Deciphering the Action of Perfluorohexyloctane Eye Drops to Reduce Ocular Discomfort and Pain
Perfluorohexyloctane (F6H8) eyedrops have been recently introduced in Europe as a product to treat dry eye disease, based on its ability to reduce tear film instability in Meibomian gland dysfunction and evaporative dry eye disease, although its mechanism of action is still unknown. In the present p...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-10-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.709712/full |
| _version_ | 1818403823284125696 |
|---|---|
| author | Miguel Delicado-Miralles Enrique Velasco Enrique Velasco Ariadna Díaz-Tahoces Ariadna Díaz-Tahoces Juana Gallar Juana Gallar Juana Gallar M. Carmen Acosta M. Carmen Acosta Adolfo Aracil-Marco |
| author_facet | Miguel Delicado-Miralles Enrique Velasco Enrique Velasco Ariadna Díaz-Tahoces Ariadna Díaz-Tahoces Juana Gallar Juana Gallar Juana Gallar M. Carmen Acosta M. Carmen Acosta Adolfo Aracil-Marco |
| author_sort | Miguel Delicado-Miralles |
| collection | DOAJ |
| description | Perfluorohexyloctane (F6H8) eyedrops have been recently introduced in Europe as a product to treat dry eye disease, based on its ability to reduce tear film instability in Meibomian gland dysfunction and evaporative dry eye disease, although its mechanism of action is still unknown. In the present pilot study, we evaluated the effects of the ocular instillation of a single drop of commercial F6H8 eyedrops in 20 healthy humans (9 women/11 men), measuring: (a) Corneal surface temperature (CST) from infrared video images; (b) tear volume using phenol red threads; (c) blinking frequency; and (d) ocular surface sensations (cold, dryness, pricking, foreign body, burning, itching, gritty, eye fatigue, watering eyes, and light-evoked discomfort sensations; scored using 10 cm Visual Analog Scales), before and 5–60 min after F6H8 or saline treatment. CST decreased and tearing and blinking frequency increased significantly after F6H8 but not after saline solution. When applied unilaterally, CST decreased only in the F6H8-treated eye. No sensations were evoked after F6H8 or saline. The corneal surface temperature reduction produced by topical F6H8 does not evoke conscious ocular sensations but is sufficient to increase the activity of corneal cold thermoreceptors, leading to an increased reflex lacrimation and blinking that may relieve dry eye condition thus reducing ocular discomfort and pain. |
| first_indexed | 2024-12-14T08:30:23Z |
| format | Article |
| id | doaj.art-6d0d6518ecfe48a290209ca89546ab25 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-14T08:30:23Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-6d0d6518ecfe48a290209ca89546ab252022-12-21T23:09:32ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-10-01810.3389/fmed.2021.709712709712Deciphering the Action of Perfluorohexyloctane Eye Drops to Reduce Ocular Discomfort and PainMiguel Delicado-Miralles0Enrique Velasco1Enrique Velasco2Ariadna Díaz-Tahoces3Ariadna Díaz-Tahoces4Juana Gallar5Juana Gallar6Juana Gallar7M. Carmen Acosta8M. Carmen Acosta9Adolfo Aracil-Marco10Cellular and Systems Neurobiology Unit, Instituto de Neurociencias, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas, San Juan de Alicante, SpainCellular and Systems Neurobiology Unit, Instituto de Neurociencias, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas, San Juan de Alicante, SpainThe European University of Brain and Technology-NeurotechEU, San Juan de Alicante, SpainCellular and Systems Neurobiology Unit, Instituto de Neurociencias, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas, San Juan de Alicante, SpainInstituto de Investigación Sanitaria y Biomédica de Alicante, San Juan de Alicante, SpainCellular and Systems Neurobiology Unit, Instituto de Neurociencias, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas, San Juan de Alicante, SpainThe European University of Brain and Technology-NeurotechEU, San Juan de Alicante, SpainInstituto de Investigación Sanitaria y Biomédica de Alicante, San Juan de Alicante, SpainCellular and Systems Neurobiology Unit, Instituto de Neurociencias, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas, San Juan de Alicante, SpainThe European University of Brain and Technology-NeurotechEU, San Juan de Alicante, SpainCellular and Systems Neurobiology Unit, Instituto de Neurociencias, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas, San Juan de Alicante, SpainPerfluorohexyloctane (F6H8) eyedrops have been recently introduced in Europe as a product to treat dry eye disease, based on its ability to reduce tear film instability in Meibomian gland dysfunction and evaporative dry eye disease, although its mechanism of action is still unknown. In the present pilot study, we evaluated the effects of the ocular instillation of a single drop of commercial F6H8 eyedrops in 20 healthy humans (9 women/11 men), measuring: (a) Corneal surface temperature (CST) from infrared video images; (b) tear volume using phenol red threads; (c) blinking frequency; and (d) ocular surface sensations (cold, dryness, pricking, foreign body, burning, itching, gritty, eye fatigue, watering eyes, and light-evoked discomfort sensations; scored using 10 cm Visual Analog Scales), before and 5–60 min after F6H8 or saline treatment. CST decreased and tearing and blinking frequency increased significantly after F6H8 but not after saline solution. When applied unilaterally, CST decreased only in the F6H8-treated eye. No sensations were evoked after F6H8 or saline. The corneal surface temperature reduction produced by topical F6H8 does not evoke conscious ocular sensations but is sufficient to increase the activity of corneal cold thermoreceptors, leading to an increased reflex lacrimation and blinking that may relieve dry eye condition thus reducing ocular discomfort and pain.https://www.frontiersin.org/articles/10.3389/fmed.2021.709712/fullocular discomfortocular paindry eyeperfluorohexyloctaneblinkingtearing |
| spellingShingle | Miguel Delicado-Miralles Enrique Velasco Enrique Velasco Ariadna Díaz-Tahoces Ariadna Díaz-Tahoces Juana Gallar Juana Gallar Juana Gallar M. Carmen Acosta M. Carmen Acosta Adolfo Aracil-Marco Deciphering the Action of Perfluorohexyloctane Eye Drops to Reduce Ocular Discomfort and Pain Frontiers in Medicine ocular discomfort ocular pain dry eye perfluorohexyloctane blinking tearing |
| title | Deciphering the Action of Perfluorohexyloctane Eye Drops to Reduce Ocular Discomfort and Pain |
| title_full | Deciphering the Action of Perfluorohexyloctane Eye Drops to Reduce Ocular Discomfort and Pain |
| title_fullStr | Deciphering the Action of Perfluorohexyloctane Eye Drops to Reduce Ocular Discomfort and Pain |
| title_full_unstemmed | Deciphering the Action of Perfluorohexyloctane Eye Drops to Reduce Ocular Discomfort and Pain |
| title_short | Deciphering the Action of Perfluorohexyloctane Eye Drops to Reduce Ocular Discomfort and Pain |
| title_sort | deciphering the action of perfluorohexyloctane eye drops to reduce ocular discomfort and pain |
| topic | ocular discomfort ocular pain dry eye perfluorohexyloctane blinking tearing |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.709712/full |
| work_keys_str_mv | AT migueldelicadomiralles decipheringtheactionofperfluorohexyloctaneeyedropstoreduceoculardiscomfortandpain AT enriquevelasco decipheringtheactionofperfluorohexyloctaneeyedropstoreduceoculardiscomfortandpain AT enriquevelasco decipheringtheactionofperfluorohexyloctaneeyedropstoreduceoculardiscomfortandpain AT ariadnadiaztahoces decipheringtheactionofperfluorohexyloctaneeyedropstoreduceoculardiscomfortandpain AT ariadnadiaztahoces decipheringtheactionofperfluorohexyloctaneeyedropstoreduceoculardiscomfortandpain AT juanagallar decipheringtheactionofperfluorohexyloctaneeyedropstoreduceoculardiscomfortandpain AT juanagallar decipheringtheactionofperfluorohexyloctaneeyedropstoreduceoculardiscomfortandpain AT juanagallar decipheringtheactionofperfluorohexyloctaneeyedropstoreduceoculardiscomfortandpain AT mcarmenacosta decipheringtheactionofperfluorohexyloctaneeyedropstoreduceoculardiscomfortandpain AT mcarmenacosta decipheringtheactionofperfluorohexyloctaneeyedropstoreduceoculardiscomfortandpain AT adolfoaracilmarco decipheringtheactionofperfluorohexyloctaneeyedropstoreduceoculardiscomfortandpain |