First Detection of Bat Astroviruses (BtAstVs) among Bats in Poland: The Genetic BtAstVs Diversity Reveals Multiple Co-Infection of Bats with Different Strains
Background: Astroviruses (AstVs) are common pathogens of a wide range of animal hosts, including mammals and avians, causing gastrointestinal diseases, mainly gastroenteritis and diarrhea. They prompt a significant health problem in newborns and young children and economic losses in the poultry sect...
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| Format: | Article |
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MDPI AG
2021-01-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/2/158 |
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| author | Anna Orłowska Marcin Smreczak Patrycja Potyrało Arkadiusz Bomba Paweł Trębas Jerzy Rola |
| author_facet | Anna Orłowska Marcin Smreczak Patrycja Potyrało Arkadiusz Bomba Paweł Trębas Jerzy Rola |
| author_sort | Anna Orłowska |
| collection | DOAJ |
| description | Background: Astroviruses (AstVs) are common pathogens of a wide range of animal hosts, including mammals and avians, causing gastrointestinal diseases, mainly gastroenteritis and diarrhea. They prompt a significant health problem in newborns and young children and economic losses in the poultry sector and mink farms. Recent studies revealed a growing number of bat species carrying astroviruses with a noticeable prevalence and diversity. Here, we demonstrate the first detection of bat astroviruses (BtAstVs) circulating in the population of insectivorous bats in the territory of Poland. Results: Genetically diverse BtAstVs (n = 18) were found with a varying degree of bat species specificity in five out of 15 bat species in Poland previously recognized as BtAstV hosts. Astroviral RNA was found in 12 out of 98 (12.2%, 95% CI 7.1–20.2) bat intestines, six bat kidneys (6.1%, 95% CI 2.8–12.7) and two bat livers (2.0%, 95% CI 0.4–7.1). Deep sequencing of the astroviral RNA-dependent RNA polymerase (RdRp) region revealed co-infections in five single bat individuals with highly distinct astrovirus strains. Conclusions: The detection of highly distinct bat astroviruses in Polish bats favors virus recombination and the generation of novel divergent AstVs and creates a potential risk of virus transmission to domestic animals and humans in the country. These findings provide a new insight into molecular epidemiology, prevalence of astroviruses in European bat populations and the risk of interspecies transmission to other animals including humans. |
| first_indexed | 2024-03-09T03:55:36Z |
| format | Article |
| id | doaj.art-6d0d62cab5a04dbb8c75c84784a897e1 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T03:55:36Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-6d0d62cab5a04dbb8c75c84784a897e12023-12-03T14:21:29ZengMDPI AGViruses1999-49152021-01-0113215810.3390/v13020158First Detection of Bat Astroviruses (BtAstVs) among Bats in Poland: The Genetic BtAstVs Diversity Reveals Multiple Co-Infection of Bats with Different StrainsAnna Orłowska0Marcin Smreczak1Patrycja Potyrało2Arkadiusz Bomba3Paweł Trębas4Jerzy Rola5Department of Virology, National Veterinary Research Institute, Al. Partyzantów 57, 24-100 Puławy, PolandDepartment of Virology, National Veterinary Research Institute, Al. Partyzantów 57, 24-100 Puławy, PolandDepartment of Virology, National Veterinary Research Institute, Al. Partyzantów 57, 24-100 Puławy, PolandDepartment of Omics Analyses, National Veterinary Research Institute, Al. Partyzantów 57, 24-100 Puławy, PolandDepartment of Virology, National Veterinary Research Institute, Al. Partyzantów 57, 24-100 Puławy, PolandDepartment of Virology, National Veterinary Research Institute, Al. Partyzantów 57, 24-100 Puławy, PolandBackground: Astroviruses (AstVs) are common pathogens of a wide range of animal hosts, including mammals and avians, causing gastrointestinal diseases, mainly gastroenteritis and diarrhea. They prompt a significant health problem in newborns and young children and economic losses in the poultry sector and mink farms. Recent studies revealed a growing number of bat species carrying astroviruses with a noticeable prevalence and diversity. Here, we demonstrate the first detection of bat astroviruses (BtAstVs) circulating in the population of insectivorous bats in the territory of Poland. Results: Genetically diverse BtAstVs (n = 18) were found with a varying degree of bat species specificity in five out of 15 bat species in Poland previously recognized as BtAstV hosts. Astroviral RNA was found in 12 out of 98 (12.2%, 95% CI 7.1–20.2) bat intestines, six bat kidneys (6.1%, 95% CI 2.8–12.7) and two bat livers (2.0%, 95% CI 0.4–7.1). Deep sequencing of the astroviral RNA-dependent RNA polymerase (RdRp) region revealed co-infections in five single bat individuals with highly distinct astrovirus strains. Conclusions: The detection of highly distinct bat astroviruses in Polish bats favors virus recombination and the generation of novel divergent AstVs and creates a potential risk of virus transmission to domestic animals and humans in the country. These findings provide a new insight into molecular epidemiology, prevalence of astroviruses in European bat populations and the risk of interspecies transmission to other animals including humans.https://www.mdpi.com/1999-4915/13/2/158astrovirusesbatsprevalencePolandphylogenetics |
| spellingShingle | Anna Orłowska Marcin Smreczak Patrycja Potyrało Arkadiusz Bomba Paweł Trębas Jerzy Rola First Detection of Bat Astroviruses (BtAstVs) among Bats in Poland: The Genetic BtAstVs Diversity Reveals Multiple Co-Infection of Bats with Different Strains Viruses astroviruses bats prevalence Poland phylogenetics |
| title | First Detection of Bat Astroviruses (BtAstVs) among Bats in Poland: The Genetic BtAstVs Diversity Reveals Multiple Co-Infection of Bats with Different Strains |
| title_full | First Detection of Bat Astroviruses (BtAstVs) among Bats in Poland: The Genetic BtAstVs Diversity Reveals Multiple Co-Infection of Bats with Different Strains |
| title_fullStr | First Detection of Bat Astroviruses (BtAstVs) among Bats in Poland: The Genetic BtAstVs Diversity Reveals Multiple Co-Infection of Bats with Different Strains |
| title_full_unstemmed | First Detection of Bat Astroviruses (BtAstVs) among Bats in Poland: The Genetic BtAstVs Diversity Reveals Multiple Co-Infection of Bats with Different Strains |
| title_short | First Detection of Bat Astroviruses (BtAstVs) among Bats in Poland: The Genetic BtAstVs Diversity Reveals Multiple Co-Infection of Bats with Different Strains |
| title_sort | first detection of bat astroviruses btastvs among bats in poland the genetic btastvs diversity reveals multiple co infection of bats with different strains |
| topic | astroviruses bats prevalence Poland phylogenetics |
| url | https://www.mdpi.com/1999-4915/13/2/158 |
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