Identification and functional characterization of ORF19.5274, a novel gene involved in both azoles susceptibility and hypha development in Candida albicans

Identification and functional characterization of ORF19.5274, a novel gene involved in both azoles susceptibility and hypha development in Candida albicans

Azole resistance is becoming increasingly serious due to the frequent recurrence of fungal infections and the need for long-term clinical prevention. In our previous study, we discovered ORF19.5274 with an unknown function by TMT™ quantitative proteomics technology after fluconazole (FLC) treatment...

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Bibliographic Details
Main Authors: Mingjiao Huang, Longbing Yang, Luoxiong Zhou, Chaoqin Sun, Wenjing Zhao, Jian Peng, Zhenlong Jiao, Chunren Tian, Guo Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Microbiology
Subjects:
Candida albicans
ORF19.5274
azole resistance
ergosterol
Galleria mellonella
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.990318/full

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