Associations between bone mineral density and chronic obstructive pulmonary disease
Abstract Objective To assess the relationship between chronic obstructive pulmonary disease (COPD) severity and bone mineral density (BMD) in the whole body and different body areas. Methods This retrospective, cross-sectional study included patients with COPD. Demographic and lung function data, CO...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-05-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605221094644 |
| _version_ | 1811335680428605440 |
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| author | Xiaodiao Zhang Keke Ding Xiaqi Miao Jianing Wang Binbin Hu Jiamin Shen Xueting Hu Yage Xu Beibei Yu Tingting Tu Aiju Lin Xianjing Chen Yiben Huang |
| author_facet | Xiaodiao Zhang Keke Ding Xiaqi Miao Jianing Wang Binbin Hu Jiamin Shen Xueting Hu Yage Xu Beibei Yu Tingting Tu Aiju Lin Xianjing Chen Yiben Huang |
| author_sort | Xiaodiao Zhang |
| collection | DOAJ |
| description | Abstract Objective To assess the relationship between chronic obstructive pulmonary disease (COPD) severity and bone mineral density (BMD) in the whole body and different body areas. Methods This retrospective, cross-sectional study included patients with COPD. Demographic and lung function data, COPD severity scales, BMD, and T scores were collected. Patients were grouped by high (≥–1) and low (<–1) T scores, and stratified by body mass index, airway obstruction, dyspnoea, and exercise capacity (BODE) index. The relationship between whole-body BMD and BODE was evaluated by Kendall’s tau-b correlation coefficient. Risk factors associated with COPD severity were identified by univariate analyses. BMD as an independent predictor of severe COPD (BODE ≥5) was verified by multivariate logistic regression. BMD values in different body areas for predicting severe COPD were assessed by receiver operating characteristic curves. Results Of 88 patients with COPD, lung-function indicators and COPD severity were significantly different between those with high and low T scores. Whole-body BMD was inversely related to COPD severity scales, including BODE. Multivariate logistic regression revealed that BMD was independently associated with COPD severity. The area under the curve for pelvic BMD in predicting severe COPD was 0.728. Conclusion BMD may be a novel marker in predicting COPD severity, and pelvic BMD may have the strongest relative predictive power. |
| first_indexed | 2024-04-13T17:27:51Z |
| format | Article |
| id | doaj.art-6d1bdf5f3ad5456f9f25328d6660bcc4 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-04-13T17:27:51Z |
| publishDate | 2022-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-6d1bdf5f3ad5456f9f25328d6660bcc42022-12-22T02:37:41ZengSAGE PublishingJournal of International Medical Research1473-23002022-05-015010.1177/03000605221094644Associations between bone mineral density and chronic obstructive pulmonary diseaseXiaodiao ZhangKeke DingXiaqi MiaoJianing WangBinbin HuJiamin ShenXueting HuYage XuBeibei YuTingting TuAiju LinXianjing ChenYiben HuangAbstract Objective To assess the relationship between chronic obstructive pulmonary disease (COPD) severity and bone mineral density (BMD) in the whole body and different body areas. Methods This retrospective, cross-sectional study included patients with COPD. Demographic and lung function data, COPD severity scales, BMD, and T scores were collected. Patients were grouped by high (≥–1) and low (<–1) T scores, and stratified by body mass index, airway obstruction, dyspnoea, and exercise capacity (BODE) index. The relationship between whole-body BMD and BODE was evaluated by Kendall’s tau-b correlation coefficient. Risk factors associated with COPD severity were identified by univariate analyses. BMD as an independent predictor of severe COPD (BODE ≥5) was verified by multivariate logistic regression. BMD values in different body areas for predicting severe COPD were assessed by receiver operating characteristic curves. Results Of 88 patients with COPD, lung-function indicators and COPD severity were significantly different between those with high and low T scores. Whole-body BMD was inversely related to COPD severity scales, including BODE. Multivariate logistic regression revealed that BMD was independently associated with COPD severity. The area under the curve for pelvic BMD in predicting severe COPD was 0.728. Conclusion BMD may be a novel marker in predicting COPD severity, and pelvic BMD may have the strongest relative predictive power.https://doi.org/10.1177/03000605221094644 |
| spellingShingle | Xiaodiao Zhang Keke Ding Xiaqi Miao Jianing Wang Binbin Hu Jiamin Shen Xueting Hu Yage Xu Beibei Yu Tingting Tu Aiju Lin Xianjing Chen Yiben Huang Associations between bone mineral density and chronic obstructive pulmonary disease Journal of International Medical Research |
| title | Associations between bone mineral density and chronic obstructive pulmonary disease |
| title_full | Associations between bone mineral density and chronic obstructive pulmonary disease |
| title_fullStr | Associations between bone mineral density and chronic obstructive pulmonary disease |
| title_full_unstemmed | Associations between bone mineral density and chronic obstructive pulmonary disease |
| title_short | Associations between bone mineral density and chronic obstructive pulmonary disease |
| title_sort | associations between bone mineral density and chronic obstructive pulmonary disease |
| url | https://doi.org/10.1177/03000605221094644 |
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