Landscape of Statin as a Cornerstone in Atherosclerotic Cardiovascular Disease
Atherosclerosis, the key pathogenesis of cardiovascular disease, is a leading cause of death and disability worldwide. Statins are first-line lipid-lowering drugs, which have been demonstrated to be powerful agents for anti-atherosclerosis. Numerous studies have confirmed the cardiovascular benefits...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2023-12-01
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| Series: | Reviews in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/RCM/24/12/10.31083/j.rcm2412373 |
| _version_ | 1827390137982517248 |
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| author | Cheng Yang Yong-Jian Wu Jie Qian Jian-Jun Li |
| author_facet | Cheng Yang Yong-Jian Wu Jie Qian Jian-Jun Li |
| author_sort | Cheng Yang |
| collection | DOAJ |
| description | Atherosclerosis, the key pathogenesis of cardiovascular disease, is a leading cause of death and disability worldwide. Statins are first-line lipid-lowering drugs, which have been demonstrated to be powerful agents for anti-atherosclerosis. Numerous studies have confirmed the cardiovascular benefits and long-term safety of statins in a wide range of patients. Statins play an indispensable and irreplaceable part in the prevention and treatment of atherosclerotic cardiovascular disease (ASCVD). In this article, we summarize the evolution of statins and their role in the treatment of cholesterol. The anti-atherosclerotic mechanism of statins, its efficacy, safety and clinical outcomes in secondary and primary prevention of ACSVD in different patient populations, the combination treatment effects, and guideline recommendations are also detailed. This paper highlights the profound significance of statins as the most successful anti-atherogenic drug in the cardiovascular field. |
| first_indexed | 2024-03-08T16:47:05Z |
| format | Article |
| id | doaj.art-6d0c4676b9b740b48a87f72dad08f238 |
| institution | Directory Open Access Journal |
| issn | 1530-6550 |
| language | English |
| last_indexed | 2024-03-08T16:47:05Z |
| publishDate | 2023-12-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj.art-6d0c4676b9b740b48a87f72dad08f2382024-01-05T09:04:31ZengIMR PressReviews in Cardiovascular Medicine1530-65502023-12-01241237310.31083/j.rcm2412373S1530-6550(23)01210-3Landscape of Statin as a Cornerstone in Atherosclerotic Cardiovascular DiseaseCheng Yang0Yong-Jian Wu1Jie Qian2Jian-Jun Li3State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037 Beijing, ChinaState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037 Beijing, ChinaState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037 Beijing, ChinaState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037 Beijing, ChinaAtherosclerosis, the key pathogenesis of cardiovascular disease, is a leading cause of death and disability worldwide. Statins are first-line lipid-lowering drugs, which have been demonstrated to be powerful agents for anti-atherosclerosis. Numerous studies have confirmed the cardiovascular benefits and long-term safety of statins in a wide range of patients. Statins play an indispensable and irreplaceable part in the prevention and treatment of atherosclerotic cardiovascular disease (ASCVD). In this article, we summarize the evolution of statins and their role in the treatment of cholesterol. The anti-atherosclerotic mechanism of statins, its efficacy, safety and clinical outcomes in secondary and primary prevention of ACSVD in different patient populations, the combination treatment effects, and guideline recommendations are also detailed. This paper highlights the profound significance of statins as the most successful anti-atherogenic drug in the cardiovascular field.https://www.imrpress.com/journal/RCM/24/12/10.31083/j.rcm2412373statinscardiovascular diseaselipid-loweringcornerstone |
| spellingShingle | Cheng Yang Yong-Jian Wu Jie Qian Jian-Jun Li Landscape of Statin as a Cornerstone in Atherosclerotic Cardiovascular Disease Reviews in Cardiovascular Medicine statins cardiovascular disease lipid-lowering cornerstone |
| title | Landscape of Statin as a Cornerstone in Atherosclerotic Cardiovascular Disease |
| title_full | Landscape of Statin as a Cornerstone in Atherosclerotic Cardiovascular Disease |
| title_fullStr | Landscape of Statin as a Cornerstone in Atherosclerotic Cardiovascular Disease |
| title_full_unstemmed | Landscape of Statin as a Cornerstone in Atherosclerotic Cardiovascular Disease |
| title_short | Landscape of Statin as a Cornerstone in Atherosclerotic Cardiovascular Disease |
| title_sort | landscape of statin as a cornerstone in atherosclerotic cardiovascular disease |
| topic | statins cardiovascular disease lipid-lowering cornerstone |
| url | https://www.imrpress.com/journal/RCM/24/12/10.31083/j.rcm2412373 |
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