CD44 Promotes Breast Cancer Metastasis through AKT-Mediated Downregulation of Nuclear FOXA2
The primary cause of breast cancer mortality is the metastatic invasion of cancerous stem cells (CSC). Cluster of differentiation 44 (CD44) is a well-known CSC marker in various cancers, as well as a key role player in metastasis and relapse of breast cancer. CD44 is a cell-membrane embedded protein...
Main Authors: | Anupama Vadhan, Ming-Feng Hou, Priya Vijayaraghavan, Yi-Chia Wu, Stephen Chu-Sung Hu, Yun-Ming Wang, Tian-Lu Cheng, Yen-Yun Wang, Shyng-Shiou F. Yuan |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-10-01
|
Series: | Biomedicines |
Subjects: | |
Online Access: | https://www.mdpi.com/2227-9059/10/10/2488 |
Similar Items
-
Opposing Roles of FoxA1 and FoxA3 in Intrahepatic Cholangiocarcinoma Progression
by: Raynoo Thanan, et al.
Published: (2020-03-01) -
CD44 Promotes Lung Cancer Cell Metastasis through ERK–ZEB1 Signaling
by: Yen-Yun Wang, et al.
Published: (2021-08-01) -
Comparing the Expression of Foxa1 and Foxa2 Genes in the Stomach in Men and Women
by: Zahra Mohammadi, et al.
Published: (2015-11-01) -
FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer
by: Soledad A Camolotto, et al.
Published: (2018-11-01) -
Effects of Silymarin on Blood Glucose Concentration, Hepatic Histopathological Changes and FOXA2 and FOXA3 Gene Expression in Streptozotocin-Induced Diabetic Male Wistar Rats
by: Sajad Nikkhah, et al.
Published: (2021-12-01)