Sensitive LC-MS/MS Method for the Quantification of Macrocyclic Gαq Protein Inhibitors in Biological Samples

Sensitive LC-MS/MS Method for the Quantification of Macrocyclic Gαq Protein Inhibitors in Biological Samples

The cyclic depsipeptide FR900359 (FR) isolated from the plant Ardisia crenata and produced by endosymbiotic bacteria acts as a selective Gq protein inhibitor. It is a powerful tool to study G protein-coupled receptor signaling, and has potential as a novel drug for the treatment of pulmonary disease...

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Bibliographic Details
Main Authors: Markus Kuschak, Jonathan G. Schlegel, Marion Schneider, Stefan Kehraus, Jan H. Voss, Alexander Seidinger, Michaela Matthey, Daniela Wenzel, Bernd K. Fleischmann, Gabriele M. König, Christa E. Müller
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Chemistry
Subjects:
drug levels
FR900359
Gq inhibitor
LC-MS/MS
preclinical experiments
quantification
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00833/full

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