Osteopontin - The stirring multifunctional regulatory factor in multisystem aging
Osteopontin (OPN) is a multifunctional noncollagenous matrix phosphoprotein that is expressed both intracellularly and extracellularly in various tissues. As a growth regulatory protein and proinflammatory immunochemokine, OPN is involved in the pathological processes of many diseases. Recent studie...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1014853/full |
| _version_ | 1797979445475147776 |
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| author | Yuxiang Du Liwei Mao Zhikun Wang Kai Yan Lingli Zhang Jun Zou |
| author_facet | Yuxiang Du Liwei Mao Zhikun Wang Kai Yan Lingli Zhang Jun Zou |
| author_sort | Yuxiang Du |
| collection | DOAJ |
| description | Osteopontin (OPN) is a multifunctional noncollagenous matrix phosphoprotein that is expressed both intracellularly and extracellularly in various tissues. As a growth regulatory protein and proinflammatory immunochemokine, OPN is involved in the pathological processes of many diseases. Recent studies have found that OPN is widely involved in the aging processes of multiple organs and tissues, such as T-cell senescence, atherosclerosis, skeletal muscle regeneration, osteoporosis, neurodegenerative changes, hematopoietic stem cell reconstruction, and retinal aging. However, the regulatory roles and mechanisms of OPN in the aging process of different tissues are not uniform, and OPN even has diverse roles in different developmental stages of the same tissue, generating uncertainty for the future study and utilization of OPN. In this review, we will summarize the regulatory role and molecular mechanism of OPN in different tissues and cells, such as the musculoskeletal system, central nervous system, cardiovascular system, liver, and eye, during senescence. We believe that a better understanding of the mechanism of OPN in the aging process will help us develop targeted and comprehensive therapeutic strategies to fight the spread of age-related diseases. |
| first_indexed | 2024-04-11T05:40:05Z |
| format | Article |
| id | doaj.art-6d0dfccb3dc64cbc95aa8344091ee16c |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T05:40:05Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-6d0dfccb3dc64cbc95aa8344091ee16c2022-12-22T06:40:31ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-12-011310.3389/fendo.2022.10148531014853Osteopontin - The stirring multifunctional regulatory factor in multisystem agingYuxiang DuLiwei MaoZhikun WangKai YanLingli ZhangJun ZouOsteopontin (OPN) is a multifunctional noncollagenous matrix phosphoprotein that is expressed both intracellularly and extracellularly in various tissues. As a growth regulatory protein and proinflammatory immunochemokine, OPN is involved in the pathological processes of many diseases. Recent studies have found that OPN is widely involved in the aging processes of multiple organs and tissues, such as T-cell senescence, atherosclerosis, skeletal muscle regeneration, osteoporosis, neurodegenerative changes, hematopoietic stem cell reconstruction, and retinal aging. However, the regulatory roles and mechanisms of OPN in the aging process of different tissues are not uniform, and OPN even has diverse roles in different developmental stages of the same tissue, generating uncertainty for the future study and utilization of OPN. In this review, we will summarize the regulatory role and molecular mechanism of OPN in different tissues and cells, such as the musculoskeletal system, central nervous system, cardiovascular system, liver, and eye, during senescence. We believe that a better understanding of the mechanism of OPN in the aging process will help us develop targeted and comprehensive therapeutic strategies to fight the spread of age-related diseases.https://www.frontiersin.org/articles/10.3389/fendo.2022.1014853/fullosteopontinmulti-tissue regulationcell senescenceosteoporosisneurodegeneration |
| spellingShingle | Yuxiang Du Liwei Mao Zhikun Wang Kai Yan Lingli Zhang Jun Zou Osteopontin - The stirring multifunctional regulatory factor in multisystem aging Frontiers in Endocrinology osteopontin multi-tissue regulation cell senescence osteoporosis neurodegeneration |
| title | Osteopontin - The stirring multifunctional regulatory factor in multisystem aging |
| title_full | Osteopontin - The stirring multifunctional regulatory factor in multisystem aging |
| title_fullStr | Osteopontin - The stirring multifunctional regulatory factor in multisystem aging |
| title_full_unstemmed | Osteopontin - The stirring multifunctional regulatory factor in multisystem aging |
| title_short | Osteopontin - The stirring multifunctional regulatory factor in multisystem aging |
| title_sort | osteopontin the stirring multifunctional regulatory factor in multisystem aging |
| topic | osteopontin multi-tissue regulation cell senescence osteoporosis neurodegeneration |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1014853/full |
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