Comparative evaluation of biased agonists Sarcosine1, d‐Alanine8‐Angiotensin (Ang) II (SD Ang II) and Sarcosine1, Isoleucine8‐Ang II (SI Ang II) and their radioiodinated congeners binding to rat liver membrane AT1 receptors

Comparative evaluation of biased agonists Sarcosine1, d‐Alanine8‐Angiotensin (Ang) II (SD Ang II) and Sarcosine1, Isoleucine8‐Ang II (SI Ang II) and their radioiodinated congeners binding to rat liver membrane AT1 receptors

Abstract Angiotensin II analogue and β‐arrestin biased agonist TRV027 (Sarcosine1, d‐Alanine8‐Angiotensin (Ang) II; SD Ang II), developed by Trevena, Inc. in the early 2010s, brought hopes of a novel treatment for cardiovascular diseases, due to its ability to simultaneously cause signaling through...

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Bibliographic Details
Main Authors: Natalia M. Noto, Yazmin M. Restrepo, Hong W. Pang, Filipe Stoyell‐Conti, Crystal A. West, Robert C. Speth
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Pharmacology Research & Perspectives
Subjects:
AT1R
binding assay
GPCR
d‐Alanine8‐Angiotensin II
Sarcosine1, Isoleucine8‐Angiotensin II
TRV027
Online Access:https://doi.org/10.1002/prp2.1053

Internet

https://doi.org/10.1002/prp2.1053

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