Chemokines in patients with Alzheimer's disease: A meta-analysis
BackgroundAlzheimer's disease (AD) is the most common neurodegenerative disease in elderly people. Many researches have reported that neuroinflammation is related to AD. Chemokines are a class of small cytokines that play important roles in cell migration and cell communication, which involved...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1047810/full |
| _version_ | 1811157816533057536 |
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| author | Hecheng Wang Yu Zong Lei Zhu Weiyi Wang Yanshuo Han |
| author_facet | Hecheng Wang Yu Zong Lei Zhu Weiyi Wang Yanshuo Han |
| author_sort | Hecheng Wang |
| collection | DOAJ |
| description | BackgroundAlzheimer's disease (AD) is the most common neurodegenerative disease in elderly people. Many researches have reported that neuroinflammation is related to AD. Chemokines are a class of small cytokines that play important roles in cell migration and cell communication, which involved in neuroinflammation. Up to now there is no meta-analysis to explore the difference of chemokines between AD patients and healthy elderly individuals.MethodWe searched PubMed, Web of science, Cochrane library, EMBASE and Scopus databases from inception to January 2022. Data were extracted by two independent reviewers, and the Review Manager 5.3 was used for the meta-analysis.ResultThirty-two articles were included and analyzed. The total number of participants in the included study was 3,331. We found that the levels of CCL5 (SMD = 2.56, 95% CI: 1.91–3.21), CCL15 (SMD = 3.30, 95% CI: 1.48–5.13) and IP-10 (SMD = 3.88, 95% CI: 1.84–5.91) in the plasma of AD patients were higher than healthy people. MCP-1 protein (SMD = 0.67, 95% CI: 0.29–1.05) in the AD patients' CSF was higher than healthy controls.ConclusionThese results suggested that chemokines may play an important role in AD. These findings could provide evidences for the diagnosis and treatment of AD.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021278736, identifier: CRD42021278736. |
| first_indexed | 2024-04-10T05:13:48Z |
| format | Article |
| id | doaj.art-6d35d636497d4097959ec3cd1f894e94 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-10T05:13:48Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-6d35d636497d4097959ec3cd1f894e942023-03-09T05:20:39ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-03-011510.3389/fnagi.2023.10478101047810Chemokines in patients with Alzheimer's disease: A meta-analysisHecheng Wang0Yu Zong1Lei Zhu2Weiyi Wang3Yanshuo Han4School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, ChinaSchool of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, ChinaSchool of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, ChinaDepartment of Cardiovascular Diseases, Civil Aviation General Hospital, Peking University, Beijing, ChinaSchool of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, ChinaBackgroundAlzheimer's disease (AD) is the most common neurodegenerative disease in elderly people. Many researches have reported that neuroinflammation is related to AD. Chemokines are a class of small cytokines that play important roles in cell migration and cell communication, which involved in neuroinflammation. Up to now there is no meta-analysis to explore the difference of chemokines between AD patients and healthy elderly individuals.MethodWe searched PubMed, Web of science, Cochrane library, EMBASE and Scopus databases from inception to January 2022. Data were extracted by two independent reviewers, and the Review Manager 5.3 was used for the meta-analysis.ResultThirty-two articles were included and analyzed. The total number of participants in the included study was 3,331. We found that the levels of CCL5 (SMD = 2.56, 95% CI: 1.91–3.21), CCL15 (SMD = 3.30, 95% CI: 1.48–5.13) and IP-10 (SMD = 3.88, 95% CI: 1.84–5.91) in the plasma of AD patients were higher than healthy people. MCP-1 protein (SMD = 0.67, 95% CI: 0.29–1.05) in the AD patients' CSF was higher than healthy controls.ConclusionThese results suggested that chemokines may play an important role in AD. These findings could provide evidences for the diagnosis and treatment of AD.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021278736, identifier: CRD42021278736.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1047810/fullAlzheimer's diseasechemokinesmeta-analysisplasmaCSF |
| spellingShingle | Hecheng Wang Yu Zong Lei Zhu Weiyi Wang Yanshuo Han Chemokines in patients with Alzheimer's disease: A meta-analysis Frontiers in Aging Neuroscience Alzheimer's disease chemokines meta-analysis plasma CSF |
| title | Chemokines in patients with Alzheimer's disease: A meta-analysis |
| title_full | Chemokines in patients with Alzheimer's disease: A meta-analysis |
| title_fullStr | Chemokines in patients with Alzheimer's disease: A meta-analysis |
| title_full_unstemmed | Chemokines in patients with Alzheimer's disease: A meta-analysis |
| title_short | Chemokines in patients with Alzheimer's disease: A meta-analysis |
| title_sort | chemokines in patients with alzheimer s disease a meta analysis |
| topic | Alzheimer's disease chemokines meta-analysis plasma CSF |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1047810/full |
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