Genomic analysis and prediction of genomic values for distichiasis in Staffordshire bull terriers
Abstract Background Distichiasis is a condition characterized by aberrant hairs along the eyelid margins. The symptoms are usually mild but can lead to ulcerations and lesions of the cornea in severe cases. It is the most frequently noted ocular disorder in Norwegian Staffordshire bull terriers (SBT...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-07-01
|
| Series: | Canine Medicine and Genetics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40575-023-00132-1 |
| _version_ | 1797769439036309504 |
|---|---|
| author | Dina Jørgensen Ernst-Otto Ropstad Theodorus Meuwissen Frode Lingaas |
| author_facet | Dina Jørgensen Ernst-Otto Ropstad Theodorus Meuwissen Frode Lingaas |
| author_sort | Dina Jørgensen |
| collection | DOAJ |
| description | Abstract Background Distichiasis is a condition characterized by aberrant hairs along the eyelid margins. The symptoms are usually mild but can lead to ulcerations and lesions of the cornea in severe cases. It is the most frequently noted ocular disorder in Norwegian Staffordshire bull terriers (SBT), with a prevalence above 18% in the adult population. A complex inheritance is assumed, but there is sparse knowledge about the genetic background of distichiasis in dogs. We have performed a genome-wide association study of distichiasis in SBT and used genomic data in an attempt to predict genomic values for the disorder. Results We identified four genetic regions on CFA1, CFA18, CFA32 and CFA34 using a mixed linear model association analysis and a Bayesian mixed model analysis. Genomic values were predicted using GBLUP and a Bayesian approach, BayesR. The genomic prediction showed that the 1/4 of dogs with predicted values most likely to acquire distichiasis had a 3.9 -4.0 times higher risk of developing distichiasis compared to the quarter (1/4) of dogs least likely to acquire the disease. There was no significant difference between the two methods used. Conclusion Four genomic regions associated with distichiasis were discovered in the association analysis, suggesting that distichiasis in SBT is a complex trait involving numerous loci. The four associated regions need to be confirmed in an independent sample. We also used all 95 K SNPs for genomic prediction and showed that genomic prediction can be a helpful tool in selective breeding schemes at breed level aiming at reducing the prevalence of distichiasis in SBTs in the future, even if the predictive value of single dogs may be low. |
| first_indexed | 2024-03-12T21:09:01Z |
| format | Article |
| id | doaj.art-6d2e8422011e47ac9162214e9f5f59a5 |
| institution | Directory Open Access Journal |
| issn | 2662-9380 |
| language | English |
| last_indexed | 2024-03-12T21:09:01Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Canine Medicine and Genetics |
| spelling | doaj.art-6d2e8422011e47ac9162214e9f5f59a52023-07-30T11:17:22ZengBMCCanine Medicine and Genetics2662-93802023-07-0110111010.1186/s40575-023-00132-1Genomic analysis and prediction of genomic values for distichiasis in Staffordshire bull terriersDina Jørgensen0Ernst-Otto Ropstad1Theodorus Meuwissen2Frode Lingaas3Medical Genetics Unit, Faculty of Veterinary Medicine, Norwegian University of Life SciencesEvidensia Oslo DyresykehusDepartment of Animal and Aquacultural Sciences, Faculty of Biosciences, Norwegian University of Life SciencesMedical Genetics Unit, Faculty of Veterinary Medicine, Norwegian University of Life SciencesAbstract Background Distichiasis is a condition characterized by aberrant hairs along the eyelid margins. The symptoms are usually mild but can lead to ulcerations and lesions of the cornea in severe cases. It is the most frequently noted ocular disorder in Norwegian Staffordshire bull terriers (SBT), with a prevalence above 18% in the adult population. A complex inheritance is assumed, but there is sparse knowledge about the genetic background of distichiasis in dogs. We have performed a genome-wide association study of distichiasis in SBT and used genomic data in an attempt to predict genomic values for the disorder. Results We identified four genetic regions on CFA1, CFA18, CFA32 and CFA34 using a mixed linear model association analysis and a Bayesian mixed model analysis. Genomic values were predicted using GBLUP and a Bayesian approach, BayesR. The genomic prediction showed that the 1/4 of dogs with predicted values most likely to acquire distichiasis had a 3.9 -4.0 times higher risk of developing distichiasis compared to the quarter (1/4) of dogs least likely to acquire the disease. There was no significant difference between the two methods used. Conclusion Four genomic regions associated with distichiasis were discovered in the association analysis, suggesting that distichiasis in SBT is a complex trait involving numerous loci. The four associated regions need to be confirmed in an independent sample. We also used all 95 K SNPs for genomic prediction and showed that genomic prediction can be a helpful tool in selective breeding schemes at breed level aiming at reducing the prevalence of distichiasis in SBTs in the future, even if the predictive value of single dogs may be low.https://doi.org/10.1186/s40575-023-00132-1CanineGenomic predictionDistichiasisGWASStaffordshire bull terrier |
| spellingShingle | Dina Jørgensen Ernst-Otto Ropstad Theodorus Meuwissen Frode Lingaas Genomic analysis and prediction of genomic values for distichiasis in Staffordshire bull terriers Canine Medicine and Genetics Canine Genomic prediction Distichiasis GWAS Staffordshire bull terrier |
| title | Genomic analysis and prediction of genomic values for distichiasis in Staffordshire bull terriers |
| title_full | Genomic analysis and prediction of genomic values for distichiasis in Staffordshire bull terriers |
| title_fullStr | Genomic analysis and prediction of genomic values for distichiasis in Staffordshire bull terriers |
| title_full_unstemmed | Genomic analysis and prediction of genomic values for distichiasis in Staffordshire bull terriers |
| title_short | Genomic analysis and prediction of genomic values for distichiasis in Staffordshire bull terriers |
| title_sort | genomic analysis and prediction of genomic values for distichiasis in staffordshire bull terriers |
| topic | Canine Genomic prediction Distichiasis GWAS Staffordshire bull terrier |
| url | https://doi.org/10.1186/s40575-023-00132-1 |
| work_keys_str_mv | AT dinajørgensen genomicanalysisandpredictionofgenomicvaluesfordistichiasisinstaffordshirebullterriers AT ernstottoropstad genomicanalysisandpredictionofgenomicvaluesfordistichiasisinstaffordshirebullterriers AT theodorusmeuwissen genomicanalysisandpredictionofgenomicvaluesfordistichiasisinstaffordshirebullterriers AT frodelingaas genomicanalysisandpredictionofgenomicvaluesfordistichiasisinstaffordshirebullterriers |