Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus
As obligate intracellular pathogens, viruses depend on the host cell machinery to complete their life cycle. Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic virus causally linked to the development of Kaposi’s sarcoma and several other lymphoproliferative malignancies. KSHV entry into...
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-10-01
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| Series: | Pathogens |
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| Online Access: | http://www.mdpi.com/2076-0817/1/2/102 |
| _version_ | 1798039859962576896 |
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| author | Wei Zhang Shou-Jiang Gao |
| author_facet | Wei Zhang Shou-Jiang Gao |
| author_sort | Wei Zhang |
| collection | DOAJ |
| description | As obligate intracellular pathogens, viruses depend on the host cell machinery to complete their life cycle. Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic virus causally linked to the development of Kaposi’s sarcoma and several other lymphoproliferative malignancies. KSHV entry into cells is tightly regulated by diverse viral and cellular factors. In particular, KSHV actively engages cellular integrins and ubiquitination pathways for successful infection. Emerging evidence suggests that KSHV hijacks both actin and microtubule cytoskeletons at different phases during entry into cells. Here, we review recent findings on the early events during primary infection of KSHV and its closely related primate homolog rhesus rhadinovirus with highlights on the regulation of cellular cytoskeletons and signaling pathways that are important for this phase of virus life cycle. |
| first_indexed | 2024-04-11T21:59:30Z |
| format | Article |
| id | doaj.art-6d2c227dcaa84dc2bb077a8f07837148 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-04-11T21:59:30Z |
| publishDate | 2012-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-6d2c227dcaa84dc2bb077a8f078371482022-12-22T04:00:59ZengMDPI AGPathogens2076-08172012-10-011210212710.3390/pathogens1020102Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus RhadinovirusWei ZhangShou-Jiang GaoAs obligate intracellular pathogens, viruses depend on the host cell machinery to complete their life cycle. Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic virus causally linked to the development of Kaposi’s sarcoma and several other lymphoproliferative malignancies. KSHV entry into cells is tightly regulated by diverse viral and cellular factors. In particular, KSHV actively engages cellular integrins and ubiquitination pathways for successful infection. Emerging evidence suggests that KSHV hijacks both actin and microtubule cytoskeletons at different phases during entry into cells. Here, we review recent findings on the early events during primary infection of KSHV and its closely related primate homolog rhesus rhadinovirus with highlights on the regulation of cellular cytoskeletons and signaling pathways that are important for this phase of virus life cycle.http://www.mdpi.com/2076-0817/1/2/102Kaposi’s Sarcoma-Associated Herpesvirus (KSHV)Rhesus Rhadinovirus (RRV)virus entryendocytosisactinmicrotubuleintegrincellular signalingubiquitination |
| spellingShingle | Wei Zhang Shou-Jiang Gao Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus Pathogens Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) Rhesus Rhadinovirus (RRV) virus entry endocytosis actin microtubule integrin cellular signaling ubiquitination |
| title | Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus |
| title_full | Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus |
| title_fullStr | Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus |
| title_full_unstemmed | Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus |
| title_short | Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus |
| title_sort | exploitation of cellular cytoskeletons and signaling pathways for cell entry by kaposi s sarcoma associated herpesvirus and the closely related rhesus rhadinovirus |
| topic | Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) Rhesus Rhadinovirus (RRV) virus entry endocytosis actin microtubule integrin cellular signaling ubiquitination |
| url | http://www.mdpi.com/2076-0817/1/2/102 |
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