Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications
Polymeric membranes are good alternatives to conventional dressings for wound-healing applications, owing to their high porosity and surface area. Incorporation of bioactive particles into membranes can improve therapeutic outcomes of dressings. Curcumin has been reported as a bioactive particle wit...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Journal of Materials Research and Technology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2238785422004434 |
| _version_ | 1818188512755712000 |
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| author | Karla A. Barbosa Isabella C.P. Rodrigues Letícia Tamborlin Augusto D. Luchessi Éder S.N. Lopes Laís P. Gabriel |
| author_facet | Karla A. Barbosa Isabella C.P. Rodrigues Letícia Tamborlin Augusto D. Luchessi Éder S.N. Lopes Laís P. Gabriel |
| author_sort | Karla A. Barbosa |
| collection | DOAJ |
| description | Polymeric membranes are good alternatives to conventional dressings for wound-healing applications, owing to their high porosity and surface area. Incorporation of bioactive particles into membranes can improve therapeutic outcomes of dressings. Curcumin has been reported as a bioactive particle with antioxidant and wound-healing potential, as well as therapeutic action against diabetes, inflammation, and cancer. However, few techniques have been explored to efficiently produce curcumin-incorporated dressings on a large scale. Rotary jet spinning (RJS) is a membrane processing technique that has gained attention for its high production rate of fibers. In this study, we aimed to produce and characterize poly(L-lactic acid) (PLLA)-based RJS membranes incorporated with curcumin particles (PLLA-Curc) for wound-treatment suitability. We produced membranes with fiber diameters less than 10 μm. The membranes demonstrated thermal stability, a hydrophobic profile, adequate mechanical resistance for topical application, low degradation rates, and a marked release of curcumin over 6 h, followed by a continuous–release profile. In addition, PLLA and PLLA-Curc membranes showed cytocompatibility with fibroblasts. In summary, RJS is an efficient technique to obtain membranes incorporated with curcumin that have potential for wound treatment as non-adherent topical dressings. |
| first_indexed | 2024-12-11T23:28:06Z |
| format | Article |
| id | doaj.art-6d28cc2c35f04064b234b67e3ef070f9 |
| institution | Directory Open Access Journal |
| issn | 2238-7854 |
| language | English |
| last_indexed | 2024-12-11T23:28:06Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Materials Research and Technology |
| spelling | doaj.art-6d28cc2c35f04064b234b67e3ef070f92022-12-22T00:46:08ZengElsevierJournal of Materials Research and Technology2238-78542022-05-011832733282Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applicationsKarla A. Barbosa0Isabella C.P. Rodrigues1Letícia Tamborlin2Augusto D. Luchessi3Éder S.N. Lopes4Laís P. Gabriel5School of Applied Sciences, University of Campinas, Limeira, São Paulo, BrazilSchool of Mechanical Engineering, University of Campinas, Campinas, São Paulo, BrazilSchool of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil; Institute of Biosciences, São Paulo State University, Rio Claro, São Paulo, BrazilSchool of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil; Institute of Biosciences, São Paulo State University, Rio Claro, São Paulo, BrazilSchool of Mechanical Engineering, University of Campinas, Campinas, São Paulo, BrazilSchool of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil; Corresponding author.Polymeric membranes are good alternatives to conventional dressings for wound-healing applications, owing to their high porosity and surface area. Incorporation of bioactive particles into membranes can improve therapeutic outcomes of dressings. Curcumin has been reported as a bioactive particle with antioxidant and wound-healing potential, as well as therapeutic action against diabetes, inflammation, and cancer. However, few techniques have been explored to efficiently produce curcumin-incorporated dressings on a large scale. Rotary jet spinning (RJS) is a membrane processing technique that has gained attention for its high production rate of fibers. In this study, we aimed to produce and characterize poly(L-lactic acid) (PLLA)-based RJS membranes incorporated with curcumin particles (PLLA-Curc) for wound-treatment suitability. We produced membranes with fiber diameters less than 10 μm. The membranes demonstrated thermal stability, a hydrophobic profile, adequate mechanical resistance for topical application, low degradation rates, and a marked release of curcumin over 6 h, followed by a continuous–release profile. In addition, PLLA and PLLA-Curc membranes showed cytocompatibility with fibroblasts. In summary, RJS is an efficient technique to obtain membranes incorporated with curcumin that have potential for wound treatment as non-adherent topical dressings.http://www.sciencedirect.com/science/article/pii/S2238785422004434Centrifugal spinningDrug releasePolylactic acidScaffoldWound dressing |
| spellingShingle | Karla A. Barbosa Isabella C.P. Rodrigues Letícia Tamborlin Augusto D. Luchessi Éder S.N. Lopes Laís P. Gabriel Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications Journal of Materials Research and Technology Centrifugal spinning Drug release Polylactic acid Scaffold Wound dressing |
| title | Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications |
| title_full | Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications |
| title_fullStr | Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications |
| title_full_unstemmed | Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications |
| title_short | Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications |
| title_sort | rotary jet spun curcumin loaded poly l lactic acid membranes for wound healing applications |
| topic | Centrifugal spinning Drug release Polylactic acid Scaffold Wound dressing |
| url | http://www.sciencedirect.com/science/article/pii/S2238785422004434 |
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