The HIF-1α as a Potent Inducer of the Hallmarks in Gastric Cancer
Hypoxia is the principal architect of the topographic heterogeneity in tumors. Hypoxia-inducible factor-1α (HIF-1α) reinforces all hallmarks of cancer and donates cancer cells with more aggressive characteristics at hypoxic niches. HIF-1α potently induces sustained growth factor signaling, angiogene...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/11/2711 |
| _version_ | 1797493913638928384 |
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| author | Cemre Ucaryilmaz Metin Gulnihal Ozcan |
| author_facet | Cemre Ucaryilmaz Metin Gulnihal Ozcan |
| author_sort | Cemre Ucaryilmaz Metin |
| collection | DOAJ |
| description | Hypoxia is the principal architect of the topographic heterogeneity in tumors. Hypoxia-inducible factor-1α (HIF-1α) reinforces all hallmarks of cancer and donates cancer cells with more aggressive characteristics at hypoxic niches. HIF-1α potently induces sustained growth factor signaling, angiogenesis, epithelial–mesenchymal transition, and replicative immortality. Hypoxia leads to the selection of cancer cells that evade growth suppressors or apoptotic triggers and deregulates cellular energetics. HIF-1α is also associated with genetic instability, tumor-promoting inflammation, and escape from immunity. Therefore, HIF-1α may be an important therapeutic target in cancer. Despite that, the drug market lacks safe and efficacious anti-HIF-1α molecules, raising the quest for fully unveiling the complex interactome of HIF-1α in cancer to discover more effective strategies. The knowledge gap is even wider in gastric cancer, where the number of studies on hypoxia is relatively low compared to other well-dissected cancers. A comprehensive review of the molecular mechanisms by which HIF-1α induces gastric cancer hallmarks could provide a broad perspective to the investigators and reveal missing links to explore in future studies. Thus, here we review the impact of HIF-1α on the cancer hallmarks with a specific focus on gastric cancer. |
| first_indexed | 2024-03-10T01:26:48Z |
| format | Article |
| id | doaj.art-6d1775cd697445d29b39887798339d86 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T01:26:48Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-6d1775cd697445d29b39887798339d862023-11-23T13:49:53ZengMDPI AGCancers2072-66942022-05-011411271110.3390/cancers14112711The HIF-1α as a Potent Inducer of the Hallmarks in Gastric CancerCemre Ucaryilmaz Metin0Gulnihal Ozcan1Graduate School of Health Sciences, Koç University, 34450 Istanbul, TurkeyDepartment of Medical Pharmacology, School of Medicine, Koç University, 34450 Istanbul, TurkeyHypoxia is the principal architect of the topographic heterogeneity in tumors. Hypoxia-inducible factor-1α (HIF-1α) reinforces all hallmarks of cancer and donates cancer cells with more aggressive characteristics at hypoxic niches. HIF-1α potently induces sustained growth factor signaling, angiogenesis, epithelial–mesenchymal transition, and replicative immortality. Hypoxia leads to the selection of cancer cells that evade growth suppressors or apoptotic triggers and deregulates cellular energetics. HIF-1α is also associated with genetic instability, tumor-promoting inflammation, and escape from immunity. Therefore, HIF-1α may be an important therapeutic target in cancer. Despite that, the drug market lacks safe and efficacious anti-HIF-1α molecules, raising the quest for fully unveiling the complex interactome of HIF-1α in cancer to discover more effective strategies. The knowledge gap is even wider in gastric cancer, where the number of studies on hypoxia is relatively low compared to other well-dissected cancers. A comprehensive review of the molecular mechanisms by which HIF-1α induces gastric cancer hallmarks could provide a broad perspective to the investigators and reveal missing links to explore in future studies. Thus, here we review the impact of HIF-1α on the cancer hallmarks with a specific focus on gastric cancer.https://www.mdpi.com/2072-6694/14/11/2711gastric cancerhypoxiahypoxia-inducible factor-1αhallmarks of cancer |
| spellingShingle | Cemre Ucaryilmaz Metin Gulnihal Ozcan The HIF-1α as a Potent Inducer of the Hallmarks in Gastric Cancer Cancers gastric cancer hypoxia hypoxia-inducible factor-1α hallmarks of cancer |
| title | The HIF-1α as a Potent Inducer of the Hallmarks in Gastric Cancer |
| title_full | The HIF-1α as a Potent Inducer of the Hallmarks in Gastric Cancer |
| title_fullStr | The HIF-1α as a Potent Inducer of the Hallmarks in Gastric Cancer |
| title_full_unstemmed | The HIF-1α as a Potent Inducer of the Hallmarks in Gastric Cancer |
| title_short | The HIF-1α as a Potent Inducer of the Hallmarks in Gastric Cancer |
| title_sort | hif 1α as a potent inducer of the hallmarks in gastric cancer |
| topic | gastric cancer hypoxia hypoxia-inducible factor-1α hallmarks of cancer |
| url | https://www.mdpi.com/2072-6694/14/11/2711 |
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