Fibroblast-like Synoviocytes while Increasing COX-2 Expression
by: Ana Teresa Rufino, et al.
Published: (2023-02-01)

Anti-Inflammatory Effects of Endogenously Released Adenosine in Synovial Cells of Osteoarthritis and Rheumatoid Arthritis Patients
by: Rebecca Sohn, et al.
Published: (2021-08-01)

Nitazoxanide reduces inflammation and bone erosion in mice with collagen-induced arthritis via inhibiting the JAK2/STAT3 and NF-κB pathways in fibroblast-like synoviocytes
by: Changhong Li, et al.
Published: (2024-02-01)

Cationic amino acid transporter-1 (CAT-1) promotes fibroblast-like synoviocyte proliferation and cytokine secretion by taking up L-arginine in rheumatoid arthritis
by: Ying Lu, et al.
Published: (2022-10-01)

Bromelain Extract Exerts Antiarthritic Effects via Chondroprotection and the Suppression of TNF-α–Induced NF-κB and MAPK Signaling
by: Peraphan Pothacharoen, et al.
Published: (2021-10-01)

Methyl Canthin-6-one-2-carboxylate Restrains the Migration/Invasion Properties of Fibroblast-like Synoviocytes by Suppressing the Hippo/YAP Signaling Pathway
by: Zongying Zhang, et al.
Published: (2023-10-01)