Shigella entry unveils a calcium/calpain-dependent mechanism for inhibiting sumoylation

Shigella entry unveils a calcium/calpain-dependent mechanism for inhibiting sumoylation

Disruption of the sumoylation/desumoylation equilibrium is associated with several disease states such as cancer and infections, however the mechanisms regulating the global SUMO balance remain poorly defined. Here, we show that infection by Shigella flexneri, the causative agent of human bacillary...

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Bibliographic Details
Main Authors: Pierre Lapaquette, Sabrina Fritah, Nouara Lhocine, Alexandra Andrieux, Giulia Nigro, Joëlle Mounier, Philippe Sansonetti, Anne Dejean
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-12-01
Series:eLife
Subjects:
shigella
sumoylation
calpain
Online Access:https://elifesciences.org/articles/27444

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