Human neonatal dendritic cells are competent in MHC class I antigen processing and presentation.
Neonates are clearly more susceptible to severe disease following infection with a variety of pathogens than are adults. However, the causes for this are unclear and are often attributed to immunological immaturity. While several aspects of immunity differ between adults and neonates, the capacity o...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2007-09-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC1978526?pdf=render |
| _version_ | 1818994434830761984 |
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| author | Marielle C Gold Tammie L Robinson Matthew S Cook Laura K Byrd Heather D Ehlinger David M Lewinsohn Deborah A Lewinsohn |
| author_facet | Marielle C Gold Tammie L Robinson Matthew S Cook Laura K Byrd Heather D Ehlinger David M Lewinsohn Deborah A Lewinsohn |
| author_sort | Marielle C Gold |
| collection | DOAJ |
| description | Neonates are clearly more susceptible to severe disease following infection with a variety of pathogens than are adults. However, the causes for this are unclear and are often attributed to immunological immaturity. While several aspects of immunity differ between adults and neonates, the capacity of dendritic cells in neonates to process and present antigen to CD8+ T cells remains to be addressed. We used human CD8+ T cell clones to compare the ability of neonatal and adult monocyte-derived dendritic cells to present or process and present antigen using the MHC class I pathway. Specifically, we assessed the ability of dendritic cells to present antigenic peptide, present an HLA-E-restricted antigen, process and present an MHC class I-restricted antigen through the classical MHC class I pathway, and cross present cell-associated antigen via MHC class I. We found no defect in neonatal dendritic cells to perform any of these processing and presentation functions and conclude that the MHC class I antigen processing and presentation pathway is functional in neonatal dendritic cells and hence may not account for the diminished control of pathogens. |
| first_indexed | 2024-12-20T20:57:54Z |
| format | Article |
| id | doaj.art-6d2ecdbd9d1b4af2bd09acc616e3343d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T20:57:54Z |
| publishDate | 2007-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6d2ecdbd9d1b4af2bd09acc616e3343d2022-12-21T19:26:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032007-09-0129e95710.1371/journal.pone.0000957Human neonatal dendritic cells are competent in MHC class I antigen processing and presentation.Marielle C GoldTammie L RobinsonMatthew S CookLaura K ByrdHeather D EhlingerDavid M LewinsohnDeborah A LewinsohnNeonates are clearly more susceptible to severe disease following infection with a variety of pathogens than are adults. However, the causes for this are unclear and are often attributed to immunological immaturity. While several aspects of immunity differ between adults and neonates, the capacity of dendritic cells in neonates to process and present antigen to CD8+ T cells remains to be addressed. We used human CD8+ T cell clones to compare the ability of neonatal and adult monocyte-derived dendritic cells to present or process and present antigen using the MHC class I pathway. Specifically, we assessed the ability of dendritic cells to present antigenic peptide, present an HLA-E-restricted antigen, process and present an MHC class I-restricted antigen through the classical MHC class I pathway, and cross present cell-associated antigen via MHC class I. We found no defect in neonatal dendritic cells to perform any of these processing and presentation functions and conclude that the MHC class I antigen processing and presentation pathway is functional in neonatal dendritic cells and hence may not account for the diminished control of pathogens.http://europepmc.org/articles/PMC1978526?pdf=render |
| spellingShingle | Marielle C Gold Tammie L Robinson Matthew S Cook Laura K Byrd Heather D Ehlinger David M Lewinsohn Deborah A Lewinsohn Human neonatal dendritic cells are competent in MHC class I antigen processing and presentation. PLoS ONE |
| title | Human neonatal dendritic cells are competent in MHC class I antigen processing and presentation. |
| title_full | Human neonatal dendritic cells are competent in MHC class I antigen processing and presentation. |
| title_fullStr | Human neonatal dendritic cells are competent in MHC class I antigen processing and presentation. |
| title_full_unstemmed | Human neonatal dendritic cells are competent in MHC class I antigen processing and presentation. |
| title_short | Human neonatal dendritic cells are competent in MHC class I antigen processing and presentation. |
| title_sort | human neonatal dendritic cells are competent in mhc class i antigen processing and presentation |
| url | http://europepmc.org/articles/PMC1978526?pdf=render |
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