From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress?
The concepts of allostatic load and overload, i. e., a dramatic increase in the allostatic load that predisposes to disease, have been extensively described in the literature. Here, we show that rats engaging in active offensive response (AOR) behavioral strategies to chronic predator scent stress (...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnbeh.2019.00047/full |
| _version_ | 1819238842464468992 |
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| author | Enrico Ullmann Enrico Ullmann Enrico Ullmann Seth W. Perry Julio Licinio Ma-Li Wong Eliyahu Dremencov Eliyahu Dremencov Eliyahu Dremencov Evgenii L. Zavjalov Oleg B. Shevelev Nikita V. Khotskin Galina V. Koncevaya Anna S. Khotshkina Mikhail P. Moshkin Maxim S. Lapshin Maria V. Komelkova Inna V. Feklicheva Olga B. Tseilikman Olga P. Cherkasova Kamaldeep S. Bhui Edgar Jones Clemens Kirschbaum Stefan R. Bornstein Stefan R. Bornstein Vadim Tseilikman |
| author_facet | Enrico Ullmann Enrico Ullmann Enrico Ullmann Seth W. Perry Julio Licinio Ma-Li Wong Eliyahu Dremencov Eliyahu Dremencov Eliyahu Dremencov Evgenii L. Zavjalov Oleg B. Shevelev Nikita V. Khotskin Galina V. Koncevaya Anna S. Khotshkina Mikhail P. Moshkin Maxim S. Lapshin Maria V. Komelkova Inna V. Feklicheva Olga B. Tseilikman Olga P. Cherkasova Kamaldeep S. Bhui Edgar Jones Clemens Kirschbaum Stefan R. Bornstein Stefan R. Bornstein Vadim Tseilikman |
| author_sort | Enrico Ullmann |
| collection | DOAJ |
| description | The concepts of allostatic load and overload, i. e., a dramatic increase in the allostatic load that predisposes to disease, have been extensively described in the literature. Here, we show that rats engaging in active offensive response (AOR) behavioral strategies to chronic predator scent stress (PSS) display less anxiety behavior and lower plasma cortisol levels vs. rats engaging in passive defensive response (PDR) behavioral strategies to chronic PSS. In the same chronic PSS paradigm, AOR rats also have higher lactate and lower glutamate levels in amygdala but not in control-region hippocampus vs. PDR rats. The implications of these findings for regulation of allostatic and stress responses, and post-traumatic stress disorder (PTSD) are discussed. |
| first_indexed | 2024-12-23T13:42:39Z |
| format | Article |
| id | doaj.art-6d0c416bb24340de86eb61bd8e4bf402 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-23T13:42:39Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-6d0c416bb24340de86eb61bd8e4bf4022022-12-21T17:44:49ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532019-03-011310.3389/fnbeh.2019.00047423690From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress?Enrico Ullmann0Enrico Ullmann1Enrico Ullmann2Seth W. Perry3Julio Licinio4Ma-Li Wong5Eliyahu Dremencov6Eliyahu Dremencov7Eliyahu Dremencov8Evgenii L. Zavjalov9Oleg B. Shevelev10Nikita V. Khotskin11Galina V. Koncevaya12Anna S. Khotshkina13Mikhail P. Moshkin14Maxim S. Lapshin15Maria V. Komelkova16Inna V. Feklicheva17Olga B. Tseilikman18Olga P. Cherkasova19Kamaldeep S. Bhui20Edgar Jones21Clemens Kirschbaum22Stefan R. Bornstein23Stefan R. Bornstein24Vadim Tseilikman25Department of Medicine, Carl Gustav Carus, Technical University of Dresden, Dresden, GermanyDepartment of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University of Leipzig, Leipzig, GermanySchool of Medical Biology, South Ural State University, Chelyabinsk, RussiaCollege of Medicine, SUNY Upstate Medical University, Syracuse, NY, United StatesCollege of Medicine, SUNY Upstate Medical University, Syracuse, NY, United StatesCollege of Medicine, SUNY Upstate Medical University, Syracuse, NY, United StatesSchool of Medical Biology, South Ural State University, Chelyabinsk, RussiaInstitute of Molecular Physiology and Genetics, Centre for Biosciences, Slovak Academy of Sciences, Bratislava, SlovakiaBiomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, SlovakiaInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science (RAS), Novosibirsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science (RAS), Novosibirsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science (RAS), Novosibirsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science (RAS), Novosibirsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science (RAS), Novosibirsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science (RAS), Novosibirsk, RussiaSchool of Medical Biology, South Ural State University, Chelyabinsk, RussiaSchool of Medical Biology, South Ural State University, Chelyabinsk, RussiaSchool of Medical Biology, South Ural State University, Chelyabinsk, RussiaSchool of Medical Biology, South Ural State University, Chelyabinsk, RussiaBiophysics Laboratory, Institute of Laser Physics, Siberian Branch of the Russian Academy of Science, Novosibirsk, RussiaCentre for Psychiatry, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, United Kingdom0Institute of Psychiatry Psychology & Neuroscience, King's College London, London, United Kingdom1Department of Psychology, Biopsychology, Technical University of Dresden, Dresden, GermanyDepartment of Medicine, Carl Gustav Carus, Technical University of Dresden, Dresden, Germany2Faculty of Life Sciences & Medicine, Endocrinology and Diabetes, Kings College London, London, United KingdomSchool of Medical Biology, South Ural State University, Chelyabinsk, RussiaThe concepts of allostatic load and overload, i. e., a dramatic increase in the allostatic load that predisposes to disease, have been extensively described in the literature. Here, we show that rats engaging in active offensive response (AOR) behavioral strategies to chronic predator scent stress (PSS) display less anxiety behavior and lower plasma cortisol levels vs. rats engaging in passive defensive response (PDR) behavioral strategies to chronic PSS. In the same chronic PSS paradigm, AOR rats also have higher lactate and lower glutamate levels in amygdala but not in control-region hippocampus vs. PDR rats. The implications of these findings for regulation of allostatic and stress responses, and post-traumatic stress disorder (PTSD) are discussed.https://www.frontiersin.org/article/10.3389/fnbeh.2019.00047/fullbehaviorstress-diseasesallostasis/homeostasisglutamatePTSD (post-traumatic stress disorder) |
| spellingShingle | Enrico Ullmann Enrico Ullmann Enrico Ullmann Seth W. Perry Julio Licinio Ma-Li Wong Eliyahu Dremencov Eliyahu Dremencov Eliyahu Dremencov Evgenii L. Zavjalov Oleg B. Shevelev Nikita V. Khotskin Galina V. Koncevaya Anna S. Khotshkina Mikhail P. Moshkin Maxim S. Lapshin Maria V. Komelkova Inna V. Feklicheva Olga B. Tseilikman Olga P. Cherkasova Kamaldeep S. Bhui Edgar Jones Clemens Kirschbaum Stefan R. Bornstein Stefan R. Bornstein Vadim Tseilikman From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress? Frontiers in Behavioral Neuroscience behavior stress-diseases allostasis/homeostasis glutamate PTSD (post-traumatic stress disorder) |
| title | From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress? |
| title_full | From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress? |
| title_fullStr | From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress? |
| title_full_unstemmed | From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress? |
| title_short | From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress? |
| title_sort | from allostatic load to allostatic state an endogenous sympathetic strategy to deal with chronic anxiety and stress |
| topic | behavior stress-diseases allostasis/homeostasis glutamate PTSD (post-traumatic stress disorder) |
| url | https://www.frontiersin.org/article/10.3389/fnbeh.2019.00047/full |
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