Quadrivalent mosaic HexaPro-bearing nanoparticle vaccine protects against infection of SARS-CoV-2 variants
Emerging SARS-CoV-2 variants with multiple mutations raise concerns on vaccine effectiveness. Here, Kang et al. report that a quadrivalent mosaic nanoparticle vaccine displaying spike proteins from the SARS-CoV-2 prototype and three different VOCs confer protection against SARS-CoV-2 variants in mic...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30222-w |
| _version_ | 1818005796372348928 |
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| author | Yin-Feng Kang Cong Sun Jing Sun Chu Xie Zhen Zhuang Hui-Qin Xu Zheng Liu Yi-Hao Liu Sui Peng Run-Yu Yuan Jin-Cun Zhao Mu-Sheng Zeng |
| author_facet | Yin-Feng Kang Cong Sun Jing Sun Chu Xie Zhen Zhuang Hui-Qin Xu Zheng Liu Yi-Hao Liu Sui Peng Run-Yu Yuan Jin-Cun Zhao Mu-Sheng Zeng |
| author_sort | Yin-Feng Kang |
| collection | DOAJ |
| description | Emerging SARS-CoV-2 variants with multiple mutations raise concerns on vaccine effectiveness. Here, Kang et al. report that a quadrivalent mosaic nanoparticle vaccine displaying spike proteins from the SARS-CoV-2 prototype and three different VOCs confer protection against SARS-CoV-2 variants in mice. |
| first_indexed | 2024-04-14T04:51:06Z |
| format | Article |
| id | doaj.art-6d267d5d50804540b57f99b7a135e496 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-14T04:51:06Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6d267d5d50804540b57f99b7a135e4962022-12-22T02:11:18ZengNature PortfolioNature Communications2041-17232022-05-0113111510.1038/s41467-022-30222-wQuadrivalent mosaic HexaPro-bearing nanoparticle vaccine protects against infection of SARS-CoV-2 variantsYin-Feng Kang0Cong Sun1Jing Sun2Chu Xie3Zhen Zhuang4Hui-Qin Xu5Zheng Liu6Yi-Hao Liu7Sui Peng8Run-Yu Yuan9Jin-Cun Zhao10Mu-Sheng Zeng11State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Department of Experimental Research, Sun Yat-sen University Cancer Center (SYSUCC), Sun Yat-sen UniversityState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Department of Experimental Research, Sun Yat-sen University Cancer Center (SYSUCC), Sun Yat-sen UniversityState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Department of Experimental Research, Sun Yat-sen University Cancer Center (SYSUCC), Sun Yat-sen UniversityState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical UniversityCryo-electron Microscopy Center, Southern University of Science and TechnologyCryo-electron Microscopy Center, Southern University of Science and TechnologyInstitute of Precision Medicine, Clinical Trials Unit, The First Affiliated Hospital of Sun Yat-sen UniversityInstitute of Precision Medicine, Clinical Trials Unit, The First Affiliated Hospital of Sun Yat-sen UniversityGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and PreventionState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Department of Experimental Research, Sun Yat-sen University Cancer Center (SYSUCC), Sun Yat-sen UniversityEmerging SARS-CoV-2 variants with multiple mutations raise concerns on vaccine effectiveness. Here, Kang et al. report that a quadrivalent mosaic nanoparticle vaccine displaying spike proteins from the SARS-CoV-2 prototype and three different VOCs confer protection against SARS-CoV-2 variants in mice.https://doi.org/10.1038/s41467-022-30222-w |
| spellingShingle | Yin-Feng Kang Cong Sun Jing Sun Chu Xie Zhen Zhuang Hui-Qin Xu Zheng Liu Yi-Hao Liu Sui Peng Run-Yu Yuan Jin-Cun Zhao Mu-Sheng Zeng Quadrivalent mosaic HexaPro-bearing nanoparticle vaccine protects against infection of SARS-CoV-2 variants Nature Communications |
| title | Quadrivalent mosaic HexaPro-bearing nanoparticle vaccine protects against infection of SARS-CoV-2 variants |
| title_full | Quadrivalent mosaic HexaPro-bearing nanoparticle vaccine protects against infection of SARS-CoV-2 variants |
| title_fullStr | Quadrivalent mosaic HexaPro-bearing nanoparticle vaccine protects against infection of SARS-CoV-2 variants |
| title_full_unstemmed | Quadrivalent mosaic HexaPro-bearing nanoparticle vaccine protects against infection of SARS-CoV-2 variants |
| title_short | Quadrivalent mosaic HexaPro-bearing nanoparticle vaccine protects against infection of SARS-CoV-2 variants |
| title_sort | quadrivalent mosaic hexapro bearing nanoparticle vaccine protects against infection of sars cov 2 variants |
| url | https://doi.org/10.1038/s41467-022-30222-w |
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