Persistent complete molecular remission after nilotinib and graft-versus-leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantation
<p>Abstract</p> <p>We report the successful treatment and sustained molecular remission using single agent nilotinib in a relapsed Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia patient after allogeneic hematopoietic stem cell transplantation. Compared to previ...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-09-01
|
| Series: | Experimental Hematology & Oncology |
| Subjects: | |
| Online Access: | http://www.ehoonline.org/content/1/1/29 |
| _version_ | 1811330080135184384 |
|---|---|
| author | Farnsworth Paul Ward David Reddy Vijay |
| author_facet | Farnsworth Paul Ward David Reddy Vijay |
| author_sort | Farnsworth Paul |
| collection | DOAJ |
| description | <p>Abstract</p> <p>We report the successful treatment and sustained molecular remission using single agent nilotinib in a relapsed Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia patient after allogeneic hematopoietic stem cell transplantation. Compared to previously published studies, this is the first report where a patient did not receive additional chemotherapy after relapse, nor did she receive donor lymphocyte infusions. With nilotinib, the patient reverted back to normal blood counts and 100% donor reconstitution by single tandem repeat (STR) chimerism analysis in the bone marrow and in peripheral blood, granulocytes, T and B-lymphocytes. This report also highlights the use of nilotinib in combination with extracorporeal photopheresis (ECP) for concomitant graft-versus-host disease. Our data suggests that ECP, together with nilotinib, did not adversely affect the overall Graft-versus-leukemia (GVL) effect.</p> |
| first_indexed | 2024-04-13T15:55:19Z |
| format | Article |
| id | doaj.art-6d319e38146d404eae5a3e8b6329f71e |
| institution | Directory Open Access Journal |
| issn | 2162-3619 |
| language | English |
| last_indexed | 2024-04-13T15:55:19Z |
| publishDate | 2012-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Experimental Hematology & Oncology |
| spelling | doaj.art-6d319e38146d404eae5a3e8b6329f71e2022-12-22T02:40:43ZengBMCExperimental Hematology & Oncology2162-36192012-09-01112910.1186/2162-3619-1-29Persistent complete molecular remission after nilotinib and graft-versus-leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantationFarnsworth PaulWard DavidReddy Vijay<p>Abstract</p> <p>We report the successful treatment and sustained molecular remission using single agent nilotinib in a relapsed Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia patient after allogeneic hematopoietic stem cell transplantation. Compared to previously published studies, this is the first report where a patient did not receive additional chemotherapy after relapse, nor did she receive donor lymphocyte infusions. With nilotinib, the patient reverted back to normal blood counts and 100% donor reconstitution by single tandem repeat (STR) chimerism analysis in the bone marrow and in peripheral blood, granulocytes, T and B-lymphocytes. This report also highlights the use of nilotinib in combination with extracorporeal photopheresis (ECP) for concomitant graft-versus-host disease. Our data suggests that ECP, together with nilotinib, did not adversely affect the overall Graft-versus-leukemia (GVL) effect.</p>http://www.ehoonline.org/content/1/1/29Philadelphia chromosome positive acute lymphoblastic leukemia (PH + ALL)NilotinibExtracorporeal photopheresis (ECP)Graft-versus-host disease (GVHD)Graft-versus-leukemia effect (GVL)Hematopoietic stem cell transplantation (HSCT) |
| spellingShingle | Farnsworth Paul Ward David Reddy Vijay Persistent complete molecular remission after nilotinib and graft-versus-leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantation Experimental Hematology & Oncology Philadelphia chromosome positive acute lymphoblastic leukemia (PH + ALL) Nilotinib Extracorporeal photopheresis (ECP) Graft-versus-host disease (GVHD) Graft-versus-leukemia effect (GVL) Hematopoietic stem cell transplantation (HSCT) |
| title | Persistent complete molecular remission after nilotinib and graft-versus-leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantation |
| title_full | Persistent complete molecular remission after nilotinib and graft-versus-leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantation |
| title_fullStr | Persistent complete molecular remission after nilotinib and graft-versus-leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantation |
| title_full_unstemmed | Persistent complete molecular remission after nilotinib and graft-versus-leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantation |
| title_short | Persistent complete molecular remission after nilotinib and graft-versus-leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantation |
| title_sort | persistent complete molecular remission after nilotinib and graft versus leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantation |
| topic | Philadelphia chromosome positive acute lymphoblastic leukemia (PH + ALL) Nilotinib Extracorporeal photopheresis (ECP) Graft-versus-host disease (GVHD) Graft-versus-leukemia effect (GVL) Hematopoietic stem cell transplantation (HSCT) |
| url | http://www.ehoonline.org/content/1/1/29 |
| work_keys_str_mv | AT farnsworthpaul persistentcompletemolecularremissionafternilotinibandgraftversusleukemiaeffectinanacutelymphoblasticleukemiapatientwithcytogeneticrelapseafterallogeneicstemcelltransplantation AT warddavid persistentcompletemolecularremissionafternilotinibandgraftversusleukemiaeffectinanacutelymphoblasticleukemiapatientwithcytogeneticrelapseafterallogeneicstemcelltransplantation AT reddyvijay persistentcompletemolecularremissionafternilotinibandgraftversusleukemiaeffectinanacutelymphoblasticleukemiapatientwithcytogeneticrelapseafterallogeneicstemcelltransplantation |