Variant APOL1 protein in plasma associates with larger particles in humans and mouse models of kidney injury
<h4>Background</h4> Genetic variants in apolipoprotein L1 (APOL1), a protein that protects humans from infection with African trypanosomes, explain a substantial proportion of the excess risk of chronic kidney disease affecting individuals with sub-Saharan ancestry. The mechanisms by whi...
Main Authors: | Michael Andrews, Teruhiko Yoshida, Clark M. Henderson, Hannah Pflaum, Ayako McGregor, Joshua A. Lieberman, Ian H. de Boer, Tomas Vaisar, Jonathan Himmelfarb, Bryan Kestenbaum, Joon-Yong Chung, Stephen M. Hewitt, Briana A. Santo, Brandon Ginley, Pinaki Sarder, Avi Z. Rosenberg, Taichi Murakami, Jeffrey B. Kopp, Zsuzsanna Kuklenyik, Andrew N. Hoofnagle |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2022-01-01
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Series: | PLoS ONE |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9591058/?tool=EBI |
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