Effects of Copper Nanoparticles in Prostate Normal and Cancer Cell Lines
Background and purpose: In clinical treatment of cancer, improving the efficacy of drugs and targeted drug delivery have always been a fundamental problem requiring more focused solutions. The purpose of this study was to investigate the protective effects of copper nanoparticles in prostate normal...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2023-05-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-18889-en.pdf |
| _version_ | 1827698701585350656 |
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| author | Mohammad Shokrzadeh Bahare Sayad Shaghayegh Aghajanshakeri |
| author_facet | Mohammad Shokrzadeh Bahare Sayad Shaghayegh Aghajanshakeri |
| author_sort | Mohammad Shokrzadeh |
| collection | DOAJ |
| description | Background and purpose: In clinical treatment of cancer, improving the efficacy of drugs and targeted drug delivery have always been a fundamental problem requiring more focused solutions. The purpose of this study was to investigate the protective effects of copper nanoparticles in prostate normal and cancer cell lines.
Materials and methods: In this experimental study, different concentrations of copper nanoparticles (0, 25, 50, 100, 150, 200, 250, 300, and 600 μg) were prepared. Cell growth and oxidative stress in reactive oxygen species (ROS) and reduced glutathione (GSH) were studied in prostate normal and cancer cell lines using MTT assay.
Results: Copper nanoparticles created toxicity in prostate normal cells due to release of ROS and reduction of glutathione reserves. Also, this mechanism inhibited the growth of cancer cells.
Conclusion: According to this study, copper nanoparticles induced toxicity in normal cells through oxidative stress pathway and inducing ROS and decreased the growth of normal cells. Also, copper nanoparticles inhibited the growth of cancer cells by the oxidative stress pathway. So, copper nanoparticles cannot be an effective drug in treatment of prostate cancer as they cause high toxicity in normal cells. |
| first_indexed | 2024-03-10T13:33:54Z |
| format | Article |
| id | doaj.art-6d1c34c571294ba8b81221c8fb4f830f |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-03-10T13:33:54Z |
| publishDate | 2023-05-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-6d1c34c571294ba8b81221c8fb4f830f2023-11-21T07:41:33ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792023-05-0133220187193Effects of Copper Nanoparticles in Prostate Normal and Cancer Cell LinesMohammad Shokrzadeh0Bahare Sayad1Shaghayegh Aghajanshakeri2 Professor, Department of Toxicology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Pharmacy Student, Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran PhD in Toxicology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Background and purpose: In clinical treatment of cancer, improving the efficacy of drugs and targeted drug delivery have always been a fundamental problem requiring more focused solutions. The purpose of this study was to investigate the protective effects of copper nanoparticles in prostate normal and cancer cell lines. Materials and methods: In this experimental study, different concentrations of copper nanoparticles (0, 25, 50, 100, 150, 200, 250, 300, and 600 μg) were prepared. Cell growth and oxidative stress in reactive oxygen species (ROS) and reduced glutathione (GSH) were studied in prostate normal and cancer cell lines using MTT assay. Results: Copper nanoparticles created toxicity in prostate normal cells due to release of ROS and reduction of glutathione reserves. Also, this mechanism inhibited the growth of cancer cells. Conclusion: According to this study, copper nanoparticles induced toxicity in normal cells through oxidative stress pathway and inducing ROS and decreased the growth of normal cells. Also, copper nanoparticles inhibited the growth of cancer cells by the oxidative stress pathway. So, copper nanoparticles cannot be an effective drug in treatment of prostate cancer as they cause high toxicity in normal cells.http://jmums.mazums.ac.ir/article-1-18889-en.pdfcopper nanoparticlenormal cellprostate cancer celloxidative stress |
| spellingShingle | Mohammad Shokrzadeh Bahare Sayad Shaghayegh Aghajanshakeri Effects of Copper Nanoparticles in Prostate Normal and Cancer Cell Lines Journal of Mazandaran University of Medical Sciences copper nanoparticle normal cell prostate cancer cell oxidative stress |
| title | Effects of Copper Nanoparticles in Prostate Normal and
Cancer Cell Lines |
| title_full | Effects of Copper Nanoparticles in Prostate Normal and
Cancer Cell Lines |
| title_fullStr | Effects of Copper Nanoparticles in Prostate Normal and
Cancer Cell Lines |
| title_full_unstemmed | Effects of Copper Nanoparticles in Prostate Normal and
Cancer Cell Lines |
| title_short | Effects of Copper Nanoparticles in Prostate Normal and
Cancer Cell Lines |
| title_sort | effects of copper nanoparticles in prostate normal and cancer cell lines |
| topic | copper nanoparticle normal cell prostate cancer cell oxidative stress |
| url | http://jmums.mazums.ac.ir/article-1-18889-en.pdf |
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