The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets

The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets

The hexameric AAA ATPase Vps4 drives membrane fission by remodeling and disassembling ESCRT-III filaments. Building upon our earlier 4.3 Å resolution cryo-EM structure (Monroe et al., 2017), we now report a 3.2 Å structure of Vps4 bound to an ESCRT-III peptide substrate. The new structure reveals th...

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Bibliographic Details
Main Authors: Han Han, Nicole Monroe, Wesley I Sundquist, Peter S Shen, Christopher P Hill
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-11-01
Series:eLife
Subjects:
ESCRT pathway
AAA ATPase
cryo-EM
structure
membrane fission
Online Access:https://elifesciences.org/articles/31324

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