Genetic analyses identify pleiotropy and causality for blood proteins and highlight Wnt/β-catenin signalling in migraine
Understanding of the causes and treatment of migraine is incomplete. Here, the authors detect pleiotropic genetic effects and causal relationships between migraine and 58 proteins that are largely distinct from migraine-associated loci identified by GWAS.
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30184-z |
| _version_ | 1818201357929152512 |
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| author | Hamzeh M. Tanha The International Headache Genetics Consortium Dale R. Nyholt |
| author_facet | Hamzeh M. Tanha The International Headache Genetics Consortium Dale R. Nyholt |
| author_sort | Hamzeh M. Tanha |
| collection | DOAJ |
| description | Understanding of the causes and treatment of migraine is incomplete. Here, the authors detect pleiotropic genetic effects and causal relationships between migraine and 58 proteins that are largely distinct from migraine-associated loci identified by GWAS. |
| first_indexed | 2024-12-12T02:52:17Z |
| format | Article |
| id | doaj.art-6d283772a7494853bc299f0832d1c2e3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-12T02:52:17Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6d283772a7494853bc299f0832d1c2e32022-12-22T00:40:51ZengNature PortfolioNature Communications2041-17232022-05-0113111110.1038/s41467-022-30184-zGenetic analyses identify pleiotropy and causality for blood proteins and highlight Wnt/β-catenin signalling in migraineHamzeh M. Tanha0The International Headache Genetics ConsortiumDale R. Nyholt1School of Biomedical Sciences, Faculty of Health, and Centre for Genomics and Personalised Health, Queensland University of Technology (QUT)School of Biomedical Sciences, Faculty of Health, and Centre for Genomics and Personalised Health, Queensland University of Technology (QUT)Understanding of the causes and treatment of migraine is incomplete. Here, the authors detect pleiotropic genetic effects and causal relationships between migraine and 58 proteins that are largely distinct from migraine-associated loci identified by GWAS.https://doi.org/10.1038/s41467-022-30184-z |
| spellingShingle | Hamzeh M. Tanha The International Headache Genetics Consortium Dale R. Nyholt Genetic analyses identify pleiotropy and causality for blood proteins and highlight Wnt/β-catenin signalling in migraine Nature Communications |
| title | Genetic analyses identify pleiotropy and causality for blood proteins and highlight Wnt/β-catenin signalling in migraine |
| title_full | Genetic analyses identify pleiotropy and causality for blood proteins and highlight Wnt/β-catenin signalling in migraine |
| title_fullStr | Genetic analyses identify pleiotropy and causality for blood proteins and highlight Wnt/β-catenin signalling in migraine |
| title_full_unstemmed | Genetic analyses identify pleiotropy and causality for blood proteins and highlight Wnt/β-catenin signalling in migraine |
| title_short | Genetic analyses identify pleiotropy and causality for blood proteins and highlight Wnt/β-catenin signalling in migraine |
| title_sort | genetic analyses identify pleiotropy and causality for blood proteins and highlight wnt β catenin signalling in migraine |
| url | https://doi.org/10.1038/s41467-022-30184-z |
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