Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-inflammatory Effects through SHIP1/STAT3 Complexes

Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-inflammatory Effects through SHIP1/STAT3 Complexes

Summary: The anti-inflammatory actions of interleukin-10 (IL10) are thought to be mediated primarily by the STAT3 transcription factor, but pro-inflammatory cytokines such as interleukin-6 (IL6) also act through STAT3. We now report that IL10, but not IL6 signaling, induces formation of a complex be...

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Bibliographic Details
Main Authors: Thomas C. Chamberlain, Sylvia T. Cheung, Jeff S.J. Yoon, Andrew Ming-Lum, Bernd R. Gardill, Soroush Shakibakho, Edis Dzananovic, Fuqiang Ban, Abrar Samiea, Kamaldeep Jawanda, John Priatel, Gerald Krystal, Christopher J. Ong, Artem Cherkasov, Raymond J. Andersen, Sean A. McKenna, Filip Van Petegem, Alice L-F. Mui
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:iScience
Subjects:
Molecular Biology
Molecular Interaction
Immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220306234

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