Recent-Onset Melanoma and the Implications of the Excessive Use of Tanning Devices—Case Report and Review of the Literature
<i>Introduction</i>: Melanoma, a malignant tumor arising from uncontrolled melanocytic proliferation, commonly found in the skin but capable of affecting extracutaneous sites, ranks fifth among diagnosed oncological entities and is a significant cause of cancer deaths, constituting over...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/60/1/187 |
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| author | Luana-Andreea Nurla Gina Wafi Raluca Tatar Alexandra Maria Dorobanțu Mădălina Chivu Liliana Gabriela Popa Călin Giurcăneanu Olguța Anca Orzan |
| author_facet | Luana-Andreea Nurla Gina Wafi Raluca Tatar Alexandra Maria Dorobanțu Mădălina Chivu Liliana Gabriela Popa Călin Giurcăneanu Olguța Anca Orzan |
| author_sort | Luana-Andreea Nurla |
| collection | DOAJ |
| description | <i>Introduction</i>: Melanoma, a malignant tumor arising from uncontrolled melanocytic proliferation, commonly found in the skin but capable of affecting extracutaneous sites, ranks fifth among diagnosed oncological entities and is a significant cause of cancer deaths, constituting over 80% of skin cancer mortality. Genetic factors and ultraviolet radiation (UVR) exposure, from both natural and artificial sources, are the primary risk factors. <i>Case Presentation</i>: We reported the case of a 25-year-old female with numerous pigmented nevi and notable changes attributed to extensive indoor tanning sessions. Dermatological examinations and dermoscopic evaluations revealed atypical features in two pigmented nevi, leading to surgical excision. Histopathological and immunohistochemical analyses confirmed a compound nevus in one lesion and superficial spreading melanoma in the other, emphasizing the importance of vigilant follow-up and the correct use of immunohistochemistry. <i>Discussion</i>: Indoor tanning significantly elevates the cutaneous melanoma risk, with initiation before age 35 amplifying the risk by up to 75%, especially in young women. The risk escalates with cumulative sessions, particularly exceeding 480, and individuals undergoing over 30 sessions face a 32% higher risk. UVR induces DNA damage, genetic mutations, and immunosuppression, contributing to oncogenesis. Genetic factors, like the PTCHD2 gene, may influence the tanning dependency. Legislation targeting minors has been enacted globally but only with partial efficacy. Tanning accelerators, though associated with minor side effects, correlate with high-risk behaviors. The case underscores the urgency of addressing indoor tanning risks, emphasizing targeted awareness efforts and legislative improvements. <i>Conclusions</i>: In conclusion, the reported case highlights the increased risk of cutaneous melanoma linked to indoor tanning, particularly among young women and specific sociodemographic groups. Despite legislative measures, challenges persist, suggesting the potential efficacy of online campaigns involving relatable influencers to raise awareness and discourage artificial tanning. |
| first_indexed | 2024-03-08T10:41:17Z |
| format | Article |
| id | doaj.art-6d1499eb277b44babce98439a44880c3 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-08T10:41:17Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-6d1499eb277b44babce98439a44880c32024-01-26T17:35:52ZengMDPI AGMedicina1010-660X1648-91442024-01-0160118710.3390/medicina60010187Recent-Onset Melanoma and the Implications of the Excessive Use of Tanning Devices—Case Report and Review of the LiteratureLuana-Andreea Nurla0Gina Wafi1Raluca Tatar2Alexandra Maria Dorobanțu3Mădălina Chivu4Liliana Gabriela Popa5Călin Giurcăneanu6Olguța Anca Orzan7Faculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDermatovenerology Clinic, “Victor Babeș” Clinical Hospital for Infectious and Tropical Diseases, 030303 Bucharest, RomaniaDepartment of Plastic Reconstructive Surgery and Burns, “Grigore Alexandrescu” Clinical Emergency Hospital for Children, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaFaculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Pathology, “Elias” Emergency University Hospital, 011461 Bucharest, RomaniaFaculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, RomaniaFaculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, RomaniaFaculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania<i>Introduction</i>: Melanoma, a malignant tumor arising from uncontrolled melanocytic proliferation, commonly found in the skin but capable of affecting extracutaneous sites, ranks fifth among diagnosed oncological entities and is a significant cause of cancer deaths, constituting over 80% of skin cancer mortality. Genetic factors and ultraviolet radiation (UVR) exposure, from both natural and artificial sources, are the primary risk factors. <i>Case Presentation</i>: We reported the case of a 25-year-old female with numerous pigmented nevi and notable changes attributed to extensive indoor tanning sessions. Dermatological examinations and dermoscopic evaluations revealed atypical features in two pigmented nevi, leading to surgical excision. Histopathological and immunohistochemical analyses confirmed a compound nevus in one lesion and superficial spreading melanoma in the other, emphasizing the importance of vigilant follow-up and the correct use of immunohistochemistry. <i>Discussion</i>: Indoor tanning significantly elevates the cutaneous melanoma risk, with initiation before age 35 amplifying the risk by up to 75%, especially in young women. The risk escalates with cumulative sessions, particularly exceeding 480, and individuals undergoing over 30 sessions face a 32% higher risk. UVR induces DNA damage, genetic mutations, and immunosuppression, contributing to oncogenesis. Genetic factors, like the PTCHD2 gene, may influence the tanning dependency. Legislation targeting minors has been enacted globally but only with partial efficacy. Tanning accelerators, though associated with minor side effects, correlate with high-risk behaviors. The case underscores the urgency of addressing indoor tanning risks, emphasizing targeted awareness efforts and legislative improvements. <i>Conclusions</i>: In conclusion, the reported case highlights the increased risk of cutaneous melanoma linked to indoor tanning, particularly among young women and specific sociodemographic groups. Despite legislative measures, challenges persist, suggesting the potential efficacy of online campaigns involving relatable influencers to raise awareness and discourage artificial tanning.https://www.mdpi.com/1648-9144/60/1/187indoor tanningmelanomadysplastic neviultraviolet light exposurecase report |
| spellingShingle | Luana-Andreea Nurla Gina Wafi Raluca Tatar Alexandra Maria Dorobanțu Mădălina Chivu Liliana Gabriela Popa Călin Giurcăneanu Olguța Anca Orzan Recent-Onset Melanoma and the Implications of the Excessive Use of Tanning Devices—Case Report and Review of the Literature Medicina indoor tanning melanoma dysplastic nevi ultraviolet light exposure case report |
| title | Recent-Onset Melanoma and the Implications of the Excessive Use of Tanning Devices—Case Report and Review of the Literature |
| title_full | Recent-Onset Melanoma and the Implications of the Excessive Use of Tanning Devices—Case Report and Review of the Literature |
| title_fullStr | Recent-Onset Melanoma and the Implications of the Excessive Use of Tanning Devices—Case Report and Review of the Literature |
| title_full_unstemmed | Recent-Onset Melanoma and the Implications of the Excessive Use of Tanning Devices—Case Report and Review of the Literature |
| title_short | Recent-Onset Melanoma and the Implications of the Excessive Use of Tanning Devices—Case Report and Review of the Literature |
| title_sort | recent onset melanoma and the implications of the excessive use of tanning devices case report and review of the literature |
| topic | indoor tanning melanoma dysplastic nevi ultraviolet light exposure case report |
| url | https://www.mdpi.com/1648-9144/60/1/187 |
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