Multiple Primary Melanomas: Retrospective Review in a Tertiary Care Hospital
Multiple primary melanomas (MPM) refer to the occurrence of more than one synchronous or metachronous melanoma in the same individual. The aim of this study was to identify the frequency of MPM and describe the clinical and histopathologic characteristics of patients with MPM. An observational singl...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/9/2355 |
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| author | Rodolfo David Palacios-Diaz Blanca de Unamuno-Bustos Carlos Abril-Pérez Mónica Pozuelo-Ruiz Javier Sánchez-Arraez Ignacio Torres-Navarro Rafael Botella-Estrada |
| author_facet | Rodolfo David Palacios-Diaz Blanca de Unamuno-Bustos Carlos Abril-Pérez Mónica Pozuelo-Ruiz Javier Sánchez-Arraez Ignacio Torres-Navarro Rafael Botella-Estrada |
| author_sort | Rodolfo David Palacios-Diaz |
| collection | DOAJ |
| description | Multiple primary melanomas (MPM) refer to the occurrence of more than one synchronous or metachronous melanoma in the same individual. The aim of this study was to identify the frequency of MPM and describe the clinical and histopathologic characteristics of patients with MPM. An observational single-center retrospective study was designed based on a cohort of melanoma patients followed in a tertiary care hospital. Fifty-eight (8.9%) patients developed MPM. Most patients were men (65.5%) and the median age at the time of diagnosis of the first melanoma was 71 years old. The median time of diagnosis of the second melanoma from the first melanoma was 10.9 months, and 77.6% of second melanomas were diagnosed within the first 5 years. In total, 29 (50%) and 28 (48.3%) first and second melanomas were located in the trunk, respectively. Concordance of anatomic site between primary and subsequent melanoma was found in 46.6% of the patients. Proportion of in situ melanomas was increasingly higher in subsequent melanomas (from 36.21% of first melanomas to 100% of fifth melanomas). An increasing rate of melanomas with histological regression was observed within subsequent melanomas (from 60.3% of first melanomas to 80% of third melanomas). Our results support the importance of careful long-term follow-up with total body examination in melanoma patients. |
| first_indexed | 2024-03-10T04:02:26Z |
| format | Article |
| id | doaj.art-6d0d590253b84092b203209f949a115c |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T04:02:26Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-6d0d590253b84092b203209f949a115c2023-11-23T08:31:08ZengMDPI AGJournal of Clinical Medicine2077-03832022-04-01119235510.3390/jcm11092355Multiple Primary Melanomas: Retrospective Review in a Tertiary Care HospitalRodolfo David Palacios-Diaz0Blanca de Unamuno-Bustos1Carlos Abril-Pérez2Mónica Pozuelo-Ruiz3Javier Sánchez-Arraez4Ignacio Torres-Navarro5Rafael Botella-Estrada6Department of Dermatology, Hospital Universitari i Politècnic La Fe, 46026 Valencia, SpainDepartment of Dermatology, Hospital Universitari i Politècnic La Fe, 46026 Valencia, SpainDepartment of Dermatology, Hospital Universitari i Politècnic La Fe, 46026 Valencia, SpainDepartment of Dermatology, Hospital Universitari i Politècnic La Fe, 46026 Valencia, SpainDepartment of Dermatology, Hospital Universitari i Politècnic La Fe, 46026 Valencia, SpainDepartment of Dermatology, Hospital Universitari i Politècnic La Fe, 46026 Valencia, SpainDepartment of Dermatology, Hospital Universitari i Politècnic La Fe, 46026 Valencia, SpainMultiple primary melanomas (MPM) refer to the occurrence of more than one synchronous or metachronous melanoma in the same individual. The aim of this study was to identify the frequency of MPM and describe the clinical and histopathologic characteristics of patients with MPM. An observational single-center retrospective study was designed based on a cohort of melanoma patients followed in a tertiary care hospital. Fifty-eight (8.9%) patients developed MPM. Most patients were men (65.5%) and the median age at the time of diagnosis of the first melanoma was 71 years old. The median time of diagnosis of the second melanoma from the first melanoma was 10.9 months, and 77.6% of second melanomas were diagnosed within the first 5 years. In total, 29 (50%) and 28 (48.3%) first and second melanomas were located in the trunk, respectively. Concordance of anatomic site between primary and subsequent melanoma was found in 46.6% of the patients. Proportion of in situ melanomas was increasingly higher in subsequent melanomas (from 36.21% of first melanomas to 100% of fifth melanomas). An increasing rate of melanomas with histological regression was observed within subsequent melanomas (from 60.3% of first melanomas to 80% of third melanomas). Our results support the importance of careful long-term follow-up with total body examination in melanoma patients.https://www.mdpi.com/2077-0383/11/9/2355melanomamultiple primary melanomafrequencyregressionfollow-up |
| spellingShingle | Rodolfo David Palacios-Diaz Blanca de Unamuno-Bustos Carlos Abril-Pérez Mónica Pozuelo-Ruiz Javier Sánchez-Arraez Ignacio Torres-Navarro Rafael Botella-Estrada Multiple Primary Melanomas: Retrospective Review in a Tertiary Care Hospital Journal of Clinical Medicine melanoma multiple primary melanoma frequency regression follow-up |
| title | Multiple Primary Melanomas: Retrospective Review in a Tertiary Care Hospital |
| title_full | Multiple Primary Melanomas: Retrospective Review in a Tertiary Care Hospital |
| title_fullStr | Multiple Primary Melanomas: Retrospective Review in a Tertiary Care Hospital |
| title_full_unstemmed | Multiple Primary Melanomas: Retrospective Review in a Tertiary Care Hospital |
| title_short | Multiple Primary Melanomas: Retrospective Review in a Tertiary Care Hospital |
| title_sort | multiple primary melanomas retrospective review in a tertiary care hospital |
| topic | melanoma multiple primary melanoma frequency regression follow-up |
| url | https://www.mdpi.com/2077-0383/11/9/2355 |
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