Ceramide Synthase Schlank Is a Transcriptional Regulator Adapting Gene Expression to Energy Requirements

Ceramide Synthase Schlank Is a Transcriptional Regulator Adapting Gene Expression to Energy Requirements

Maintenance of metabolic homeostasis requires adaption of gene regulation to the cellular energy state via transcriptional regulators. Here, we identify a role of ceramide synthase (CerS) Schlank, a multiple transmembrane protein containing a catalytic lag1p motif and a homeodomain, which is poorly...

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Bibliographic Details
Main Authors: Mariangela Sociale, Anna-Lena Wulf, Bernadette Breiden, Kathrin Klee, Melanie Thielisch, Franka Eckardt, Julia Sellin, Margret H. Bülow, Sinah Löbbert, Nadine Weinstock, André Voelzmann, Joachim Schultze, Konrad Sandhoff, Reinhard Bauer
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cell Reports
Subjects:
ceramide synthase
homeodomain
transcription factors
energy homeostasis
lipid metabolism
genomic engineering
peroxisome
lipid sensing
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717319277

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