Molecular Biomarkers in Perthes Disease: A Review
Background: Perthes disease is a juvenile form of osteonecrosis of the femoral head that affects children under the age of 15. One hundred years after its discovery, some light has been shed on its etiology and the biological factors relevant to its etiology and disease severity. Methods: The aim of...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/13/3/471 |
| _version_ | 1797624824242110464 |
|---|---|
| author | Vesna Spasovski Sanja Srzentić Dražilov Gordana Nikčević Zoran Baščarević Maja Stojiljković Sonja Pavlović Duško Spasovski |
| author_facet | Vesna Spasovski Sanja Srzentić Dražilov Gordana Nikčević Zoran Baščarević Maja Stojiljković Sonja Pavlović Duško Spasovski |
| author_sort | Vesna Spasovski |
| collection | DOAJ |
| description | Background: Perthes disease is a juvenile form of osteonecrosis of the femoral head that affects children under the age of 15. One hundred years after its discovery, some light has been shed on its etiology and the biological factors relevant to its etiology and disease severity. Methods: The aim of this study was to summarize the literature findings on the biological factors relevant to the pathogenesis of Perthes disease, their diagnostic and clinical significance, and their therapeutic potential. A special focus on candidate genes as susceptibility factors and factors relevant to clinical severity was made, where studies reporting clinical or preclinical results were considered as the inclusion criteria. PubMed databases were searched by two independent researchers. Sixty-eight articles were included in this review. Results on the factors relevant to vascular involvement and inflammatory molecules indicated as factors that contribute to impaired bone remodeling have been summarized. Moreover, several candidate genes relevant to an active phase of the disease have been suggested as possible biological therapeutic targets. Conclusions: Delineation of molecular biomarkers that underlie the pathophysiological process of Perthes disease can allow for the provision of earlier and more accurate diagnoses of the disease and more precise follow-ups and treatment in the early phases of the disease. |
| first_indexed | 2024-03-11T09:48:08Z |
| format | Article |
| id | doaj.art-6d285a8ba9994080b1ff9cdb857199e6 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T09:48:08Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-6d285a8ba9994080b1ff9cdb857199e62023-11-16T16:25:12ZengMDPI AGDiagnostics2075-44182023-01-0113347110.3390/diagnostics13030471Molecular Biomarkers in Perthes Disease: A ReviewVesna Spasovski0Sanja Srzentić Dražilov1Gordana Nikčević2Zoran Baščarević3Maja Stojiljković4Sonja Pavlović5Duško Spasovski6Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11010 Belgrade, SerbiaInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11010 Belgrade, SerbiaInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11010 Belgrade, SerbiaSchool of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, SerbiaInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11010 Belgrade, SerbiaInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11010 Belgrade, SerbiaSchool of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, SerbiaBackground: Perthes disease is a juvenile form of osteonecrosis of the femoral head that affects children under the age of 15. One hundred years after its discovery, some light has been shed on its etiology and the biological factors relevant to its etiology and disease severity. Methods: The aim of this study was to summarize the literature findings on the biological factors relevant to the pathogenesis of Perthes disease, their diagnostic and clinical significance, and their therapeutic potential. A special focus on candidate genes as susceptibility factors and factors relevant to clinical severity was made, where studies reporting clinical or preclinical results were considered as the inclusion criteria. PubMed databases were searched by two independent researchers. Sixty-eight articles were included in this review. Results on the factors relevant to vascular involvement and inflammatory molecules indicated as factors that contribute to impaired bone remodeling have been summarized. Moreover, several candidate genes relevant to an active phase of the disease have been suggested as possible biological therapeutic targets. Conclusions: Delineation of molecular biomarkers that underlie the pathophysiological process of Perthes disease can allow for the provision of earlier and more accurate diagnoses of the disease and more precise follow-ups and treatment in the early phases of the disease.https://www.mdpi.com/2075-4418/13/3/471Perthes diseasecandidate genesbiomarkersbiological therapy |
| spellingShingle | Vesna Spasovski Sanja Srzentić Dražilov Gordana Nikčević Zoran Baščarević Maja Stojiljković Sonja Pavlović Duško Spasovski Molecular Biomarkers in Perthes Disease: A Review Diagnostics Perthes disease candidate genes biomarkers biological therapy |
| title | Molecular Biomarkers in Perthes Disease: A Review |
| title_full | Molecular Biomarkers in Perthes Disease: A Review |
| title_fullStr | Molecular Biomarkers in Perthes Disease: A Review |
| title_full_unstemmed | Molecular Biomarkers in Perthes Disease: A Review |
| title_short | Molecular Biomarkers in Perthes Disease: A Review |
| title_sort | molecular biomarkers in perthes disease a review |
| topic | Perthes disease candidate genes biomarkers biological therapy |
| url | https://www.mdpi.com/2075-4418/13/3/471 |
| work_keys_str_mv | AT vesnaspasovski molecularbiomarkersinperthesdiseaseareview AT sanjasrzenticdrazilov molecularbiomarkersinperthesdiseaseareview AT gordananikcevic molecularbiomarkersinperthesdiseaseareview AT zoranbascarevic molecularbiomarkersinperthesdiseaseareview AT majastojiljkovic molecularbiomarkersinperthesdiseaseareview AT sonjapavlovic molecularbiomarkersinperthesdiseaseareview AT duskospasovski molecularbiomarkersinperthesdiseaseareview |