DNA polymerase delta interacting protein 3 facilitates the activation and maintenance of DNA damage checkpoint in response to replication stress

DNA polymerase delta interacting protein 3 facilitates the activation and maintenance of DNA damage checkpoint in response to replication stress

Abstract Background Replication stress response is crucial for the maintenance of a stable genome. POLDIP3 (DNA polymerase delta interacting protein 3) was initially identified as one of the DNA polymerase δ (Pol δ) interacting proteins almost 20 years ago. Using a variety of in vitro biochemical as...

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Bibliographic Details
Main Authors: Sufang Zhang, Ernest Y. C. Lee, Marietta Y. W. T. Lee, Dong Zhang
Format: Article
Language:English
Published: Wiley 2022-10-01
Series:Animal Models and Experimental Medicine
Subjects:
DNA damage checkpoint
DNA polymerase delta
POLDIP3
replication stress
Online Access:https://doi.org/10.1002/ame2.12274

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