Mechanistic insights into molecular evolution of species-specific differential glycosaminoglycan binding surfaces in growth-related oncogene chemokines

Mechanistic insights into molecular evolution of species-specific differential glycosaminoglycan binding surfaces in growth-related oncogene chemokines

Chemokines are chemotactic cytokines involved in leucocyte trafficking to infected tissue. Growth-related oncogene (GRO) chemokines namely CXCL1, CXCL2 and CXCL3 are neutrophil activating chemokines sharing a conserved three-dimensional structure, but encompassing functional diversity due to gene du...

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Bibliographic Details
Main Authors: Khushboo Gulati, Minal Jamsandekar, Krishna Mohan Poluri
Format: Article
Language:English
Published: The Royal Society 2017-01-01
Series:Royal Society Open Science
Subjects:
molecular evolution
chemokines
glycosaminoglycans
neutrophil trafficking
growth-related oncogenes
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.171059

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https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.171059

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