State-of-the-art polymeric nanoparticles as promising therapeutic tools against human bacterial infections
Abstract Infectious diseases kill over 17 million people a year, among which bacterial infections stand out. From all the bacterial infections, tuberculosis, diarrhoea, meningitis, pneumonia, sexual transmission diseases and nosocomial infections are the most severe bacterial infections, which affec...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12951-020-00714-2 |
| _version_ | 1828117467518468096 |
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| author | Amanda Cano Miren Ettcheto Marta Espina Ana López-Machado Yolanda Cajal Francesc Rabanal Elena Sánchez-López Antonio Camins Maria Luisa García Eliana B. Souto |
| author_facet | Amanda Cano Miren Ettcheto Marta Espina Ana López-Machado Yolanda Cajal Francesc Rabanal Elena Sánchez-López Antonio Camins Maria Luisa García Eliana B. Souto |
| author_sort | Amanda Cano |
| collection | DOAJ |
| description | Abstract Infectious diseases kill over 17 million people a year, among which bacterial infections stand out. From all the bacterial infections, tuberculosis, diarrhoea, meningitis, pneumonia, sexual transmission diseases and nosocomial infections are the most severe bacterial infections, which affect millions of people worldwide. Moreover, the indiscriminate use of antibiotic drugs in the last decades has triggered an increasing multiple resistance towards these drugs, which represent a serious global socioeconomic and public health risk. It is estimated that 33,000 and 35,000 people die yearly in Europe and the United States, respectively, as a direct result of antimicrobial resistance. For all these reasons, there is an emerging need to find novel alternatives to overcome these issues and reduced the morbidity and mortality associated to bacterial infectious diseases. In that sense, nanotechnological approaches, especially smart polymeric nanoparticles, has wrought a revolution in this field, providing an innovative therapeutic alternative able to improve the limitations encountered in available treatments and capable to be effective by theirselves. In this review, we examine the current status of most dangerous human infections, together with an in-depth discussion of the role of nanomedicine to overcome the current disadvantages, and specifically the most recent and innovative studies involving polymeric nanoparticles against most common bacterial infections of the human body. |
| first_indexed | 2024-04-11T13:14:46Z |
| format | Article |
| id | doaj.art-6d2c23ee397842dbb660bd7d10de5e58 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T13:14:46Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-6d2c23ee397842dbb660bd7d10de5e582022-12-22T04:22:25ZengBMCJournal of Nanobiotechnology1477-31552020-10-0118112410.1186/s12951-020-00714-2State-of-the-art polymeric nanoparticles as promising therapeutic tools against human bacterial infectionsAmanda Cano0Miren Ettcheto1Marta Espina2Ana López-Machado3Yolanda Cajal4Francesc Rabanal5Elena Sánchez-López6Antonio Camins7Maria Luisa García8Eliana B. Souto9Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of BarcelonaBiomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED)Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of BarcelonaDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of BarcelonaDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of BarcelonaSection of Organic Chemistry, Department of Inorganic and Organic Chemistry, Faculty of Chemistry, University of BarcelonaDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of BarcelonaBiomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED)Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of BarcelonaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of CoimbraAbstract Infectious diseases kill over 17 million people a year, among which bacterial infections stand out. From all the bacterial infections, tuberculosis, diarrhoea, meningitis, pneumonia, sexual transmission diseases and nosocomial infections are the most severe bacterial infections, which affect millions of people worldwide. Moreover, the indiscriminate use of antibiotic drugs in the last decades has triggered an increasing multiple resistance towards these drugs, which represent a serious global socioeconomic and public health risk. It is estimated that 33,000 and 35,000 people die yearly in Europe and the United States, respectively, as a direct result of antimicrobial resistance. For all these reasons, there is an emerging need to find novel alternatives to overcome these issues and reduced the morbidity and mortality associated to bacterial infectious diseases. In that sense, nanotechnological approaches, especially smart polymeric nanoparticles, has wrought a revolution in this field, providing an innovative therapeutic alternative able to improve the limitations encountered in available treatments and capable to be effective by theirselves. In this review, we examine the current status of most dangerous human infections, together with an in-depth discussion of the role of nanomedicine to overcome the current disadvantages, and specifically the most recent and innovative studies involving polymeric nanoparticles against most common bacterial infections of the human body.http://link.springer.com/article/10.1186/s12951-020-00714-2Bacterial infectionsInfectious diseasesPolymeric nanoparticlesNanomedicineNanotechnology |
| spellingShingle | Amanda Cano Miren Ettcheto Marta Espina Ana López-Machado Yolanda Cajal Francesc Rabanal Elena Sánchez-López Antonio Camins Maria Luisa García Eliana B. Souto State-of-the-art polymeric nanoparticles as promising therapeutic tools against human bacterial infections Journal of Nanobiotechnology Bacterial infections Infectious diseases Polymeric nanoparticles Nanomedicine Nanotechnology |
| title | State-of-the-art polymeric nanoparticles as promising therapeutic tools against human bacterial infections |
| title_full | State-of-the-art polymeric nanoparticles as promising therapeutic tools against human bacterial infections |
| title_fullStr | State-of-the-art polymeric nanoparticles as promising therapeutic tools against human bacterial infections |
| title_full_unstemmed | State-of-the-art polymeric nanoparticles as promising therapeutic tools against human bacterial infections |
| title_short | State-of-the-art polymeric nanoparticles as promising therapeutic tools against human bacterial infections |
| title_sort | state of the art polymeric nanoparticles as promising therapeutic tools against human bacterial infections |
| topic | Bacterial infections Infectious diseases Polymeric nanoparticles Nanomedicine Nanotechnology |
| url | http://link.springer.com/article/10.1186/s12951-020-00714-2 |
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