The burden associated with generalized pustular psoriasis: A Canadian population-based study of inpatient care, emergency departments, and hospital- or community-based outpatient clinicsCapsule Summary
Background: Not much is known about the burden of generalized pustular psoriasis (GPP). Objectives: To document the burden of GPP in Canada and to compare it with psoriasis vulgaris (PV). Methods: National data were used to identify Canadian adult patients with GPP or PV hospitalized or visiting an...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | JAAD International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666328723000597 |
| _version_ | 1797744269155368960 |
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| author | Jean-Eric Tarride, MA, PhD Vimal H. Prajapati, MD Charles Lynde, MD Gord Blackhouse, MA, MBA |
| author_facet | Jean-Eric Tarride, MA, PhD Vimal H. Prajapati, MD Charles Lynde, MD Gord Blackhouse, MA, MBA |
| author_sort | Jean-Eric Tarride, MA, PhD |
| collection | DOAJ |
| description | Background: Not much is known about the burden of generalized pustular psoriasis (GPP). Objectives: To document the burden of GPP in Canada and to compare it with psoriasis vulgaris (PV). Methods: National data were used to identify Canadian adult patients with GPP or PV hospitalized or visiting an emergency department (ED) or hospital-/community-based clinic between April 1, 2007, and March 31, 2020. Analyses of 10-year prevalence and 3-year incidence were conducted. Costs were determined when the most responsible diagnosis (MRD) was GPP or PV (MRD costs) and for all reasons (all-cause costs). Results: In the prevalence analysis, 10-year mean (SD) MRD costs were $2393 ($11,410) for patients with GPP and $222 ($1828) for those with PV (P < .01). In the incidence analysis, patients with GPP had higher 3-year mean (SD) MRD costs ($3477 [$14,979] vs $503 [$2267] for PV; P < .01). Higher all-cause costs were also associated with patients with GPP. Inpatient/ED mortality was higher in the GPP group in our 10-year prevalence (9.2% for patients with GPP vs 7.3% for those with PV; P = .01) and 3-year incidence (5.2% for patients with GPP and 2.1% for those with PV; P = .03) analyses. Limitations: Physician and prescription drug data were not available. Conclusion: Patients with GPP incurred higher costs and mortality than patients with PV. |
| first_indexed | 2024-03-12T15:08:15Z |
| format | Article |
| id | doaj.art-6d1bf44b9384494aac0887ad82acab21 |
| institution | Directory Open Access Journal |
| issn | 2666-3287 |
| language | English |
| last_indexed | 2024-03-12T15:08:15Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JAAD International |
| spelling | doaj.art-6d1bf44b9384494aac0887ad82acab212023-08-12T04:34:54ZengElsevierJAAD International2666-32872023-09-01129098The burden associated with generalized pustular psoriasis: A Canadian population-based study of inpatient care, emergency departments, and hospital- or community-based outpatient clinicsCapsule SummaryJean-Eric Tarride, MA, PhD0Vimal H. Prajapati, MD1Charles Lynde, MD2Gord Blackhouse, MA, MBA3Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, Canada; Correspondence to: Jean-Eric Tarride, MA, PhD (Economics), McMaster Chair in Health Technology Management, Department of Health Research Methods, Evidence, and Impact (HEI), Faculty of Health Sciences, McMaster University, Communication Research Lab (CRL) 227, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8K 4K1; Tel: 905-525-9140, ext. 20205.Division of Dermatology, Department of Medicine; Section of Community Pediatrics, Department of Pediatrics; and Section of Pediatric Rheumatology, Department of Pediatrics, University of Calgary, Calgary, Canada; Skin Health & Wellness Centre, Calgary, Canada; Dermatology Research Institute, Calgary, Canada; and Probity Medical Research, Calgary, CanadaDepartment of Medicine, University of Toronto, Toronto, CanadaDepartment of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, CanadaBackground: Not much is known about the burden of generalized pustular psoriasis (GPP). Objectives: To document the burden of GPP in Canada and to compare it with psoriasis vulgaris (PV). Methods: National data were used to identify Canadian adult patients with GPP or PV hospitalized or visiting an emergency department (ED) or hospital-/community-based clinic between April 1, 2007, and March 31, 2020. Analyses of 10-year prevalence and 3-year incidence were conducted. Costs were determined when the most responsible diagnosis (MRD) was GPP or PV (MRD costs) and for all reasons (all-cause costs). Results: In the prevalence analysis, 10-year mean (SD) MRD costs were $2393 ($11,410) for patients with GPP and $222 ($1828) for those with PV (P < .01). In the incidence analysis, patients with GPP had higher 3-year mean (SD) MRD costs ($3477 [$14,979] vs $503 [$2267] for PV; P < .01). Higher all-cause costs were also associated with patients with GPP. Inpatient/ED mortality was higher in the GPP group in our 10-year prevalence (9.2% for patients with GPP vs 7.3% for those with PV; P = .01) and 3-year incidence (5.2% for patients with GPP and 2.1% for those with PV; P = .03) analyses. Limitations: Physician and prescription drug data were not available. Conclusion: Patients with GPP incurred higher costs and mortality than patients with PV.http://www.sciencedirect.com/science/article/pii/S2666328723000597Canadageneralized pustular psoriasishealthcare expendituresinpatient mortality |
| spellingShingle | Jean-Eric Tarride, MA, PhD Vimal H. Prajapati, MD Charles Lynde, MD Gord Blackhouse, MA, MBA The burden associated with generalized pustular psoriasis: A Canadian population-based study of inpatient care, emergency departments, and hospital- or community-based outpatient clinicsCapsule Summary JAAD International Canada generalized pustular psoriasis healthcare expenditures inpatient mortality |
| title | The burden associated with generalized pustular psoriasis: A Canadian population-based study of inpatient care, emergency departments, and hospital- or community-based outpatient clinicsCapsule Summary |
| title_full | The burden associated with generalized pustular psoriasis: A Canadian population-based study of inpatient care, emergency departments, and hospital- or community-based outpatient clinicsCapsule Summary |
| title_fullStr | The burden associated with generalized pustular psoriasis: A Canadian population-based study of inpatient care, emergency departments, and hospital- or community-based outpatient clinicsCapsule Summary |
| title_full_unstemmed | The burden associated with generalized pustular psoriasis: A Canadian population-based study of inpatient care, emergency departments, and hospital- or community-based outpatient clinicsCapsule Summary |
| title_short | The burden associated with generalized pustular psoriasis: A Canadian population-based study of inpatient care, emergency departments, and hospital- or community-based outpatient clinicsCapsule Summary |
| title_sort | burden associated with generalized pustular psoriasis a canadian population based study of inpatient care emergency departments and hospital or community based outpatient clinicscapsule summary |
| topic | Canada generalized pustular psoriasis healthcare expenditures inpatient mortality |
| url | http://www.sciencedirect.com/science/article/pii/S2666328723000597 |
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