Persistent complete molecular remission after nilotinib and graft-versus-leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantation
<p>Abstract</p> <p>We report the successful treatment and sustained molecular remission using single agent nilotinib in a relapsed Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia patient after allogeneic hematopoietic stem cell transplantation. Compared to previ...
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Format: | Article |
Language: | English |
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BMC
2012-09-01
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Series: | Experimental Hematology & Oncology |
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Online Access: | http://www.ehoonline.org/content/1/1/29 |
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author | Farnsworth Paul Ward David Reddy Vijay |
author_facet | Farnsworth Paul Ward David Reddy Vijay |
author_sort | Farnsworth Paul |
collection | DOAJ |
description | <p>Abstract</p> <p>We report the successful treatment and sustained molecular remission using single agent nilotinib in a relapsed Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia patient after allogeneic hematopoietic stem cell transplantation. Compared to previously published studies, this is the first report where a patient did not receive additional chemotherapy after relapse, nor did she receive donor lymphocyte infusions. With nilotinib, the patient reverted back to normal blood counts and 100% donor reconstitution by single tandem repeat (STR) chimerism analysis in the bone marrow and in peripheral blood, granulocytes, T and B-lymphocytes. This report also highlights the use of nilotinib in combination with extracorporeal photopheresis (ECP) for concomitant graft-versus-host disease. Our data suggests that ECP, together with nilotinib, did not adversely affect the overall Graft-versus-leukemia (GVL) effect.</p> |
first_indexed | 2024-04-13T15:55:19Z |
format | Article |
id | doaj.art-6d319e38146d404eae5a3e8b6329f71e |
institution | Directory Open Access Journal |
issn | 2162-3619 |
language | English |
last_indexed | 2024-04-13T15:55:19Z |
publishDate | 2012-09-01 |
publisher | BMC |
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series | Experimental Hematology & Oncology |
spelling | doaj.art-6d319e38146d404eae5a3e8b6329f71e2022-12-22T02:40:43ZengBMCExperimental Hematology & Oncology2162-36192012-09-01112910.1186/2162-3619-1-29Persistent complete molecular remission after nilotinib and graft-versus-leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantationFarnsworth PaulWard DavidReddy Vijay<p>Abstract</p> <p>We report the successful treatment and sustained molecular remission using single agent nilotinib in a relapsed Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia patient after allogeneic hematopoietic stem cell transplantation. Compared to previously published studies, this is the first report where a patient did not receive additional chemotherapy after relapse, nor did she receive donor lymphocyte infusions. With nilotinib, the patient reverted back to normal blood counts and 100% donor reconstitution by single tandem repeat (STR) chimerism analysis in the bone marrow and in peripheral blood, granulocytes, T and B-lymphocytes. This report also highlights the use of nilotinib in combination with extracorporeal photopheresis (ECP) for concomitant graft-versus-host disease. Our data suggests that ECP, together with nilotinib, did not adversely affect the overall Graft-versus-leukemia (GVL) effect.</p>http://www.ehoonline.org/content/1/1/29Philadelphia chromosome positive acute lymphoblastic leukemia (PH + ALL)NilotinibExtracorporeal photopheresis (ECP)Graft-versus-host disease (GVHD)Graft-versus-leukemia effect (GVL)Hematopoietic stem cell transplantation (HSCT) |
spellingShingle | Farnsworth Paul Ward David Reddy Vijay Persistent complete molecular remission after nilotinib and graft-versus-leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantation Experimental Hematology & Oncology Philadelphia chromosome positive acute lymphoblastic leukemia (PH + ALL) Nilotinib Extracorporeal photopheresis (ECP) Graft-versus-host disease (GVHD) Graft-versus-leukemia effect (GVL) Hematopoietic stem cell transplantation (HSCT) |
title | Persistent complete molecular remission after nilotinib and graft-versus-leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantation |
title_full | Persistent complete molecular remission after nilotinib and graft-versus-leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantation |
title_fullStr | Persistent complete molecular remission after nilotinib and graft-versus-leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantation |
title_full_unstemmed | Persistent complete molecular remission after nilotinib and graft-versus-leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantation |
title_short | Persistent complete molecular remission after nilotinib and graft-versus-leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantation |
title_sort | persistent complete molecular remission after nilotinib and graft versus leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantation |
topic | Philadelphia chromosome positive acute lymphoblastic leukemia (PH + ALL) Nilotinib Extracorporeal photopheresis (ECP) Graft-versus-host disease (GVHD) Graft-versus-leukemia effect (GVL) Hematopoietic stem cell transplantation (HSCT) |
url | http://www.ehoonline.org/content/1/1/29 |
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