Diagnostic Value of 25-Hydroxyvitamin D Level and New Cytokines in Neonatal Sepsis
The aim of this study was to evaluate diagnostic value of 25-hydroxyvitamin D level, Upar, IL-33 and ST2 in comparison with C-reactive protein, TNF-α and Interleukin-6 in neonatal sepsis. A total of 106 term babies were included 20 of whom were the control group. We used only data of high probable s...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2014-05-01
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| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/1721727X1401200209 |
| _version_ | 1818554500529520640 |
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| author | F. Çekmez G. Aydemir S. Yildirim Ö. Bulut T. Tunç M. Kul E.Z. İnce A. Çoban |
| author_facet | F. Çekmez G. Aydemir S. Yildirim Ö. Bulut T. Tunç M. Kul E.Z. İnce A. Çoban |
| author_sort | F. Çekmez |
| collection | DOAJ |
| description | The aim of this study was to evaluate diagnostic value of 25-hydroxyvitamin D level, Upar, IL-33 and ST2 in comparison with C-reactive protein, TNF-α and Interleukin-6 in neonatal sepsis. A total of 106 term babies were included 20 of whom were the control group. We used only data of high probable sepsis with blood culture positive infants, therefore 46 infants were excluded. Blood was collected from infants from the first day of sepsis (1.value) and 48–72 hours later (2.value). There were significant differences between the controls and sepsis (1.value) for 25-hydroxyvitamin D levels (35±19ng/ml and 69±7.5ng/ml, p=0.01), for IL-33 levels (90±34 ng/ml and 412±170 ng/ml, p=0.01), for sST2 levels (453±44 ng/ml and 4120±2720ng/ml, p=0.01), for sUpar levels (2.1±1.3 ng/ml and 11.4 ± 5.2 ng/ml, p=0.01), respectively. There were significant differences between sepsis (1.value) and sepsis (2.value.) with reference to 25-hydroxyvitamin D, IL-33, sST2, and suPAR levels, respectively. In the light of these results, it may be suggested that 25-hydroxyvitamin D level, upar, IL-33 and ST2 can be used as an acute phase reactant like C-reactive protein, TNF-α and Interleukin-6 in diagnosis of neonatal sepsis. |
| first_indexed | 2024-12-12T09:40:29Z |
| format | Article |
| id | doaj.art-6d32fae276fa49a5840c38954a1292df |
| institution | Directory Open Access Journal |
| issn | 1721-727X |
| language | English |
| last_indexed | 2024-12-12T09:40:29Z |
| publishDate | 2014-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj.art-6d32fae276fa49a5840c38954a1292df2022-12-22T00:28:34ZengSAGE PublishingEuropean Journal of Inflammation1721-727X2014-05-011210.1177/1721727X1401200209Diagnostic Value of 25-Hydroxyvitamin D Level and New Cytokines in Neonatal SepsisF. Çekmez0G. Aydemir1S. Yildirim2Ö. Bulut3T. Tunç4M. Kul5E.Z. İnce6A. Çoban7 Department of Pediatrics, Division of Neonatology, GATA Medical Faculty, Istanbul, Turkey Department of Pediatrics, Division of Neonatology, GATA Medical Faculty, Istanbul, Turkey Department of Pediatrics, Division of Neonatology, Istanbul Medical Faculty, Turkey Department of Pediatrics, Division of Neonatology, Istanbul Medical Faculty, Turkey Department of Pediatrics, Division of Neonatology, GATA Medical Faculty, Ankara, Turkey Department of Pediatrics, Division of Neonatology, GATA Medical Faculty, Istanbul, Turkey Department of Pediatrics, Division of Neonatology, Istanbul Medical Faculty, Turkey Department of Pediatrics, Division of Neonatology, Istanbul Medical Faculty, TurkeyThe aim of this study was to evaluate diagnostic value of 25-hydroxyvitamin D level, Upar, IL-33 and ST2 in comparison with C-reactive protein, TNF-α and Interleukin-6 in neonatal sepsis. A total of 106 term babies were included 20 of whom were the control group. We used only data of high probable sepsis with blood culture positive infants, therefore 46 infants were excluded. Blood was collected from infants from the first day of sepsis (1.value) and 48–72 hours later (2.value). There were significant differences between the controls and sepsis (1.value) for 25-hydroxyvitamin D levels (35±19ng/ml and 69±7.5ng/ml, p=0.01), for IL-33 levels (90±34 ng/ml and 412±170 ng/ml, p=0.01), for sST2 levels (453±44 ng/ml and 4120±2720ng/ml, p=0.01), for sUpar levels (2.1±1.3 ng/ml and 11.4 ± 5.2 ng/ml, p=0.01), respectively. There were significant differences between sepsis (1.value) and sepsis (2.value.) with reference to 25-hydroxyvitamin D, IL-33, sST2, and suPAR levels, respectively. In the light of these results, it may be suggested that 25-hydroxyvitamin D level, upar, IL-33 and ST2 can be used as an acute phase reactant like C-reactive protein, TNF-α and Interleukin-6 in diagnosis of neonatal sepsis.https://doi.org/10.1177/1721727X1401200209 |
| spellingShingle | F. Çekmez G. Aydemir S. Yildirim Ö. Bulut T. Tunç M. Kul E.Z. İnce A. Çoban Diagnostic Value of 25-Hydroxyvitamin D Level and New Cytokines in Neonatal Sepsis European Journal of Inflammation |
| title | Diagnostic Value of 25-Hydroxyvitamin D Level and New Cytokines in Neonatal Sepsis |
| title_full | Diagnostic Value of 25-Hydroxyvitamin D Level and New Cytokines in Neonatal Sepsis |
| title_fullStr | Diagnostic Value of 25-Hydroxyvitamin D Level and New Cytokines in Neonatal Sepsis |
| title_full_unstemmed | Diagnostic Value of 25-Hydroxyvitamin D Level and New Cytokines in Neonatal Sepsis |
| title_short | Diagnostic Value of 25-Hydroxyvitamin D Level and New Cytokines in Neonatal Sepsis |
| title_sort | diagnostic value of 25 hydroxyvitamin d level and new cytokines in neonatal sepsis |
| url | https://doi.org/10.1177/1721727X1401200209 |
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