Differences in Medication Adherence between Living and Deceased Donor Kidney Transplant Patients
Background: Literature review suggests that adherence to immunosuppressive drugs may be lower in recipients of living than of deceased donor kidney grafts, possibly because of profile differences. Objective: To compare the level of immunosuppressive adherence levels between patients with deceased a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2014-01-01
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| Series: | International Journal of Organ Transplantation Medicine |
| Subjects: | |
| Online Access: | http://www.ijotm.com/ojs/index.php/IJOTM/article/view/166 |
| _version_ | 1818460212873396224 |
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| author | K Denhaerynck G Schmid-Mohler A Kiss J Steiger R W�thrich A Bock S De Geest |
| author_facet | K Denhaerynck G Schmid-Mohler A Kiss J Steiger R W�thrich A Bock S De Geest |
| author_sort | K Denhaerynck |
| collection | DOAJ |
| description | Background: Literature review suggests that adherence to immunosuppressive drugs may be lower in recipients of living than of deceased donor kidney grafts, possibly because of profile differences.
Objective: To compare the level of immunosuppressive adherence levels between patients with deceased and living (-related; -unrelated) donor grafts in Switzerland.
Methods: Using data from two similar cross-sectional studies at two transplant centers in Switzerland, the level of adherence between the two groups was compared. Medication adherence was assessed by self-report or electronic monitoring. Possible explanatory factors included age, beliefs regarding immunosuppressive drugs, depressive symptomatology, pre-emptive transplantation, and the number of transplants received, were also considered. Data were analyzed using logistic regression analysis.
Results: Unadjusted non-adherence odds were 2 to 3 times higher in living-related than deceased donor transplantation (ORs: 2.09-3.05; p<0.05). Adjustment for confounders showed that these differences were associated most with the younger age of living-related subjects and the belief that immunosuppressive drugs are less important for living-related donations.
Conclusion: There is a lower immunosuppressive adherence in recipients of living-related donor kidneys, possibly owing to differences in patient profile (ie, health beliefs regarding their immunosuppressive needs), knowledge of which may enhance adherence if addressed. |
| first_indexed | 2024-12-14T23:26:40Z |
| format | Article |
| id | doaj.art-6d20c18d03f64e79a409413b9ab5afef |
| institution | Directory Open Access Journal |
| issn | 2008-6482 2008-6490 |
| language | English |
| last_indexed | 2024-12-14T23:26:40Z |
| publishDate | 2014-01-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | International Journal of Organ Transplantation Medicine |
| spelling | doaj.art-6d20c18d03f64e79a409413b9ab5afef2022-12-21T22:43:46ZengShiraz University of Medical SciencesInternational Journal of Organ Transplantation Medicine2008-64822008-64902014-01-0151144Differences in Medication Adherence between Living and Deceased Donor Kidney Transplant PatientsK Denhaerynck0G Schmid-Mohler1A Kiss2J Steiger3R W�thrich4A Bock5S De Geest6Institute of Nursing Science, University of Basel, SwitzerlandDivision of Nephrology, University Hospital Z�rich, SwitzerlandDivision of Psychosomatic Medicine, University Hospital Basel, SwitzerlandTransplantation Immunology and Nephrology, University Hospital Basel, SwitzerlandDivision of Nephrology, University Hospital Z�rich, SwitzerlandDivision of Nephrology, Kantonsspital, Aarau, SwitzerlandCenter of Health Services and Nursing Research, K.U. Leuven, Leuven, BelgiumBackground: Literature review suggests that adherence to immunosuppressive drugs may be lower in recipients of living than of deceased donor kidney grafts, possibly because of profile differences. Objective: To compare the level of immunosuppressive adherence levels between patients with deceased and living (-related; -unrelated) donor grafts in Switzerland. Methods: Using data from two similar cross-sectional studies at two transplant centers in Switzerland, the level of adherence between the two groups was compared. Medication adherence was assessed by self-report or electronic monitoring. Possible explanatory factors included age, beliefs regarding immunosuppressive drugs, depressive symptomatology, pre-emptive transplantation, and the number of transplants received, were also considered. Data were analyzed using logistic regression analysis. Results: Unadjusted non-adherence odds were 2 to 3 times higher in living-related than deceased donor transplantation (ORs: 2.09-3.05; p<0.05). Adjustment for confounders showed that these differences were associated most with the younger age of living-related subjects and the belief that immunosuppressive drugs are less important for living-related donations. Conclusion: There is a lower immunosuppressive adherence in recipients of living-related donor kidneys, possibly owing to differences in patient profile (ie, health beliefs regarding their immunosuppressive needs), knowledge of which may enhance adherence if addressed.http://www.ijotm.com/ojs/index.php/IJOTM/article/view/166Living related transplantationImmunosuppressant adherenceKidney transplantationDonorGraft |
| spellingShingle | K Denhaerynck G Schmid-Mohler A Kiss J Steiger R W�thrich A Bock S De Geest Differences in Medication Adherence between Living and Deceased Donor Kidney Transplant Patients International Journal of Organ Transplantation Medicine Living related transplantation Immunosuppressant adherence Kidney transplantation Donor Graft |
| title | Differences in Medication Adherence between Living and Deceased Donor Kidney Transplant Patients |
| title_full | Differences in Medication Adherence between Living and Deceased Donor Kidney Transplant Patients |
| title_fullStr | Differences in Medication Adherence between Living and Deceased Donor Kidney Transplant Patients |
| title_full_unstemmed | Differences in Medication Adherence between Living and Deceased Donor Kidney Transplant Patients |
| title_short | Differences in Medication Adherence between Living and Deceased Donor Kidney Transplant Patients |
| title_sort | differences in medication adherence between living and deceased donor kidney transplant patients |
| topic | Living related transplantation Immunosuppressant adherence Kidney transplantation Donor Graft |
| url | http://www.ijotm.com/ojs/index.php/IJOTM/article/view/166 |
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