Soluble AXL as a marker of disease progression and survival in melanoma.

Soluble AXL as a marker of disease progression and survival in melanoma.

Receptor tyrosine kinase AXL is a one-pass transmembrane protein upregulated in cancers and associated with lower survival and therapy resistance. AXL can be cleaved by the A Disintegrin and Metalloproteinases (ADAM)10 and ADAM17, yielding a soluble version of the protein. Elevated soluble AXL (sAXL...

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Bibliographic Details
Main Authors: Karine Flem-Karlsen, Marta Nyakas, Inger Nina Farstad, Erin McFadden, Patrik Wernhoff, Kari Dolven Jacobsen, Vivi Ann Flørenes, Gunhild Mari Mælandsmo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0227187

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