Cardiac biomarkers in neonatology: BNP/NTproBNP, troponin I/T, CK-MB and myoglobin – a systematic review
Cardiac biomarkers play a central role in myocardial injury and heart failure in adult patients, but their clinical relevance in neonatology has not been clearly stablished. The aim of this systematic review was to evaluate the recent literature on B-type natriuretic peptide (BNP)/N-terminal-pro-BNP...
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| Format: | Article |
| Language: | English |
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Hygeia Press di Corridori Marinella
2017-08-01
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| Series: | Journal of Pediatric and Neonatal Individualized Medicine |
| Subjects: | |
| Online Access: | https://www.jpnim.com/index.php/jpnim/article/view/533 |
| _version_ | 1828761115632336896 |
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| author | Rita P. Teixeira Ana L. Neves Hercília Guimarães |
| author_facet | Rita P. Teixeira Ana L. Neves Hercília Guimarães |
| author_sort | Rita P. Teixeira |
| collection | DOAJ |
| description | Cardiac biomarkers play a central role in myocardial injury and heart failure in adult patients, but their clinical relevance in neonatology has not been clearly stablished. The aim of this systematic review was to evaluate the recent literature on B-type natriuretic peptide (BNP)/N-terminal-pro-BNP (NTproBNP), troponin I/T, Creatine Kinase-MB (CK-MB) and myoglobin and their relationship with different pathologies of the newborn.
A total of 67 articles were included to undergo data extraction, after a first text and abstract analysis and a second full-text analysis, using the PubMed database.
Evidence shows that cardiac biomarkers are a useful and fast diagnostic tool with great potential for becoming as important as clinical and echocardiographic findings in pathologies of the heart. BNP/NTproBNP and troponin I/T demonstrated to be the ones with greater value. BNP/NTproBNP is of particular significance in the diagnosis and management of patent ductus arteriosus, as it has a good correlation with diagnosis, treatment and prognosis. Troponin T may be a beneficial additional marker for this disease, correlating with ductal significance and treatment response. Moreover, BNP/NTproBNP can be used, with other clinical and laboratory findings, in the diagnosis and as a guide for treatment in pulmonary hypertension and in the diagnosis and management of cardiac sequela in bronchopulmonary dysplasia. Troponin I/T finds its clinical importance in perinatal asphyxia as a marker of myocardial injury and a reliable indicator of severity and mortality.
Further studies with larger cohort populations are needed for stablishing the cutoff values specific for each neonatal pathology allowing its early and proper management. |
| first_indexed | 2024-12-11T01:24:46Z |
| format | Article |
| id | doaj.art-6d1b58a632cf4b569cae769d482baecd |
| institution | Directory Open Access Journal |
| issn | 2281-0692 |
| language | English |
| last_indexed | 2024-12-11T01:24:46Z |
| publishDate | 2017-08-01 |
| publisher | Hygeia Press di Corridori Marinella |
| record_format | Article |
| series | Journal of Pediatric and Neonatal Individualized Medicine |
| spelling | doaj.art-6d1b58a632cf4b569cae769d482baecd2022-12-22T01:25:36ZengHygeia Press di Corridori MarinellaJournal of Pediatric and Neonatal Individualized Medicine2281-06922017-08-0162e060219e06021910.7363/060219445Cardiac biomarkers in neonatology: BNP/NTproBNP, troponin I/T, CK-MB and myoglobin – a systematic reviewRita P. Teixeira0Ana L. Neves1Hercília Guimarães2Department of Pediatrics, Faculty of Medicine, University of Porto, Porto, PortugalDepartment of Pediatrics, Faculty of Medicine, University of Porto, Porto, Portugal; Department of Pediatric Cardiology, São João Hospital, Porto, PortugalDepartment of Pediatrics, Faculty of Medicine, University of Porto, Porto, Portugal; Department of Neonatology, São João Hospital, Porto, PortugalCardiac biomarkers play a central role in myocardial injury and heart failure in adult patients, but their clinical relevance in neonatology has not been clearly stablished. The aim of this systematic review was to evaluate the recent literature on B-type natriuretic peptide (BNP)/N-terminal-pro-BNP (NTproBNP), troponin I/T, Creatine Kinase-MB (CK-MB) and myoglobin and their relationship with different pathologies of the newborn. A total of 67 articles were included to undergo data extraction, after a first text and abstract analysis and a second full-text analysis, using the PubMed database. Evidence shows that cardiac biomarkers are a useful and fast diagnostic tool with great potential for becoming as important as clinical and echocardiographic findings in pathologies of the heart. BNP/NTproBNP and troponin I/T demonstrated to be the ones with greater value. BNP/NTproBNP is of particular significance in the diagnosis and management of patent ductus arteriosus, as it has a good correlation with diagnosis, treatment and prognosis. Troponin T may be a beneficial additional marker for this disease, correlating with ductal significance and treatment response. Moreover, BNP/NTproBNP can be used, with other clinical and laboratory findings, in the diagnosis and as a guide for treatment in pulmonary hypertension and in the diagnosis and management of cardiac sequela in bronchopulmonary dysplasia. Troponin I/T finds its clinical importance in perinatal asphyxia as a marker of myocardial injury and a reliable indicator of severity and mortality. Further studies with larger cohort populations are needed for stablishing the cutoff values specific for each neonatal pathology allowing its early and proper management.https://www.jpnim.com/index.php/jpnim/article/view/533cardiac biomarkersbnptroponinck-mbmyoglobinneonatal intensive care |
| spellingShingle | Rita P. Teixeira Ana L. Neves Hercília Guimarães Cardiac biomarkers in neonatology: BNP/NTproBNP, troponin I/T, CK-MB and myoglobin – a systematic review Journal of Pediatric and Neonatal Individualized Medicine cardiac biomarkers bnp troponin ck-mb myoglobin neonatal intensive care |
| title | Cardiac biomarkers in neonatology: BNP/NTproBNP, troponin I/T, CK-MB and myoglobin – a systematic review |
| title_full | Cardiac biomarkers in neonatology: BNP/NTproBNP, troponin I/T, CK-MB and myoglobin – a systematic review |
| title_fullStr | Cardiac biomarkers in neonatology: BNP/NTproBNP, troponin I/T, CK-MB and myoglobin – a systematic review |
| title_full_unstemmed | Cardiac biomarkers in neonatology: BNP/NTproBNP, troponin I/T, CK-MB and myoglobin – a systematic review |
| title_short | Cardiac biomarkers in neonatology: BNP/NTproBNP, troponin I/T, CK-MB and myoglobin – a systematic review |
| title_sort | cardiac biomarkers in neonatology bnp ntprobnp troponin i t ck mb and myoglobin a systematic review |
| topic | cardiac biomarkers bnp troponin ck-mb myoglobin neonatal intensive care |
| url | https://www.jpnim.com/index.php/jpnim/article/view/533 |
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