Sex-inducing effects toward planarians widely present among parasitic flatworms
Summary: Various parasitic flatworms infect vertebrates for sexual reproduction, often causing devastating diseases in their hosts. Consequently, flatworms are of great socioeconomic and biomedical importance. Although the cessation of parasitic flatworm sexual reproduction is a major target of anti...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222020491 |
| _version_ | 1828057133164265472 |
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| author | Kiyono Sekii Soichiro Miyashita Kentaro Yamaguchi Ikuma Saito Yuria Saito Sayaka Manta Masaki Ishikawa Miyu Narita Taro Watanabe Riku Ito Mizuki Taguchi Ryohei Furukawa Aoi Ikeuchi Kayoko Matsuo Goro Kurita Takashi Kumagai Sho Shirakashi Kazuo Ogawa Kimitoshi Sakamoto Ryo Koyanagi Noriyuki Satoh Mizuki Sasaki Takanobu Maezawa Madoka Ichikawa-Seki Kazuya Kobayashi |
| author_facet | Kiyono Sekii Soichiro Miyashita Kentaro Yamaguchi Ikuma Saito Yuria Saito Sayaka Manta Masaki Ishikawa Miyu Narita Taro Watanabe Riku Ito Mizuki Taguchi Ryohei Furukawa Aoi Ikeuchi Kayoko Matsuo Goro Kurita Takashi Kumagai Sho Shirakashi Kazuo Ogawa Kimitoshi Sakamoto Ryo Koyanagi Noriyuki Satoh Mizuki Sasaki Takanobu Maezawa Madoka Ichikawa-Seki Kazuya Kobayashi |
| author_sort | Kiyono Sekii |
| collection | DOAJ |
| description | Summary: Various parasitic flatworms infect vertebrates for sexual reproduction, often causing devastating diseases in their hosts. Consequently, flatworms are of great socioeconomic and biomedical importance. Although the cessation of parasitic flatworm sexual reproduction is a major target of anti-parasitic drug design, little is known regarding bioactive compounds controlling flatworm sexual maturation. Using the planarian Dugesia ryukyuensis, we observed that sex-inducing substances found in planarians are also widespread in parasitic flatworms, such as monogeneans and flukes (but not in tapeworms). Reverse-phase HPLC analysis revealed the sex-inducing substance(s) eluting around the tryptophan retention time in the fluke Calicophoron calicophorum, consistent with previous studies on the planarian Bipalium nobile, suggesting that the substance(s) is likely conserved among flatworms. Moreover, six of the 18 ovary-inducing substances identified via transcriptome and metabolome analyses are involved in purine metabolism. Our findings provide a basis for understanding and modifying the life cycles of various parasitic flatworms. |
| first_indexed | 2024-04-10T21:06:30Z |
| format | Article |
| id | doaj.art-6d1100a7c27642c6a4fdca07f15e0405 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-10T21:06:30Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-6d1100a7c27642c6a4fdca07f15e04052023-01-22T04:40:54ZengElsevieriScience2589-00422023-01-01261105776Sex-inducing effects toward planarians widely present among parasitic flatwormsKiyono Sekii0Soichiro Miyashita1Kentaro Yamaguchi2Ikuma Saito3Yuria Saito4Sayaka Manta5Masaki Ishikawa6Miyu Narita7Taro Watanabe8Riku Ito9Mizuki Taguchi10Ryohei Furukawa11Aoi Ikeuchi12Kayoko Matsuo13Goro Kurita14Takashi Kumagai15Sho Shirakashi16Kazuo Ogawa17Kimitoshi Sakamoto18Ryo Koyanagi19Noriyuki Satoh20Mizuki Sasaki21Takanobu Maezawa22Madoka Ichikawa-Seki23Kazuya Kobayashi24Department of Biology, Faculty of Agriculture and Life Science, Hirosaki University, Bunkyo-cho 3, Hirosaki, Aomori 036-8561, Japan; Corresponding authorDepartment of Biology, Faculty of Agriculture and Life Science, Hirosaki University, Bunkyo-cho 3, Hirosaki, Aomori 036-8561, JapanDepartment of Biology, Faculty of Agriculture and Life Science, Hirosaki University, Bunkyo-cho 3, Hirosaki, Aomori 036-8561, JapanDepartment of Biology, Faculty of Agriculture and Life Science, Hirosaki University, Bunkyo-cho 3, Hirosaki, Aomori 036-8561, JapanDepartment of Biology, Faculty of Agriculture and Life Science, Hirosaki University, Bunkyo-cho 3, Hirosaki, Aomori 036-8561, JapanDepartment of Biology, Faculty of Agriculture and Life Science, Hirosaki University, Bunkyo-cho 3, Hirosaki, Aomori 036-8561, JapanDepartment of Biology, Faculty of Agriculture and Life Science, Hirosaki University, Bunkyo-cho 3, Hirosaki, Aomori 036-8561, JapanDepartment of Biology, Faculty of Agriculture and Life Science, Hirosaki University, Bunkyo-cho 3, Hirosaki, Aomori 036-8561, JapanDepartment of Biology, Faculty of Agriculture and Life Science, Hirosaki University, Bunkyo-cho 3, Hirosaki, Aomori 036-8561, JapanDepartment of Biology, Faculty of Agriculture and Life Science, Hirosaki University, Bunkyo-cho 3, Hirosaki, Aomori 036-8561, JapanDepartment of Biology, Research and Education Center for Natural Sciences, Keio University, 4-1-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8521, JapanDepartment of Biology, Research and Education Center for Natural Sciences, Keio University, 4-1-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8521, JapanLaboratory of Veterinary Parasitology, Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, JapanFaculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, JapanKurita Animal Hospital, 139-1 Koga, Koga, Ibaraki 306-0016, JapanSection of Environmental Parasitology, Graduate School, Tokyo Medical & Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, JapanAquaculture Research Institute, Kindai University, Shirahama 3153, Nishimuro-gun, Wakayama 649-2211, JapanMeguro Parasitological Museum, 4-1-1 Shimo-Meguro, Meguro, Tokyo 153-0064, JapanDepartment of Biology, Faculty of Agriculture and Life Science, Hirosaki University, Bunkyo-cho 3, Hirosaki, Aomori 036-8561, JapanMarine Genomics Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa 904-0495, JapanMarine Genomics Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa 904-0495, JapanDepartment of Parasitology, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, JapanDepartment of Integrated Science and Technology, National Institute of Technology, Tsuyama College, 624-1 Numa, Tsuyama, Okayama 708–8509, JapanLaboratory of Veterinary Parasitology, Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan; Corresponding authorDepartment of Biology, Faculty of Agriculture and Life Science, Hirosaki University, Bunkyo-cho 3, Hirosaki, Aomori 036-8561, Japan; Corresponding authorSummary: Various parasitic flatworms infect vertebrates for sexual reproduction, often causing devastating diseases in their hosts. Consequently, flatworms are of great socioeconomic and biomedical importance. Although the cessation of parasitic flatworm sexual reproduction is a major target of anti-parasitic drug design, little is known regarding bioactive compounds controlling flatworm sexual maturation. Using the planarian Dugesia ryukyuensis, we observed that sex-inducing substances found in planarians are also widespread in parasitic flatworms, such as monogeneans and flukes (but not in tapeworms). Reverse-phase HPLC analysis revealed the sex-inducing substance(s) eluting around the tryptophan retention time in the fluke Calicophoron calicophorum, consistent with previous studies on the planarian Bipalium nobile, suggesting that the substance(s) is likely conserved among flatworms. Moreover, six of the 18 ovary-inducing substances identified via transcriptome and metabolome analyses are involved in purine metabolism. Our findings provide a basis for understanding and modifying the life cycles of various parasitic flatworms.http://www.sciencedirect.com/science/article/pii/S2589004222020491ParasitologyDevelopmental genetics |
| spellingShingle | Kiyono Sekii Soichiro Miyashita Kentaro Yamaguchi Ikuma Saito Yuria Saito Sayaka Manta Masaki Ishikawa Miyu Narita Taro Watanabe Riku Ito Mizuki Taguchi Ryohei Furukawa Aoi Ikeuchi Kayoko Matsuo Goro Kurita Takashi Kumagai Sho Shirakashi Kazuo Ogawa Kimitoshi Sakamoto Ryo Koyanagi Noriyuki Satoh Mizuki Sasaki Takanobu Maezawa Madoka Ichikawa-Seki Kazuya Kobayashi Sex-inducing effects toward planarians widely present among parasitic flatworms iScience Parasitology Developmental genetics |
| title | Sex-inducing effects toward planarians widely present among parasitic flatworms |
| title_full | Sex-inducing effects toward planarians widely present among parasitic flatworms |
| title_fullStr | Sex-inducing effects toward planarians widely present among parasitic flatworms |
| title_full_unstemmed | Sex-inducing effects toward planarians widely present among parasitic flatworms |
| title_short | Sex-inducing effects toward planarians widely present among parasitic flatworms |
| title_sort | sex inducing effects toward planarians widely present among parasitic flatworms |
| topic | Parasitology Developmental genetics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222020491 |
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