Non-invasive Vagus Nerve Simulation in Postural Orthostatic Tachycardia Syndrome
Postural orthostatic tachycardia syndrome (POTS) is a chronic debilitating condition of orthostatic intolerance, predominantly affecting young females. Other than postural tachycardia, symptoms of POTS include a spectrum of non-cardiac, systemic and neuropsychiatric features. Despite the availabilit...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Radcliffe Medical Media
2023-12-01
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| Series: | Arrhythmia & Electrophysiology Review |
| Online Access: | https://www.aerjournal.com/articleindex/aer.2023.20 |
| _version_ | 1797199986291638272 |
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| author | Praloy Chakraborty Kassem Farhat Lynsie Morris Seabrook Whyte Xichun Yu Stavros Stavrakis |
| author_facet | Praloy Chakraborty Kassem Farhat Lynsie Morris Seabrook Whyte Xichun Yu Stavros Stavrakis |
| author_sort | Praloy Chakraborty |
| collection | DOAJ |
| description | Postural orthostatic tachycardia syndrome (POTS) is a chronic debilitating condition of orthostatic intolerance, predominantly affecting young females. Other than postural tachycardia, symptoms of POTS include a spectrum of non-cardiac, systemic and neuropsychiatric features. Despite the availability of widespread pharmacological and non-pharmacological therapeutic options, the management of POTS remains challenging. Exaggerated parasympathetic withdrawal and sympathetic overdrive during postural stress are principal mechanisms of postural tachycardia in POTS. Non-invasive, transcutaneous, vagus nerve stimulation (tVNS) is known to restore sympathovagal balance and is emerging as a novel therapeutic strategy in cardiovascular conditions including arrhythmias and heart failure. Furthermore, tVNS also exerts immunomodulatory and anti-inflammatory effects. This review explores the effects of tVNS on the pathophysiology of POTS and its potential as an alternative non-pharmacological option in this condition. |
| first_indexed | 2024-03-07T17:39:00Z |
| format | Article |
| id | doaj.art-6d28fed7a6f34f109e9507f1e1dd2ad7 |
| institution | Directory Open Access Journal |
| issn | 2050-3369 2050-3377 |
| language | English |
| last_indexed | 2024-04-24T07:24:28Z |
| publishDate | 2023-12-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | Arrhythmia & Electrophysiology Review |
| spelling | doaj.art-6d28fed7a6f34f109e9507f1e1dd2ad72024-04-20T16:03:47ZengRadcliffe Medical MediaArrhythmia & Electrophysiology Review2050-33692050-33772023-12-011210.15420/aer.2023.20Non-invasive Vagus Nerve Simulation in Postural Orthostatic Tachycardia SyndromePraloy Chakraborty0Kassem Farhat1Lynsie Morris2Seabrook Whyte3Xichun Yu4Stavros Stavrakis5Heart Rhythm Institute, University of Oklahoma Health and Sciences Center, Oklahoma City, OK, USHeart Rhythm Institute, University of Oklahoma Health and Sciences Center, Oklahoma City, OK, USHeart Rhythm Institute, University of Oklahoma Health and Sciences Center, Oklahoma City, OK, USHeart Rhythm Institute, University of Oklahoma Health and Sciences Center, Oklahoma City, OK, USHeart Rhythm Institute, University of Oklahoma Health and Sciences Center, Oklahoma City, OK, USHeart Rhythm Institute, University of Oklahoma Health and Sciences Center, Oklahoma City, OK, USPostural orthostatic tachycardia syndrome (POTS) is a chronic debilitating condition of orthostatic intolerance, predominantly affecting young females. Other than postural tachycardia, symptoms of POTS include a spectrum of non-cardiac, systemic and neuropsychiatric features. Despite the availability of widespread pharmacological and non-pharmacological therapeutic options, the management of POTS remains challenging. Exaggerated parasympathetic withdrawal and sympathetic overdrive during postural stress are principal mechanisms of postural tachycardia in POTS. Non-invasive, transcutaneous, vagus nerve stimulation (tVNS) is known to restore sympathovagal balance and is emerging as a novel therapeutic strategy in cardiovascular conditions including arrhythmias and heart failure. Furthermore, tVNS also exerts immunomodulatory and anti-inflammatory effects. This review explores the effects of tVNS on the pathophysiology of POTS and its potential as an alternative non-pharmacological option in this condition.https://www.aerjournal.com/articleindex/aer.2023.20 |
| spellingShingle | Praloy Chakraborty Kassem Farhat Lynsie Morris Seabrook Whyte Xichun Yu Stavros Stavrakis Non-invasive Vagus Nerve Simulation in Postural Orthostatic Tachycardia Syndrome Arrhythmia & Electrophysiology Review |
| title | Non-invasive Vagus Nerve Simulation in Postural Orthostatic Tachycardia Syndrome |
| title_full | Non-invasive Vagus Nerve Simulation in Postural Orthostatic Tachycardia Syndrome |
| title_fullStr | Non-invasive Vagus Nerve Simulation in Postural Orthostatic Tachycardia Syndrome |
| title_full_unstemmed | Non-invasive Vagus Nerve Simulation in Postural Orthostatic Tachycardia Syndrome |
| title_short | Non-invasive Vagus Nerve Simulation in Postural Orthostatic Tachycardia Syndrome |
| title_sort | non invasive vagus nerve simulation in postural orthostatic tachycardia syndrome |
| url | https://www.aerjournal.com/articleindex/aer.2023.20 |
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