Oxidative Balance Scores (OBSs) Integrating Nutrient, Food and Lifestyle Dimensions: Development of the NutrientL-OBS and FoodL-OBS
Oxidative Balance Scores (OBS) are tools that allow us to assess the individual’s antioxidant state by ranking both antioxidant and pro-oxidant components of dietary and lifestyle factors. Our aim was to develop novel OBSs accounting for either the global supply of nutrient antioxidants in the diet,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/2/300 |
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| author | Ángela Hernández-Ruiz Belén García-Villanova Eduardo J. Guerra-Hernández Cayetano Javier Carrión-García Pilar Amiano María-José Sánchez Esther Molina-Montes |
| author_facet | Ángela Hernández-Ruiz Belén García-Villanova Eduardo J. Guerra-Hernández Cayetano Javier Carrión-García Pilar Amiano María-José Sánchez Esther Molina-Montes |
| author_sort | Ángela Hernández-Ruiz |
| collection | DOAJ |
| description | Oxidative Balance Scores (OBS) are tools that allow us to assess the individual’s antioxidant state by ranking both antioxidant and pro-oxidant components of dietary and lifestyle factors. Our aim was to develop novel OBSs accounting for either the global supply of nutrient antioxidants in the diet, or the intake of antioxidant-rich foods, in combination with lifestyle factors. Pro-oxidant factors were also considered. Within two centers of the Spanish European Prospective Investigation into Cancer and Nutrition (EPIC) study, EPIC-Granada and EPIC-Gipuzkoa (N = 14,756 participants), we developed the Nurient, Food and Lifestyle OBS (NutrientL-OBS and FoodL-OBS), and their simplified versions (solely with dietary or lifestyle factors, the Nutrient-OBS, Food-OBS and L-OBS). Their antioxidant potential was evaluated considering their relationship with: (i) 20 scores of adherence to the Mediterranean Diet (MD); and, (ii) 25 biomarkers of antioxidant nutrients (ascorbic acid, β-carotene, etc.), inflammation (CRP, TNF-alpha, etc.) and oxidative stress (uric acid), among 210 participants. Spearman correlation and multivariate linear regression analyses were applied to analyze these associations. Some statistically significant relationships were encountered between the NutrientL-OBS and the FoodL-OBS with the MD scores, and with ascorbic acid (per one-unit increase in OBS: β = 0.012 and 0.015; <i>p</i> = 0.022 and 0.008, respectively) and CRP (per one-unit increase in both OBS: β = −0.02; <i>p</i> = 0.02); the latter appeared to be restricted to the OBS´s lifestyle components. In conclusion, the NutrientL- and FoodL-OBSs and their sub-versions are related to antioxidant-rich dietary patterns and to biomarkers of antioxidant nutrient intake and inflammation, supporting that these tools are valid to assess the individual´s oxidative/antioxidant status. |
| first_indexed | 2024-03-09T22:44:33Z |
| format | Article |
| id | doaj.art-6d3412cd2bcd44f48e03a661fc33e93a |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T22:44:33Z |
| publishDate | 2022-01-01 |
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| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-6d3412cd2bcd44f48e03a661fc33e93a2023-11-23T18:31:36ZengMDPI AGAntioxidants2076-39212022-01-0111230010.3390/antiox11020300Oxidative Balance Scores (OBSs) Integrating Nutrient, Food and Lifestyle Dimensions: Development of the NutrientL-OBS and FoodL-OBSÁngela Hernández-Ruiz0Belén García-Villanova1Eduardo J. Guerra-Hernández2Cayetano Javier Carrión-García3Pilar Amiano4María-José Sánchez5Esther Molina-Montes6Department of Nutrition and Food Science, Faculty of Pharmacy, Campus Universitario de Cartuja S/N, University of Granada, 18071 Granada, SpainDepartment of Nutrition and Food Science, Faculty of Pharmacy, Campus Universitario de Cartuja S/N, University of Granada, 18071 Granada, SpainDepartment of Nutrition and Food Science, Faculty of Pharmacy, Campus Universitario de Cartuja S/N, University of Granada, 18071 Granada, SpainDepartment of Nutrition and Food Science, Faculty of Pharmacy, Campus Universitario de Cartuja S/N, University of Granada, 18071 Granada, SpainMinistry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, 20014 San Sebastian, SpainCIBER of Epidemiology and Public Health (CIBERESP), 28029 Madrid, SpainDepartment of Nutrition and Food Science, Faculty of Pharmacy, Campus Universitario de Cartuja S/N, University of Granada, 18071 Granada, SpainOxidative Balance Scores (OBS) are tools that allow us to assess the individual’s antioxidant state by ranking both antioxidant and pro-oxidant components of dietary and lifestyle factors. Our aim was to develop novel OBSs accounting for either the global supply of nutrient antioxidants in the diet, or the intake of antioxidant-rich foods, in combination with lifestyle factors. Pro-oxidant factors were also considered. Within two centers of the Spanish European Prospective Investigation into Cancer and Nutrition (EPIC) study, EPIC-Granada and EPIC-Gipuzkoa (N = 14,756 participants), we developed the Nurient, Food and Lifestyle OBS (NutrientL-OBS and FoodL-OBS), and their simplified versions (solely with dietary or lifestyle factors, the Nutrient-OBS, Food-OBS and L-OBS). Their antioxidant potential was evaluated considering their relationship with: (i) 20 scores of adherence to the Mediterranean Diet (MD); and, (ii) 25 biomarkers of antioxidant nutrients (ascorbic acid, β-carotene, etc.), inflammation (CRP, TNF-alpha, etc.) and oxidative stress (uric acid), among 210 participants. Spearman correlation and multivariate linear regression analyses were applied to analyze these associations. Some statistically significant relationships were encountered between the NutrientL-OBS and the FoodL-OBS with the MD scores, and with ascorbic acid (per one-unit increase in OBS: β = 0.012 and 0.015; <i>p</i> = 0.022 and 0.008, respectively) and CRP (per one-unit increase in both OBS: β = −0.02; <i>p</i> = 0.02); the latter appeared to be restricted to the OBS´s lifestyle components. In conclusion, the NutrientL- and FoodL-OBSs and their sub-versions are related to antioxidant-rich dietary patterns and to biomarkers of antioxidant nutrient intake and inflammation, supporting that these tools are valid to assess the individual´s oxidative/antioxidant status.https://www.mdpi.com/2076-3921/11/2/300antioxidantoxidative stressMediterranean dietbiomarkerdiet quality |
| spellingShingle | Ángela Hernández-Ruiz Belén García-Villanova Eduardo J. Guerra-Hernández Cayetano Javier Carrión-García Pilar Amiano María-José Sánchez Esther Molina-Montes Oxidative Balance Scores (OBSs) Integrating Nutrient, Food and Lifestyle Dimensions: Development of the NutrientL-OBS and FoodL-OBS Antioxidants antioxidant oxidative stress Mediterranean diet biomarker diet quality |
| title | Oxidative Balance Scores (OBSs) Integrating Nutrient, Food and Lifestyle Dimensions: Development of the NutrientL-OBS and FoodL-OBS |
| title_full | Oxidative Balance Scores (OBSs) Integrating Nutrient, Food and Lifestyle Dimensions: Development of the NutrientL-OBS and FoodL-OBS |
| title_fullStr | Oxidative Balance Scores (OBSs) Integrating Nutrient, Food and Lifestyle Dimensions: Development of the NutrientL-OBS and FoodL-OBS |
| title_full_unstemmed | Oxidative Balance Scores (OBSs) Integrating Nutrient, Food and Lifestyle Dimensions: Development of the NutrientL-OBS and FoodL-OBS |
| title_short | Oxidative Balance Scores (OBSs) Integrating Nutrient, Food and Lifestyle Dimensions: Development of the NutrientL-OBS and FoodL-OBS |
| title_sort | oxidative balance scores obss integrating nutrient food and lifestyle dimensions development of the nutrientl obs and foodl obs |
| topic | antioxidant oxidative stress Mediterranean diet biomarker diet quality |
| url | https://www.mdpi.com/2076-3921/11/2/300 |
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