Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence
Jin-Xiu Pan et al. report that an osteoblast-specific expression of Swedish mutant amyloid precursor protein (APPswe) induces ER stress-driven senescence, leading to systemic inflammation and inflammation in the cortex that drives behavioral changes. The results demonstrate a previously unrecognized...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02843-2 |
| _version_ | 1818841119692161024 |
|---|---|
| author | Jin-Xiu Pan Dong Sun Daehoon Lee Lei Xiong Xiao Ren Hao-han Guo Ling-Ling Yao Yuyi Lu Caroline Jung Wen-Cheng Xiong |
| author_facet | Jin-Xiu Pan Dong Sun Daehoon Lee Lei Xiong Xiao Ren Hao-han Guo Ling-Ling Yao Yuyi Lu Caroline Jung Wen-Cheng Xiong |
| author_sort | Jin-Xiu Pan |
| collection | DOAJ |
| description | Jin-Xiu Pan et al. report that an osteoblast-specific expression of Swedish mutant amyloid precursor protein (APPswe) induces ER stress-driven senescence, leading to systemic inflammation and inflammation in the cortex that drives behavioral changes. The results demonstrate a previously unrecognized function of osteoblastic APPswe to brain axis in AD development. |
| first_indexed | 2024-12-19T04:21:01Z |
| format | Article |
| id | doaj.art-6d1fdf67c02a4431b8721cdb4dab2785 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-19T04:21:01Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-6d1fdf67c02a4431b8721cdb4dab27852022-12-21T20:36:10ZengNature PortfolioCommunications Biology2399-36422021-11-014111610.1038/s42003-021-02843-2Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescenceJin-Xiu Pan0Dong Sun1Daehoon Lee2Lei Xiong3Xiao Ren4Hao-han Guo5Ling-Ling Yao6Yuyi Lu7Caroline Jung8Wen-Cheng Xiong9Department of Neurosciences, School of Medicine, Case Western Reserve UniversityDepartment of Neurosciences, School of Medicine, Case Western Reserve UniversityDepartment of Neurosciences, School of Medicine, Case Western Reserve UniversityDepartment of Neurosciences, School of Medicine, Case Western Reserve UniversityDepartment of Neurosciences, School of Medicine, Case Western Reserve UniversityDepartment of Neurosciences, School of Medicine, Case Western Reserve UniversityDepartment of Neurosciences, School of Medicine, Case Western Reserve UniversityDepartment of Neurosciences, School of Medicine, Case Western Reserve UniversityDepartment of Neurosciences, School of Medicine, Case Western Reserve UniversityDepartment of Neurosciences, School of Medicine, Case Western Reserve UniversityJin-Xiu Pan et al. report that an osteoblast-specific expression of Swedish mutant amyloid precursor protein (APPswe) induces ER stress-driven senescence, leading to systemic inflammation and inflammation in the cortex that drives behavioral changes. The results demonstrate a previously unrecognized function of osteoblastic APPswe to brain axis in AD development.https://doi.org/10.1038/s42003-021-02843-2 |
| spellingShingle | Jin-Xiu Pan Dong Sun Daehoon Lee Lei Xiong Xiao Ren Hao-han Guo Ling-Ling Yao Yuyi Lu Caroline Jung Wen-Cheng Xiong Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence Communications Biology |
| title | Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence |
| title_full | Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence |
| title_fullStr | Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence |
| title_full_unstemmed | Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence |
| title_short | Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence |
| title_sort | osteoblastic swedish mutant app expedites brain deficits by inducing endoplasmic reticulum stress driven senescence |
| url | https://doi.org/10.1038/s42003-021-02843-2 |
| work_keys_str_mv | AT jinxiupan osteoblasticswedishmutantappexpeditesbraindeficitsbyinducingendoplasmicreticulumstressdrivensenescence AT dongsun osteoblasticswedishmutantappexpeditesbraindeficitsbyinducingendoplasmicreticulumstressdrivensenescence AT daehoonlee osteoblasticswedishmutantappexpeditesbraindeficitsbyinducingendoplasmicreticulumstressdrivensenescence AT leixiong osteoblasticswedishmutantappexpeditesbraindeficitsbyinducingendoplasmicreticulumstressdrivensenescence AT xiaoren osteoblasticswedishmutantappexpeditesbraindeficitsbyinducingendoplasmicreticulumstressdrivensenescence AT haohanguo osteoblasticswedishmutantappexpeditesbraindeficitsbyinducingendoplasmicreticulumstressdrivensenescence AT linglingyao osteoblasticswedishmutantappexpeditesbraindeficitsbyinducingendoplasmicreticulumstressdrivensenescence AT yuyilu osteoblasticswedishmutantappexpeditesbraindeficitsbyinducingendoplasmicreticulumstressdrivensenescence AT carolinejung osteoblasticswedishmutantappexpeditesbraindeficitsbyinducingendoplasmicreticulumstressdrivensenescence AT wenchengxiong osteoblasticswedishmutantappexpeditesbraindeficitsbyinducingendoplasmicreticulumstressdrivensenescence |