Biomaterial scaffolds for clinical procedures in endodontic regeneration
Regenerative endodontic procedures have been rapidly evolving over the past two decades and are employed extensively in clinical endodontics. These procedures have been perceived as valuable adjuvants to conventional strategies in the treatment of necrotic immature permanent teeth that were deemed t...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-06-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X21004679 |
| _version_ | 1827280567300784128 |
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| author | He Liu Jing Lu Qianzhou Jiang Markus Haapasalo Junrong Qian Franklin R. Tay Ya Shen |
| author_facet | He Liu Jing Lu Qianzhou Jiang Markus Haapasalo Junrong Qian Franklin R. Tay Ya Shen |
| author_sort | He Liu |
| collection | DOAJ |
| description | Regenerative endodontic procedures have been rapidly evolving over the past two decades and are employed extensively in clinical endodontics. These procedures have been perceived as valuable adjuvants to conventional strategies in the treatment of necrotic immature permanent teeth that were deemed to have poor prognosis. As a component biological triad of tissue engineering (i.e., stem cells, growth factors and scaffolds), biomaterial scaffolds have demonstrated clinical potential as an armamentarium in regenerative endodontic procedures and achieved remarkable advancements. The aim of the present review is to provide a broad overview of biomaterials employed for scaffolding in regenerative endodontics. The favorable properties and limitations of biomaterials organized in naturally derived, host-derived and synthetic material categories were discussed. Preclinical and clinical studies published over the past five years on the performance of biomaterial scaffolds, as well as current challenges and future perspectives for the application of biomaterials for scaffolding and clinical evaluation of biomaterial scaffolds in regenerative endodontic procedures were addressed in depth. |
| first_indexed | 2024-04-24T08:43:14Z |
| format | Article |
| id | doaj.art-6d219fa8cf3e430191d7b895e609ec09 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:43:14Z |
| publishDate | 2022-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-6d219fa8cf3e430191d7b895e609ec092024-04-16T14:44:15ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2022-06-0112257277Biomaterial scaffolds for clinical procedures in endodontic regenerationHe Liu0Jing Lu1Qianzhou Jiang2Markus Haapasalo3Junrong Qian4Franklin R. Tay5Ya Shen6Department of Stomatology, Affiliated Hospital of Jining Medical University, China; Division of Endodontics, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, CanadaKey Laboratory of Oral Disease, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, ChinaDepartment of Endodontics, Stomatology Hospital of Guangzhou Medical University, Guangzhou, ChinaDivision of Endodontics, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, CanadaDepartment of Stomatology, Affiliated Hospital of Jining Medical University, China; Department of Stomatology, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272000, China.Department of Endodontics, The Dental College of Georgia, Augusta University, Augusta, GA, USA; Corresponding author. Augusta University, Augusta, GA, USA.Division of Endodontics, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Canada; Corresponding author. UBC Faculty of Dentistry, 2199, Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.Regenerative endodontic procedures have been rapidly evolving over the past two decades and are employed extensively in clinical endodontics. These procedures have been perceived as valuable adjuvants to conventional strategies in the treatment of necrotic immature permanent teeth that were deemed to have poor prognosis. As a component biological triad of tissue engineering (i.e., stem cells, growth factors and scaffolds), biomaterial scaffolds have demonstrated clinical potential as an armamentarium in regenerative endodontic procedures and achieved remarkable advancements. The aim of the present review is to provide a broad overview of biomaterials employed for scaffolding in regenerative endodontics. The favorable properties and limitations of biomaterials organized in naturally derived, host-derived and synthetic material categories were discussed. Preclinical and clinical studies published over the past five years on the performance of biomaterial scaffolds, as well as current challenges and future perspectives for the application of biomaterials for scaffolding and clinical evaluation of biomaterial scaffolds in regenerative endodontic procedures were addressed in depth.http://www.sciencedirect.com/science/article/pii/S2452199X21004679BiomaterialsClinical approachRegenerative endodonticsScaffolds |
| spellingShingle | He Liu Jing Lu Qianzhou Jiang Markus Haapasalo Junrong Qian Franklin R. Tay Ya Shen Biomaterial scaffolds for clinical procedures in endodontic regeneration Bioactive Materials Biomaterials Clinical approach Regenerative endodontics Scaffolds |
| title | Biomaterial scaffolds for clinical procedures in endodontic regeneration |
| title_full | Biomaterial scaffolds for clinical procedures in endodontic regeneration |
| title_fullStr | Biomaterial scaffolds for clinical procedures in endodontic regeneration |
| title_full_unstemmed | Biomaterial scaffolds for clinical procedures in endodontic regeneration |
| title_short | Biomaterial scaffolds for clinical procedures in endodontic regeneration |
| title_sort | biomaterial scaffolds for clinical procedures in endodontic regeneration |
| topic | Biomaterials Clinical approach Regenerative endodontics Scaffolds |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X21004679 |
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